Abstract:
BACKGROUND:Although intralesional methotrexate (MTX) is an effective, nonsurgical treatment of keratoacanthoma (KA), there have not been many reports of on the MTX treatment for KA in Korea. OBJECTIVE:The purpose of this study was to evaluate the clinical efficacy of the intralesional MTX for the treatment of KA in Korean patients. METHODS:We retrospectively studied seven patients with KA who received intralesional injection of MTX in our department. The efficacy was evaluated based on the physician assessment. Our review also included the cases of KA treated with intralesional MTX in Korean patients from the previous reports. We then analyzed the therapeutic regimens in the Korean patients by comparing them with the Caucasian patients. RESULTS:We identified 11 cases of Korean KA patients treated with an intralesional MTX, including seven from our institution and four from the Korean literature. Ten of the 11 patients (91%) showed a complete resolution with an intralesional MTX. No adverse events were observed during the treatment and the follow-up periods. No recurrence was found during the follow-up. In therapeutic analysis, the Korean patients required 2 to 7 injections (mean 4.6 injections) to achieve a tumor resolution with the mean time to clearing at 7.6 weeks. CONCLUSION:Intralesional MTX can be an effective and safe non-operative treatment modality for most Koreans with KA.
journal_name
Ann Dermatoljournal_title
Annals of dermatologyauthors
Yoo MG,Kim IHdoi
10.5021/ad.2014.26.2.172subject
Has Abstractpub_date
2014-04-01 00:00:00pages
172-6issue
2eissn
1013-9087issn
2005-3894journal_volume
26pub_type
杂志文章abstract::Touraine-Soulente-Golé Syndrome (TSG) or pachydermoperiostosis is a rare disorder characterized by pachydermia, periostosis & digital clubbing. Herein, we report a case of a 27 year old male, with the looks of a 47 year old. He presented with excessive wrinkling on his face since past 8 years. TSG syndrome was suspect...
journal_title:Annals of dermatology
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doi:10.5021/ad.2013.25.3.352
更新日期:2013-08-01 00:00:00
abstract::Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walki...
journal_title:Annals of dermatology
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doi:10.5021/ad.2011.23.S2.S239
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abstract:BACKGROUND:The use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. While the role of growth factors in wound healing is well established, their use in skin rejuvenation has only recently been to be studied and no controlled trials have been performed. OBJECTIVE:We evaluated the anti...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2014.26.5.584
更新日期:2014-10-01 00:00:00
abstract::Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, ...
journal_title:Annals of dermatology
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doi:10.5021/ad.2015.27.3.315
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the development and progression of malignant cutaneous tumors. OBJECTIVE:The aim of this study was to de...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2010.22.4.412
更新日期:2010-11-01 00:00:00
abstract::Pityriasis alba (PA) is a common benign disease, characterized by hypopigmented macules or patches on the face, usually seen in children. However, two uncommon variants exist, a pigmenting type and an extensive type. Extensive PA is rare. The lesions tend to be less scaly, more persistent, more generalized, more symme...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.3.146
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Through differentiation processes, keratinocytes provide a physical barrier to our bodies and control skin features such as moisturization, wrinkles and pigmentation. Keratinocyte differentiation is disturbed in several skin diseases such as psoriasis and atopic dermatitis. OBJECTIVE:The aim of this study i...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2010.22.3.255
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Short stature is sometimes seen in children with atopic dermatitis (AD); however, the topic has never been studied systematically. OBJECTIVE:The aim of this study was to show whether AD itself affects stature in children and to evaluate the influence of other relevant factors such as genetic background, die...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2013.25.1.23
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The expression of c-Met is substantially elevated in most malignant human cancers. We therefore searched for c-Met expression and compared the expression level among malignant skin cancers. OBJECTIVE:The aim of this study was to determine the c-Met expression pattern and the protein expression level in sele...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2011.23.1.33
更新日期:2011-02-01 00:00:00
abstract::Disseminated superficial porokeratosis (DSP) is a rare variant of porokeratosis, which is characterized histologically by cornoid lamella and clinically by central atrophy with elevated borders. DSP is usually associated with immunosuppressive states and hematopoietic malignancies, but rarely with malignancies of visc...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2008.20.4.193
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Malassezia yeasts are normal flora of the skin that are discovered in 75~98% of health subjects, but since its association with various skin disorders have been known, many studies have been conducted in the distribution of the yeasts. OBJECTIVE:To isolate, identify, and classify Malassezia yeasts from the ...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2009.21.1.18
更新日期:2009-02-01 00:00:00
abstract:Background:Alopecia areata (AA) affects anagen hair follicles resulting in non-scarring hair loss. Since its introduction, superficial cryotherapy has been used as one of the meaningful treatment modalities for AA. Objective:The purpose of this study is to clarify the therapeutic efficacy and safety of superficial cry...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2017.29.6.722
更新日期:2017-12-01 00:00:00
abstract::[This corrects the article on p. 211 in vol. 30, PMID: 29606819.]. ...
