Insect cell technology is a versatile and robust vaccine manufacturing platform.

abstract：INTRODUCTION:To describe the impact following a 1-dose Varicella vaccination schedule introduced in Costa Rica in September 2007. Areas covered: This is a retrospective review using epidemiologic surveillance national databases of varicella cases and hospitalizations, period 2000-2015. We analyzed age-related varicella...

journal_title：Expert review of vaccines

authors： Avila-Aguero ML,Ulloa-Gutierrez R,Camacho-Badilla K,Soriano-Fallas A,Arroba-Tijerino R,Morice-Trejos A

更新日期：2017-03-01 00:00:00

abstract：INTRODUCTION:Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, tuberculosis, and malaria are responsible for most human deaths produced by infectious diseases worldwide. Vaccination against HIV requires generation of memory T cells and neutralizing antibodies, mucosal immunity, and stimulation of an inn...

journal_title：Expert review of vaccines

authors： Kilpeläinen A,Maya-Hoyos M,Saubí N,Soto CY,Joseph Munne J

更新日期：2018-11-01 00:00:00

abstract：:Newborns and infants are highly susceptible to infectious diseases, resulting in high mortality and morbidity, particularly in resource-poor settings. Many vaccines require several booster doses, resulting in an extensive vaccine schedule, and yet there is still inadequate protection from some of these diseases. This ...

journal_title：Expert review of vaccines

authors： Flanagan KL,Burl S,Lohman-Payne BL,Plebanski M

更新日期：2010-06-01 00:00:00

abstract：:A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development against positive-strand RNA viruses with global public health impact including alphaviruses and flaviviruses. The DNA-launched vaccine represents the recombinant pla...

journal_title：Expert review of vaccines

authors： Pushko P,Lukashevich IS,Weaver SC,Tretyakova I

更新日期：2016-09-01 00:00:00

abstract：:Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the e...

journal_title：Expert review of vaccines

authors： Simmons O,Magee M,Nemunaitis J

更新日期：2010-03-01 00:00:00

abstract：:The WHO has recently issued updated recommendations for the programmatic use of new-generation typhoid vaccines in high-risk areas of countries where typhoid fever is still endemic. Countries have subsequently been instructed to discuss how these recommendations can be implemented and to develop plans for targeted typ...

journal_title：Expert review of vaccines

authors： DeRoeck D,Ochiai RL,Yang J,Anh DD,Alag V,Clemens JD

更新日期：2008-07-01 00:00:00

abstract：:Introduction: Influenza vaccination is regarded as the most effective way to prevent influenza infection. Due to the rapid genetic changes that influenza viruses undergo, seasonal influenza vaccines must be reformulated and re-administered annually necessitating the evaluation of influenza vaccine effectiveness (VE) e...

journal_title：Expert review of vaccines

authors： Ainslie KEC,Haber M,Orenstein WA

更新日期：2019-06-01 00:00:00

abstract：:Vaccine administration is the second leading cause of febrile seizures (FS). FS occurrence in children is a serious concern because it leads to public apprehension of vaccinations. This review discusses the clinical implications of FS, its potential link to vaccinations and its impact on official recommendations for v...

journal_title：Expert review of vaccines

authors： Principi N,Esposito S

更新日期：2013-08-01 00:00:00

abstract：:Group A Streptococcus (GAS) infections are a significant global cause of morbidity and mortality. GAS diseases disproportionally affect those living in conditions characterized by poverty and social injustice, in both developing countries and in marginalized populations of industrialized nations. In Australia and New ...

journal_title：Expert review of vaccines

authors： Sheel M,Moreland NJ,Fraser JD,Carapetis J

更新日期：2016-01-01 00:00:00

abstract：:Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...

journal_title：Expert review of vaccines

authors： Croft NP,Purcell AW

更新日期：2011-02-01 00:00:00

abstract：:Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates glo...

