Abstract:
BACKGROUND:There is evidence that glycosaminoglycans (GAGs) are present in the hair shaft within the follicle but there are no studies regarding GAGs isolation and measurement in the human hair shaft over the scalp surface, it means, in the free hair shaft. OBJECTIVE:The purpose of our research was to isolate and measure the total GAGs from human free hair shaft. METHODS:Seventy-five healthy individuals participated in the study, 58 adults, men and women over the age of 50 and 17 children (aged 4~9). GAGs in hair samples, received from the parietal and the occipital areas, were isolated with 4 M guanidine HCl and measured by the uronic acid-carbazole reaction assay. RESULTS:GAGs concentration was significantly higher in the occipital area than in the parietal area, in all study groups. GAG levels from both areas were significantly higher in children than in adults. GAG levels were not associated with gender, hair color or type. CONCLUSION:We report the presence of GAGs in the human free hair shaft and the correlation of hair GAG levels with the scalp area and participants' age.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Maniatopoulou E,Bonovas S,Sitaras Ndoi
10.5021/ad.2016.28.5.533subject
Has Abstractpub_date
2016-10-01 00:00:00pages
533-539issue
5eissn
1013-9087issn
2005-3894journal_volume
28pub_type
杂志文章abstract::[This corrects the article on p. 211 in vol. 30, PMID: 29606819.]. ...
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