Abstract:
:Corynebacterium pseudotuberculosis continues to cause considerable economic losses in ovine and caprine herds worldwide, causing caseous lymphadenitis. Nevertheless, the immunology of this disease is relatively unknown. Novel antigens may provide vaccines that are more effective and improve diagnostic methods for better control of this disease. The available commercial vaccines are not able to fully protect susceptible animals, cannot be used in all host species and are not licensed for use in many countries. Recent studies on the genomics of C. pseudotuberculosis and on its molecular determinants of virulence should bring us new alternatives for more effective vaccine formulations.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Dorella FA,Pacheco LG,Seyffert N,Portela RW,Meyer R,Miyoshi A,Azevedo Vdoi
10.1586/14760584.8.2.205subject
Has Abstractpub_date
2009-02-01 00:00:00pages
205-13issue
2eissn
1476-0584issn
1744-8395pii
10.1586/14760584.8.2.205journal_volume
8pub_type
杂志文章,评审abstract::Adjuvants are essential components of most clinically used vaccines. This is because the majority of nonliving vaccines are relatively poor inducers of adaptive immunity unless effective adjuvants are co-administered. Aluminum salts (alum) have been used as adjuvants with great success for almost a century and have be...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.21
更新日期:2011-04-01 00:00:00
abstract::Several new lyssaviruses have emerged in the past decade and it is likely that more remain to be discovered. There are six recognized genotypes of lyssavirus other than the rabies virus (genotype 1). All but one of these has been associated with human cases, with the resulting disease clinically similar to rabies. Rab...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.4.4.533
更新日期:2005-08-01 00:00:00
abstract::More focused research on a mucosal HIV-1 vaccine is needed urgently. An increasing amount of collected data, using heterologous multimodality prime-booster strategies, suggest that an efficient and protective HIV-1 vaccine must generate broad, long-lasting HIV-specific CD8(+) cytotoxic T-lymphocyte and neutralizing an...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.2.203
更新日期:2007-04-01 00:00:00
abstract:INTRODUCTION:Hepatitis A, caused by hepatitis A virus (HAV), is primarily transmitted via the fecal/oral route either through ingestion of contaminated food and water or through direct contact with an infectious person. Prevalence of hepatitis A is strongly correlated with socioeconomic factors, decreasing with increas...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2019.1580578
更新日期:2019-03-01 00:00:00
abstract::Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates glo...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1068125
更新日期:2015-01-01 00:00:00
abstract::This review deals with specific immunotherapy performed with pollen vaccines. Pollen allergens, the immunological mechanism of allergic inflammation and the mechanisms behind successful specific immunotherapy treatment of seasonal pollen allergy shall be discussed. The different approaches to develop improved regimes ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2.1.85
更新日期:2003-02-01 00:00:00
abstract::Nucleic acid vaccines have been gaining attention as an alternative to the standard attenuated pathogen or protein based vaccine. However, an unrealized advantage of using such DNA or RNA based vaccination modalities is the ability to program within these nucleic acids regulatory devices that would provide an immunolo...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.997714
更新日期:2015-02-01 00:00:00
abstract::Singapore was the location of the 3rd Global Vaccine Congress on 4-6 October 2009, and it provided a suitable place for sharing a range of developments, concepts and challenges associated with vaccines. One of the major goals of this meeting was to present a broad and balanced program of research, development, product...
journal_title:Expert review of vaccines
pub_type:
doi:10.1586/erv.09.147
更新日期:2010-01-01 00:00:00
abstract::The Leishmania donovani glycoprotein fraction, known as FML, successfully underwent preclinical and clinical (Phase I-III) vaccine trials against canine visceral leishmaniasis (92-95% of protection and 76-80% of vaccine efficacy) when formulated with a QS21 saponin-containing adjuvant. It became the licensed Leishmune...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.7.6.833
更新日期:2008-08-01 00:00:00
abstract:INTRODUCTION:Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, tuberculosis, and malaria are responsible for most human deaths produced by infectious diseases worldwide. Vaccination against HIV requires generation of memory T cells and neutralizing antibodies, mucosal immunity, and stimulation of an inn...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2018.1534588
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Patent and proprietary medicine vendors (PPMVs) are widespread in communities and can potentially be used to expand access to routine immunization especially in underserved areas. In this study, we aimed to assess their readiness to implement routine immunization in Kano, Nigeria and identify factors associa...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2020.1750379
更新日期:2020-04-01 00:00:00
abstract::Complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs nake...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.09.81
更新日期:2009-10-01 00:00:00
abstract::Infections of humans with Bacillus anthracis are an issue with respect to the biothreat both to civilians and military personnel, infections of individuals by infected livestock in endemic regions and, recently, infections of intravenous drug users injecting anthrax-contaminated heroin. Existing vaccination regimens a...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.981533
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Dendritic cells (DCs) regulate mucosal T-cell immunity and encounter several distinct bacteria of the gut flora, including lactobacilli. Gram-positive lactobacilli have been suggested to play an important role in exerting adjuvanticity effects on innate immune cells at mucosal sites. AIMS & METHODS:In the p...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.7.8.1155
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVES:We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically...
