Abstract:
BACKGROUND:Through differentiation processes, keratinocytes provide a physical barrier to our bodies and control skin features such as moisturization, wrinkles and pigmentation. Keratinocyte differentiation is disturbed in several skin diseases such as psoriasis and atopic dermatitis. OBJECTIVE:The aim of this study is to evaluate the keratinocyte differentiation-enhancing effect of rose absolute oil (RAO). METHODS:Primary cultured human normal keratinocytes were treated with RAO, and differentiation then checked by the expression of marker genes. RESULTS:RAO did not induce cytotoxicity on cultured keratinocytes at a dose of 10microM. The level of involucrin, an early marker for keratinocyte differentiation, was significantly increased by RAO. Concomitantly, RAO increased involucrin promoter activity, indicating that RAO increased involucrin gene expression at the mRNA level. Furthermore, RAO increased the level of filaggrin in cultured keratinocytes, and in the granular layer of mouse skin. In line with these results, RAO decreased the proliferation of keratinocytes cultured in vitro. When RAO was applied topically on the tape-stripped mouse skins, it accelerated the recovery of disturbed barrier function. CONCLUSION:These results suggest that RAO may be applicable for the control of skin texture and keratinocyte differentiation-related skin diseases.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Kim JH,Choi DK,Lee SS,Choi SJ,Kim CD,Yoon TJ,Lee JHdoi
10.5021/ad.2010.22.3.255subject
Has Abstractpub_date
2010-08-01 00:00:00pages
255-61issue
3eissn
1013-9087issn
2005-3894journal_volume
22pub_type
杂志文章abstract:BACKGROUND:The treatment of post-inflammatory hyperpigmentation (PIH) remains challenging. Tranexamic acid, a well-known anti-fibrinolytic drug, has recently demonstrated a curative effect towards melasma and ultraviolet-induced PIH in Asian countries. However, the precise mechanism of its inhibitory effect on melanoge...
journal_title:Annals of dermatology
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abstract:BACKGROUND:Patients with atopic dermatitis (AD) should be relatively well informed about the disorder to control their condition and prevent flare-ups. Thus far, there is no accurate information about the disease awareness levels and therapeutic behavior of AD patients. OBJECTIVE:To collect data on patients' knowledge...
journal_title:Annals of dermatology
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abstract::Non-tubecrulosis mycobacterium infections were increasingly reported either pulmonary or extrapulmonary in the past decades. In Taiwan, we noticed several reports about the soft tissue infections caused by rapid growing mycobacterium such as Mycobacterium abscessus, Mycobacterium chelonae, on newspaper, magazines, or ...
journal_title:Annals of dermatology
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abstract:BACKGROUND:Topical steroid treatment induces diverse local Wand systemic adverse effects. Several approaches have been tried to reduce the steroid-induced adverse effects. Simultaneous application of physiological lipid mixture is also suggested. OBJECTIVE:Novel vehicles for topical glucocorticoids formulation were ev...
journal_title:Annals of dermatology
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abstract:BACKGROUND:Gray hair naturally develops in the process of human aging. Many people with gray hair periodically dye their hair. Hair dyeing products are widely used and they can cause adverse effects. Therefore, the user's knowledge and recognition about hair dyeing and related side effects are important. OBJECTIVE:The...
journal_title:Annals of dermatology
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abstract::Hematodermic neoplasm (HN) is a clinically aggressive neoplasm with a high incidence of cutaneous involvement and a risk of leukemic dissemination. In the recent WHO-EORTC classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ HN because of its derivation from a plasmacytoid de...
journal_title:Annals of dermatology
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abstract::Lichen aureus is a rare type of chronic pigmented purpuric dermatosis. The eruptions consist of discrete or confluent golden to brownish lichenoid macules and papules, and are usually asymptomatic. Lichen aureus commonly occurs in young adults, but less frequently in children. We report the first case of multiple lich...
journal_title:Annals of dermatology
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
pub_type: 杂志文章
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journal_title:Annals of dermatology
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doi:10.5021/ad.2010.22.4.456
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abstract:Background:Prevalence of subungual melanoma (SUM) in Asian population is relatively high and early clinical detection improves both quality of life and survival. Objective:We sought to establish screening strategy for SUM in situ. Methods:We retrospectively reviewed medical records of 8 patients pathologically diagno...
journal_title:Annals of dermatology
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journal_title:Annals of dermatology
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doi:10.5021/ad.2011.23.2.239
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journal_title:Annals of dermatology
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doi:10.5021/ad.2013.25.4.493
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journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.3.381
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journal_title:Annals of dermatology
pub_type: 杂志文章
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journal_title:Annals of dermatology
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doi:10.5021/ad.2011.23.S3.S329
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journal_title:Annals of dermatology
pub_type: 杂志文章
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
pub_type: 杂志文章
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
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journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S2.S160
更新日期:2011-10-01 00:00:00
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journal_title:Annals of dermatology
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更新日期:2012-11-01 00:00:00
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journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.3.358
更新日期:2010-08-01 00:00:00
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journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.4.267
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