当前位置： SCI文献检索 > Annals of Dermatology期刊下所有文献 > The Effect of Detergents on the Morphology and Immunomodulatory Activity of Malassezia furfur.

The Effect of Detergents on the Morphology and Immunomodulatory Activity of Malassezia furfur.

Abstract：

BACKGROUND:Several workers have found that Malassezia are capable of suppressing cytokine release and downregulating the phagocytic function of monocytes. But lipid-depleted Malassezia furfur (M. furfur) extracts have also been shown to induce increased production of TNF-alpha, IL-6 and IL-1beta in monocytes. We thought that the detergents in shampoos or soaps could change the composition of the lipid in the M. furfur cell wall. OBJECTIVE:We studied whether detergents affect the morphology of M. furfur and if the inflammatory cytokine profiles change in the monocytes treated with detergent-treated M. furfur. METHODS:Commonly used detergents such as sodium lauryl sulfate, ammonium lauryl sulfate and tween-80 were respectively added to the modified Leeming-Notman's media. M. furfur was cultivated in each media (detergent-added or untreated). Thereafter, the surface morphology of the yeast was evaluated by scanning and transmission electron microscopy. The cytokine profiles of monocytes, which were treated by M. furfur with or without detergents, were also evaluated. RESULTS:The detergent-treated M. furfur were similar to the lipid-extracted form of M. furfur on the electron microscopic study, with a recessed, withered surface and with thinner and rather electron transparent cell walls than the detergent-untreated M. furfur. The levels of TNF-alpha were higher in monocytes treated with detergent-treated Malassezia than that in the monocytes treated with the detergent-untreated Malassezia (p<0.05). CONCLUSION:According to the findings in this study, it could be inferred that the detergents in shampoos or soaps affect the lipid layers of the Malassezia cell wall and these lipid-extracted Malassezia induce or aggravate some inflammatory conditions. But to correlate the relationship between detergents and Malassezia-associated diseases, in vivo experiments that will focus on short-term contact with detergents in real life conditions should be done.

journal_name

Ann Dermatol

journal_title

Annals of dermatology

authors

Kim SH,Ko HC,Kim MB,Kwon KS,Oh CK

doi

10.5021/ad.2009.21.2.130

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

130-5

issue

eissn

1013-9087

issn

2005-3894

journal_volume

pub_type

杂志文章

在线工具

The Effect of Detergents on the Morphology and Immunomodulatory Activity of Malassezia furfur.