journal_title:Expert review of vaccines
pub_type: 杂志文章,随机对照试验
doi:10.1080/14760584.2019.1547195
更新日期:2019-01-01 00:00:00
abstract::As pregnant women are at increased risk of influenza infection and influenza-related complications, immunization with inactivated influenza vaccine during the influenza season is recommended. Vaccination during pregnancy is considered to provide benefits for both the mothers and their young infants. In 2009, the novel...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.12.67
更新日期:2012-08-01 00:00:00
abstract::In addition to the use of traditional vaccines in the National Immunization Program, the introduction: of additional vaccines in Indonesia appears to be important to further reduce rates of childhood mortality. However, it typically takes at least two decades for additional vaccines to be introduced into the National ...
journal_title:Expert review of vaccines
pub_type: 社论
doi:10.1586/14760584.2014.944165
更新日期:2014-12-01 00:00:00
abstract::The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of pu...
journal_title:Expert review of vaccines
pub_type: 杂志文章,meta分析
doi:10.1586/erv.09.161
更新日期:2010-02-01 00:00:00
abstract::Bovine spongiform encephalopathy in cattle is highly suspected to be orally transmitted to humans through contaminated food, causing new variant Creutzfeldt-Jakob disease. However, no prophylactic procedures against these diseases, such as vaccines, in particular those stimulating mucosal protective immunity, have bee...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.1.75
更新日期:2007-02-01 00:00:00
abstract::The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established the method of in vitro reassembly of SV40 virus-like particles (SV40-VLPs) from VP1-pentamers. In this reassembly, SV40-VLPs can encapsulate approximately 5 kb exogenous DNA shielded by h...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.12.149
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVES:The impact of PCV7 and PCV13 on pneumococcal infections in Kuwait is not known. Therefore we evaluated the impact on pneumococcal serotype distribution and penicillin-non-susceptibility in invasive infections in Kuwait. METHODS:Children < 2 y were given PCV7 from Aug 2006 to Jul 2010 (period I), and PCV13 f...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2016.1198698
更新日期:2016-10-01 00:00:00
abstract::Conventional virus-like particles are usually composed of a single structural protein which spontaneously assembles into particles. L-particles, a little-known type of virus-like particle, are produced as part of the natural infectious process of many, if not all, alpha-herpesviruses. L-particles lack the nucleocapsid...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.1.4.427
更新日期:2002-12-01 00:00:00
abstract::A key challenge to HIV vaccine development is the integration of HIV proviral DNA into the host genome upon infection. Therefore, an optimal vaccine should block infection within hours of viral exposure, providing 'sterilizing immunity' at mucosal sites and in blood via potent, broadly reactive antibody to the HIV env...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.3.4.s105
更新日期:2004-08-01 00:00:00
abstract::The WHO has recently recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries. In countries in the Americas, Europe and Australia that have adopted routine childhood immunization against rotavirus, significant reductions in the burden of severe childhood diarrhea have been ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.17
更新日期:2010-04-01 00:00:00
abstract::C-type lectin receptors (CLRs) are a class of pathogen-recognition receptors that are actively investigated in the field of vaccine delivery. Many of their properties have functions linked to the immune system. These receptors are expressed abundantly on antigen-presenting cells and are considered to be the sentinels ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.7.1005
更新日期:2008-09-01 00:00:00
abstract::In recent years, considerable data has been provided to support the role of the immune system in atherosclerosis. These reports came from studies involving knockout murine models of atherosclerosis and human subjects. The notion that inflammatory mechanisms are operable in atherogenesis has fueled a series of studies ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.3.5.605
更新日期:2004-10-01 00:00:00
abstract::The need for an affordable, safe and effective HIV vaccine has never been greater. As the immunogenicity of all the vaccine vectors being evaluated currently in human populations is limited, novel vaccine strategies are needed to stimulate the innate immune system, to generate high levels of neutralizing antibodies an...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.5.6.827
更新日期:2006-12-01 00:00:00
abstract::Notifications of infant deaths, assumed to be related to the introduction of new pentavalent DTwP-Hib-HBV childhood vaccines, caused, during 2008-2010 in few Asian countries, temporary interruptions of the respective vaccination programs. The sudden appearance of fatal cases was due to increased awareness/publicity an...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.2015.1059759
更新日期:2015-01-01 00:00:00
abstract::Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health. In animal models, cross-protection by vac...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.123
更新日期:2010-11-01 00:00:00
abstract::To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a condition...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.1.3.293
更新日期:2002-10-01 00:00:00