journal_title:Annals of dermatology
pub_type: 已发布勘误
doi:10.5021/ad.2018.30.4.511
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Severity grading is important for the assessment of psoriasis treatment efficacy. This is most commonly achieved by using the psoriasis area and severity index (PASI), a subjective tool with inherent inter-rater and intra-rater variability. PASI-naive dermatologists require training to properly conduct a PAS...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2015.27.5.557
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic derm...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2012.24.2.189
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:β-catenin plays a pivotal role in hair follicle development and hair growth cycle. OBJECTIVE:The aim of this study was to identify β-catenin-regulated genes in cultured human hair outer root sheath (ORS) cells. METHODS:Primary cultured ORS cells were transduced with recombinant adenovirus expressing N-term...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2011.23.2.138
更新日期:2011-05-01 00:00:00
abstract::The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.1.74
更新日期:2017-02-01 00:00:00
abstract::Hematodermic neoplasm (HN) is a clinically aggressive neoplasm with a high incidence of cutaneous involvement and a risk of leukemic dissemination. In the recent WHO-EORTC classification, the term blastic natural killer cell lymphoma has been replaced with CD4+/CD56+ HN because of its derivation from a plasmacytoid de...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.2.186
更新日期:2010-05-01 00:00:00
abstract::Eosinophic fasciitis (EF) is an uncommon connective tissue disease characterized by scleroderma-like cutaneous changes, peripheral eosinophilia, hypergammaglobulinemia, and an elevated erythrocyte sedimentation rate (ESR). Typical histopathologic findings include chronic inflammatory infiltration affecting the deep fa...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.1.81
更新日期:2011-02-01 00:00:00
abstract::Non-tubecrulosis mycobacterium infections were increasingly reported either pulmonary or extrapulmonary in the past decades. In Taiwan, we noticed several reports about the soft tissue infections caused by rapid growing mycobacterium such as Mycobacterium abscessus, Mycobacterium chelonae, on newspaper, magazines, or ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2014.26.2.236
更新日期:2014-04-01 00:00:00
abstract::Bowen's disease usually manifests as a slowly enlarging erythematous scaly patch or plaque. An uncommon variant of Bowen's disease showing a verrucous appearance has been reported and a distinct variant with a prominent clear cell change on histopathology, in addition to a verrucous surface change, was also reported. ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.4.487
更新日期:2017-08-01 00:00:00
abstract:Background:Atopic dermatitis (AD) is related to a deficiency of delta-6-desaturase, an enzyme responsible for converting linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) as a source of GLA has been of interest in the management of AD. Objective:The aim of this randomized, double-blinded, placebo...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2018.30.4.409
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:There exists a treatment challenge with periungual warts. Topical immunotherapy with diphenylcyclopropenone (DPCP) has recently been reported to be an effective treatment for recalcitrant warts, including periungual types. OBJECTIVE:We aimed to evaluate the effectiveness and preference of topical immunother...
journal_title:Annals of dermatology
pub_type: 杂志文章
doi:10.5021/ad.2013.25.4.434
更新日期:2013-11-01 00:00:00
abstract::Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.2.201
更新日期:2011-05-01 00:00:00
abstract::We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and this was accompanied with fever. A serologic test was positive for IgM varicella zoster antibody and coxsackievirus A16 antibody. The histopathologic examination from the palm reve...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2009.21.1.98
更新日期:2009-02-01 00:00:00
abstract::Acute localized exanthematous pustulosis (ALEP) is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 26-year-old woman presented with multiple erythematous pustules on her face, which had appeared th...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.S3.S368
更新日期:2011-12-01 00:00:00
abstract::Nicolau syndrome is a rare adverse reaction to a variety of intra-muscular drug preparations. The typical presentation is pain around the injection site soon after injection, followed by erythema, livedoid patch, hemorrhagic patch, and finally, necrosis of skin, subcutaneous fat, and muscle tissue. The phenomenon has ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.4.501
更新日期:2011-11-01 00:00:00
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journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2010.22.3.319
更新日期:2010-08-01 00:00:00
abstract::Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typ...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2011.23.4.539
更新日期:2011-11-01 00:00:00
abstract::The Abbé-Estlander flap surgery is a cross-lip procedure that is valuable in repairing a defect on the lower lip using a full-thickness flap, consisting of the skin, muscle and mucosa, from the upper lip. As usefulness and practicality of the flap in reconstruction of lower lip surgical defects in Asian ethnicity have...
journal_title:Annals of dermatology
pub_type:
doi:10.5021/ad.2017.29.2.210
更新日期:2017-04-01 00:00:00