Abstract：
BACKGROUND:Computer-aided image analysis (CAIA) has been suggested as an effective diagnostic tool for pigmented skin lesions (PSLs), especially melanoma. However, few studies on benign PSLs have been reported. OBJECTIVE:The purpose of this study was to evaluate benign PSLs with our CAIA software and analyze the differences between the parameters of those lesions. METHODS:By using homegrown CAIA software, we analyzed 3 kinds of PSLs-nevus, lentigo, and seborrheic keratosis. The group of seborrheic keratosis was divided into pigmented seborrheic keratosis, sebolentigine, and hyperkeratotic seborrheic keratosis. The CAIA was used to extract the color, as well as the morphological, textural, and topological features from each image. RESULTS:In line with clinical observations, the objective parameters indicated that nevus was dark and round, lentigo was small and bright, and seborrheic keratosis was large and spiky. The surface of nevus showed the highest contrast and correlation. In topological analysis, the concentricity clearly separated melanocytic lesions from seborrheic keratosis. The parameters of pigmented seborrheic keratosis were between those of typical nevus and seborrheic keratosis. CONCLUSION:We confirmed that definite correlations exist between the subjective differentiation by experts' examination and the objective evaluation by using CAIA. We also found that the morphological differences observed in CAIA were greatly influenced by the composition ratios of keratinocytes and melanocytes, which are already known histopathological characteristics of each PSL.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Choi JW,Ryu HH,Byun SY,Youn SWdoi
10.5021/ad.2014.26.3.314subject
Has Abstractpub_date
2014-06-01 00:00:00pages
314-20issue
3eissn
1013-9087issn
2005-3894journal_volume
26pub_type
杂志文章abstract：BACKGROUND:A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). OBJECTIVE:It w...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2016.28.4.470
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:The use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. While the role of growth factors in wound healing is well established, their use in skin rejuvenation has only recently been to be studied and no controlled trials have been performed. OBJECTIVE:We evaluated the anti...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2014.26.5.584
更新日期：2014-10-01 00:00:00
abstract：:[This corrects the article on p. 211 in vol. 30, PMID: 29606819.]. ...
journal_title：Annals of dermatology
pub_type： 已发布勘误
doi：10.5021/ad.2018.30.4.511
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-γ) are released from various inflammatory and resident cells, and have been implicated in the init...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2015.27.2.128
更新日期：2015-04-01 00:00:00
abstract：:Multiple autoimmune syndrome (MAS) is a rare condition, in which at least three well-defined autoimmune diseases co-occur in a single patient. Although the pathogenesis of MAS remains poorly understood, genetic, immunological, hormonal, and environmental factors may all play a role. Although three classic subtypes of ...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2017.29.6.782
更新日期：2017-12-01 00:00:00
abstract：:Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2012.24.2.115
更新日期：2012-05-01 00:00:00
abstract：:Intravascular lymphoma (IVL) is a rare disorder characterized by the presence of large neoplastic lymphoid cells restricted to the lumens of small vessels with a predilection for the skin and the central nervous system. While the vast majority of cases involving IVL are of B-cell lineage, the disease rarely affects th...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2014.26.4.496
更新日期：2014-08-01 00:00:00
abstract：:This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discont...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.S3.S404
更新日期：2011-12-01 00:00:00
abstract：:Sweet's syndrome is a reactive dermatosis characterized clinically by fever, leukocytosis, and multiple, erythematous, painful plaques. Histopathologic examination reveals a band-like dense dermal inflammatory infiltrate composed mainly of neutrophils with papillary dermal edema, and no features of vasculitis. We repo...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2009.21.3.300
更新日期：2009-08-01 00:00:00
abstract：:Pityriasis versicolor is a superficial infection of the stratum corneum, which is caused by the Malassezia species. Tge Malassezia species consist of 12 subspecies, including M. furfur, M. pachydermatis, M. symphodialis and M. globasa. The Malassezia species are classified as a normal flora, particularly in the sebum ...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2012.24.3.345
更新日期：2012-08-01 00:00:00
abstract：:Sarcoidosis is a systemic inflammatory disease of an unknown origin and it is characterized by the presence of noncaseating epitheloid cell granulomas in multiple organs. Herein we report on a case of cutaneous and pulmonary sarcoidosis that was associated with interferon alpha treatment for hepatitis C. A 39-year-old...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.2.239
更新日期：2011-05-01 00:00:00
abstract：:Fexofenadine (Allegra® 180) is a second-generation antihistamine. It is widely used as anti-allergic drug, which suppresses various allergic reactions mediated by histamines. A few cases of H1-antihistamine-induced urticaria have been reported. Herein, we report a rare case of fexofenadine-induced urticaria which was ...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.S3.S329
更新日期：2011-12-01 00:00:00
abstract：:Membranous lipodystrophy is characterized by the presence of microcysts lined by amorphous, eosinophilic material with an arabesque appearance. We experienced a case of a 72-year-old man who had dark brownish, pruritic papules on the arms, legs, and back. Histopathologic examination of a biopsied lesion showed homogen...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2009.21.2.174