journal_title：Expert review of vaccines

authors： Wheatley AK,Kent SJ

更新日期：2015-01-01 00:00:00

abstract：:Although mass vaccination of the entire population of an endemic area would be the most cost-effective tool to diminish Leishmania burden, an effective vaccine is not yet commercially available. Practically, vaccines have failed to achieve the required level of protection, possibly owing to the lack of an appropriate ...

journal_title：Expert review of vaccines

authors： Doroud D,Rafati S

更新日期：2012-01-01 00:00:00

abstract：:There is growing interest in immunotherapy for malignant gliomas. This interest stems from a number of immunological observations, together with the failure of conventional therapeutic agents to produce broad and clinically meaningful improvements in survival and quality of life. The challenges faced in translating la...

journal_title：Expert review of vaccines

authors： Fenstermaker RA,Ciesielski MJ

更新日期：2014-03-01 00:00:00

abstract：:Corynebacterium pseudotuberculosis continues to cause considerable economic losses in ovine and caprine herds worldwide, causing caseous lymphadenitis. Nevertheless, the immunology of this disease is relatively unknown. Novel antigens may provide vaccines that are more effective and improve diagnostic methods for bett...

journal_title：Expert review of vaccines

authors： Dorella FA,Pacheco LG,Seyffert N,Portela RW,Meyer R,Miyoshi A,Azevedo V

更新日期：2009-02-01 00:00:00

abstract：:Ebola hemorrhagic fever is one of the most fatal viral diseases worldwide affecting humans and nonhuman primates. Although infections only occur frequently in Central Africa, the virus has the potential to spread globally and is classified as a category A pathogen that could be misused as a bioterrorism agent. As of t...

journal_title：Expert review of vaccines

authors： Marzi A,Feldmann H

更新日期：2014-04-01 00:00:00

abstract：:In the two decades since their initial discovery, DNA vaccines technologies have come a long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still the biggest challenge for practical DNA vaccine use. Many different strategies have been tested in preclinical models to address this proble...

journal_title：Expert review of vaccines

authors： Li L,Petrovsky N

更新日期：2016-01-01 00:00:00

abstract：:In the molecular farming area, transient expression approaches for pharmaceutical proteins production, mainly recombinant monoclonal antibodies and vaccines, were developed almost two decades ago and, to date, these systems basically depend on Agrobacterium-mediated delivery and virus expression machinery. We survey h...

journal_title：Expert review of vaccines

authors： Komarova TV,Baschieri S,Donini M,Marusic C,Benvenuto E,Dorokhov YL

更新日期：2010-08-01 00:00:00

abstract：:Plasmid DNA is a promising vaccine modality that is regularly examined in prime-boost immunization regimens. Recent advances in skin immunity increased our understanding of the sophisticated cutaneous immune network, which revived scientific interest in delivering vaccines to the skin. Intradermal administration of pl...

journal_title：Expert review of vaccines

authors： Elnekave M,Furmanov K,Hovav AH

更新日期：2011-08-01 00:00:00

abstract：:The available vaccines against human papillomavirus have some limitations such as low coverage due to their high cost, reduced immune coverage and the lack of therapeutic effects. Recombinant vaccines produced in plants (genetically engineered using stable or transient expression systems) offer the possibility to obta...

journal_title：Expert review of vaccines

authors： Rosales-Mendoza S,Govea-Alonso DO

更新日期：2015-07-01 00:00:00

abstract：:Tumor-associated antigens (TAAs) have been formulated into vaccines that, combined with adjuvants, cytokines or other strategies to boost the immune response, are now in clinical development. Both humoral and cellular immune responses to TAAs have been generated using these vaccines. This approach relies on the patien...

journal_title：Expert review of vaccines

authors： Acres B,Bonnefoy JY

更新日期：2008-09-01 00:00:00

abstract：:Due to distinct immunological limitations, both infants and elderly individuals are highly susceptible to Streptococcus pneumoniae. Routine immunization of children with the conjugate vaccine over the past decade has substantially reduced incidence of vaccine-serotype related invasive pneumococcal disease in both vacc...

