Abstract:
:Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates global influenza surveillance efforts, frequent vaccine reformulation and annual readministration. There is, therefore, tremendous interest in the development of novel strategies to elicit broad and durable protection against both seasonal and pandemic infection. This review presents an overview of candidate universal influenza vaccines designed to elicit cross-protective antibody responses to hemagglutinin. In particular, we focus on the potential impact that widespread pre-existing influenza immunity may play upon the design, testing and deployment of universal influenza vaccines.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Wheatley AK,Kent SJdoi
10.1586/14760584.2015.1068125subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1227-39issue
9eissn
1476-0584issn
1744-8395journal_volume
14pub_type
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
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更新日期:2012-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00
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doi:10.1586/14760584.7.6.833
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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