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Angiogenesis is crucial for wound healing and exogenous supplements of the angiogenic growth factors have been known to promote cutaneous wound healing. Angiopoietin (Ang) 1 is a recently discovered angiogenic factor and there have been few studies of its effect on cutaneous wound healing. OBJECTIVE:We exam...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2008.20.2.49
更新日期：2008-06-01 00:00:00
abstract：:Eccrine porocarcinoma is a rare neoplasm that originates from the intraepidermal ductal portion of the eccrine sweat gland, and it usually occurs on the pre-existing lesion of benign eccine poroma. Its occurrence is more common in females and elderly persons. We present a case of a 44-year-old man who suffered from ec...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.S1.S79
更新日期：2011-09-01 00:00:00
abstract：:Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.2.201
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE:The aim of this study was to determine the c-Met expression pattern and the protein expression level in sele...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2011.23.1.33
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Several workers have found that Malassezia are capable of suppressing cytokine release and downregulating the phagocytic function of monocytes. But lipid-depleted Malassezia furfur (M. furfur) extracts have also been shown to induce increased production of TNF-alpha, IL-6 and IL-1beta in monocytes. We though...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2009.21.2.130
更新日期：2009-05-01 00:00:00
abstract：:We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and this was accompanied with fever. A serologic test was positive for IgM varicella zoster antibody and coxsackievirus A16 antibody. The histopathologic examination from the palm reve...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2009.21.1.98
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Urticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life. OBJECTIVE:The objective of this study is to characteriz...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2017.29.2.143
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. OBJECTIVE:The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, die...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2013.25.1.23
更新日期：2013-02-01 00:00:00
abstract：:Telogen effluvium is categorized in nonscarring alopecia, which shows scalp hair thinning and shedding diffusely resulting from inducing factors such as physiological stressful events and several acute or chronic diseases. It usually appears in female patients following parturition, as well as after febrile disease, m...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2018.30.2.214
更新日期：2018-04-01 00:00:00
abstract：:Bowenoid papulosis (BP) is a disease that mainly occurs in sexually active young adults. The patients present with multiple pigmented papular lesions with a verrucous surface on the anogenital area. Although extragenital BP is usually associated with concomitant genital involvement, a few cases of isolated extragenita...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2014.26.3.381
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:β-catenin plays a pivotal role in hair follicle development and hair growth cycle. OBJECTIVE:The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. METHODS:Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-term...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2011.23.2.138
更新日期：2011-05-01 00:00:00
abstract：:Lymphomatoid keratosis (LK) is considered to be a rare variant of cutaneous lymphoid hyperplasia, with epidermotropism. We herein report a case of LK which developed on the abdomen of an elderly Korean woman. A 60-year-old woman presented with a 10-year history of a pruritic, solitary, brown to black plaque on the abd...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2010.22.2.219
更新日期：2010-05-01 00:00:00
abstract：:Lichen aureus is a rare type of chronic pigmented purpuric dermatosis. The eruptions consist of discrete or confluent golden to brownish lichenoid macules and papules, and are usually asymptomatic. Lichen aureus commonly occurs in young adults, but less frequently in children. We report the first case of multiple lich...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2009.21.4.393
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce. OBJECTIVE:In the present in vitro study, we compared the effect of culture media supplemente...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2015.27.6.709
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Through differentiation processes, keratinocytes provide a physical barrier to our bodies and control skin features such as moisturization, wrinkles and pigmentation. Keratinocyte differentiation is disturbed in several skin diseases such as psoriasis and atopic dermatitis. OBJECTIVE:The aim of this study i...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2010.22.3.255
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the development and progression of malignant cutaneous tumors. OBJECTIVE:The aim of this study was to de...
journal_title：Annals of dermatology
pub_type： 杂志文章
doi：10.5021/ad.2010.22.4.412
更新日期：2010-11-01 00:00:00
abstract：:Blastomycosis-like pyoderma is a rare, vegetating skin lesion that is an unusual exaggerated tissue reaction possibly to prolonged primary or secondary bacterial infection. We report a case of blastomycosis-like pyoderma in a man with Down syndrome, diabetes mellitus and hypothyroidism who responsed poorly to conventi...
journal_title：Annals of dermatology
pub_type：
doi：10.5021/ad.2011.23.3.365
更新日期：2011-08-01 00:00:00