journal_title：Expert review of vaccines

authors： Iyer AS,Ohtola JA,Westerink MA

更新日期：2015-01-01 00:00:00

abstract：:The skin is an attractive target for vaccine delivery. Adjuvants and antigens delivered into the skin can result in potent immune responses and an unmatched safety profile. The heat-labile enterotoxin (LT) from Escherichia coli, which acts both as antigen and adjuvant, has been shown to be delivered to human skin effi...

journal_title：Expert review of vaccines

authors： Glenn GM,Flyer DC,Ellingsworth LR,Frech SA,Frerichs DM,Seid RC,Yu J

更新日期：2007-10-01 00:00:00

abstract：:The disease-fighting power of vaccines has defeated many pathogens and has been credited with global reduction of mortality and morbidity. However, most vaccine developments focus on the enhancement of effector responses with systemic inflammation and the consequences overlooked. Recent evidence shows that systemic in...

journal_title：Expert review of vaccines

authors： Tang DC,Nguyen HH

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:There is a growing interest in developing curative strategies for HIV infection. Therapeutic vaccines are one of the most promising approaches. We will review the current knowledge and the new challenges in this research field. Areas covered: PubMed and ClinicalTrial.gov databases were searched to review t...

journal_title：Expert review of vaccines

authors： Leal L,Lucero C,Gatell JM,Gallart T,Plana M,García F

更新日期：2017-06-01 00:00:00

abstract：:An hypothesis published in 1998 suggested that measles-mumps-rubella vaccine may cause autism as a result of persistent measles virus infection of the gastrointestinal tract. Results of early studies were not supportive and in 2001 a review by the Institute of Medicine concluded that the evidence favors the rejection ...

journal_title：Expert review of vaccines

authors： DeStefano F,Thompson WW

更新日期：2004-02-01 00:00:00

abstract：:With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In th...

journal_title：Expert review of vaccines

authors： Fox CB,Haensler J

更新日期：2013-07-01 00:00:00

abstract：:Therapeutic prospects of particulates are increasingly recognized for vaccination purposes. Compared with biologic particulates, such as live or attenuated bacterial vectors and viral vectors, synthetic particulates may be expected to ease the hurdles of quality assurance and validation in vaccine development and prod...

journal_title：Expert review of vaccines

authors： Thiele L,Merkle HP,Walter E

更新日期：2002-08-01 00:00:00

abstract：INTRODUCTION:It has been almost fifty years since the Towne strain was used by Plotkin and collaborators as the first vaccine candidate for cytomegalovirus (CMV). While that approach showed partial efficacy, there have been a multitude of challenges to improve on the promise of a CMV vaccine. Efforts have been dichotom...

journal_title：Expert review of vaccines

authors： Diamond DJ,La Rosa C,Chiuppesi F,Contreras H,Dadwal S,Wussow F,Bautista S,Nakamura R,Zaia JA

更新日期：2018-10-01 00:00:00

abstract：:Introduction: Precision medicine describes the customization of healthcare tailored to the individual patient. Generally, vaccines are considered as public health tools rather than from the individual patient perspective. However, adult vaccination programs in particular should consider many different factors, at the ...

journal_title：Expert review of vaccines

authors： Park SB,Kim HJ,Cheong HJ

更新日期：2019-06-01 00:00:00

abstract：:Immunocompromised hosts are growing in number and include transplant recipients of solid organs or hematopoietic stem cells, people who have HIV, cancer patients on chemotherapy, patients on immunomodulatory treatments for rheumatologic, gastrointestinal or other conditions, as well as those with other immunocompromis...

journal_title：Expert review of vaccines

authors： Kotton CN

更新日期：2008-07-01 00:00:00