Effects of cholinergic system of dorsal hippocampus of rats on MK-801 induced anxiolytic-like behavior.

Abstract:

RATIONALE:Some investigations have shown that the glutamate receptors play a critical role in cognitive processes such as learning and anxiety. OBJECTIVES:The possible involvement of the cholinergic system of the dorsal hippocampus in the anxiolytic-like response induced by MK-801, NMDA receptor antagonist, was investigated in the present study. METHODS:Male Wistar rats were used in the elevated plus maze apparatus to test the parameters: open arm time (%OAT), open arm entries (%OAE), close arm time (%CAT), close arm entries (%CAE) and other exploratory behaviors (locomotor activity, grooming, rearing and defecation) of anxiety-like response. RESULTS:The data indicated that intra-CA1 administration of MK-801 increased %OAT (2μg/rat) and %OAE (1 and 2μg/rat) while decreased %CAT and %CAE and did not alter other exploratory behaviors, indicating an anxiolytic-like effect. Moreover, intra-hippocampal injections of mecamylamine, a cholinergic receptor antagonists (2μg/rat) and scopolamine (4μg/rat), by themselves, 5min before testing, increased %OAT and %OAE but decreased %CAT and %CAE and did not alter locomotor activity and other exploratory behaviors, suggesting an anxiolytic-like effect. On the other hand, intra-CA1 co-administration of an ineffective dose of scopolamine (3μg/rat), but not mecamylamine (1μg/rat), with an ineffective dose of MK-801 (0.5μg/rat) increased %OAT and %OAE and decreased %CAT and %CAE. The data may indicate the possible involvement of the cholinergic system of the CA1 in the anxiolytic-like response induced by MK-801.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Zarrindast MR,Nasehi M,Piri M,Heidari N

doi

10.1016/j.neulet.2011.08.009

subject

Has Abstract

pub_date

2011-11-14 00:00:00

pages

65-70

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(11)01168-2

journal_volume

505

pub_type

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