BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control.

abstract：:Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...

journal_title：Expert review of vaccines

authors： Croft NP,Purcell AW

更新日期：2011-02-01 00:00:00

abstract：:Adolescents have the highest rates of meningococcal carriage and transmission. Interrupting the adolescent habitat in order to reduce carriage and transmission within adolescents and to other age groups could help to control meningococcal disease at a population level. Compared to immunization strategies restricted to...

journal_title：Expert review of vaccines

authors： Vetter V,Baxter R,Denizer G,Sáfadi MA,Silfverdal SA,Vyse A,Borrow R

更新日期：2016-05-01 00:00:00

abstract：:C-type lectin receptors (CLRs) are a class of pathogen-recognition receptors that are actively investigated in the field of vaccine delivery. Many of their properties have functions linked to the immune system. These receptors are expressed abundantly on antigen-presenting cells and are considered to be the sentinels ...

journal_title：Expert review of vaccines

authors： Tang CK,Sheng KC,Apostolopoulos V,Pietersz GA

更新日期：2008-09-01 00:00:00

abstract：:Through the continuous efforts of several generations, China has become one of the few countries in the world that is capable of independently addressing all the requirements by the Expanded Program on Immunization. Regulatory science is applied to continuously improve the vaccine regulatory system. Passing the prequa...

journal_title：Expert review of vaccines

authors： Xu M,Liang Z,Xu Y,Wang J

更新日期：2015-05-01 00:00:00

abstract：:Several new lyssaviruses have emerged in the past decade and it is likely that more remain to be discovered. There are six recognized genotypes of lyssavirus other than the rabies virus (genotype 1). All but one of these has been associated with human cases, with the resulting disease clinically similar to rabies. Rab...

journal_title：Expert review of vaccines

authors： Nel LH

更新日期：2005-08-01 00:00:00

abstract：:Neisseria lactamica is a commensal organism that is closely related to Neisseria meningitidis, the causative agent of meningococcal disease. N. lactamica has many antigens in common with N. meningitidis, but it lacks a polysaccharide capsule and the serosubtyping antigen PorA. Carriage studies have demonstrated that N...

journal_title：Expert review of vaccines

authors： Gorringe AR

更新日期：2005-06-01 00:00:00

abstract：:Highly renowned in the vaccines world, Stanley A. Plotkin has worked at many leading institutions throughout his career, and is Emeritus Professor of the University of Pennsylvania and Adjunct Professor of the Johns Hopkins University. In 1991, Plotkin joined Sanofi Pasteur and worked there from 1991 to 1997, and now ...

journal_title：Expert review of vaccines

authors： Plotkin SA,Rees J

更新日期：2014-08-01 00:00:00

abstract：:EVALUATION OF: Donato CM, Ch’ng LS, Boniface KF et al. Identification of strains of RotaTeq rotavirus vaccine in infants with gastroenteritis following routine vaccination. J. Infect. Dis. 206(3), 377–383 (2012).Two live, attenuated rotavirus vaccines, RotaTeq(®) (Merck) and Rotarix(®) (GlaxoSmithKline), have been use...

journal_title：Expert review of vaccines

authors： Bowen MD,Payne DC

更新日期：2012-11-01 00:00:00

abstract：:Francisella tularensis, the causative agent of tularemia, is an organism of concern as a potential biowarfare agent. Progress towards understanding the molecular basis of pathogenicity has been hampered by a lack of tools with which to manipulate the pathogen. However, the availability of genome sequence data for a ra...

journal_title：Expert review of vaccines

authors： Oyston PC,Griffiths R

更新日期：2009-11-01 00:00:00

abstract：:The 5th International Conference on Vaccines for Enteric Diseases (VED) attracted more than 250 delegates, mainly from industrialized countries. A total of 56 papers were presented and 46 posters were displayed to update recent developments in the field of enteric diseases and vaccine development. This 3-day event ena...

journal_title：Expert review of vaccines

authors： Schaetti C

更新日期：2009-12-01 00:00:00

abstract：:Psychological stress has been shown to be associated with poorer antibody levels following vaccination in both animals and humans, although the mechanisms underlying this relationship remain unclear. However, animal research has enabled investigation of how this relationship may be affected by the influence of individ...

journal_title：Expert review of vaccines

authors： Burns V

更新日期：2004-04-01 00:00:00

abstract：:The global burden of disease due to Streptococcus pneumoniae remains high. The licensed 7-valent pneumococcal conjugate vaccine (7vCRM, Prevenar/Prevnar) has successfully reduced invasive disease in the USA, but serotype coverage is incomplete and some evidence suggests that serotype replacement has occurred. Recently...

journal_title：Expert review of vaccines

authors： Prymula R,Schuerman L

更新日期：2009-11-01 00:00:00

abstract：:Plant viruses are emerging as an attractive alternative to stable genetic transformation for the expression of foreign proteins in plants. The main advantages of using this strategy are that viral genomes are small and easy to manipulate, infection of plants with modified viruses is simpler and quicker than the regene...

journal_title：Expert review of vaccines

authors： Cañizares MC,Lomonossoff GP,Nicholson L

更新日期：2005-10-01 00:00:00

abstract：:Complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs nake...

journal_title：Expert review of vaccines

authors： Buonaguro FM,Tornesello ML,Buonaguro L

更新日期：2009-10-01 00:00:00

abstract：:While vaccination continues to be the most successful interventionist health policy to date, infectious disease remains a significant cause of death worldwide. A primary reason that vaccination is not able to generate effective immunity is a lack of appropriate adjuvants capable of initiating the desired immune respon...

journal_title：Expert review of vaccines

authors： Fraser CK,Diener KR,Brown MP,Hayball JD

更新日期：2007-08-01 00:00:00

abstract：:The Keystone Symposia conference, Challenges of Global Vaccine Development, attracted approximately 440 scientists, physicians and students from all around the world. The conference goal was to share newly acquired knowledge regarding vaccine-induced immunity, novel technologies, childhood vaccines, preclinical models...

journal_title：Expert review of vaccines

authors： Gudmundsdotter L,Hallengärd D

更新日期：2008-02-01 00:00:00

abstract：:Singapore was the location of the 3rd Global Vaccine Congress on 4-6 October 2009, and it provided a suitable place for sharing a range of developments, concepts and challenges associated with vaccines. One of the major goals of this meeting was to present a broad and balanced program of research, development, product...

journal_title：Expert review of vaccines

authors： Kyd JM

更新日期：2010-01-01 00:00:00

abstract：:Interview by Jenaid Rees, Commissioning Editor Jeffrey Schlom obtained his PhD from Rutgers University (NJ, USA). After obtaining his PhD, he worked at Columbia University (NY, USA) before moving in 1973 to the National Cancer Institute, National Institutes of Health (MD, USA). Since then he has served as the Chief of...

journal_title：Expert review of vaccines

authors： Schlom J

更新日期：2013-10-01 00:00:00

abstract：:Combination vaccines have been used for many years in the USA as part of the primary infant immunization series. However, the current program still requires up to 24 injections by 18 months of age. The Advisory Committee on Immunization Practices in the USA recommends the use of combination vaccines whenever possible....

journal_title：Expert review of vaccines

authors： White C,Halperin SA,Scheifele DW

更新日期：2009-07-01 00:00:00

abstract：:Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health. In animal models, cross-protection by vac...

journal_title：Expert review of vaccines

authors： Epstein SL,Price GE

更新日期：2010-11-01 00:00:00

abstract：:The WHO has recently issued updated recommendations for the programmatic use of new-generation typhoid vaccines in high-risk areas of countries where typhoid fever is still endemic. Countries have subsequently been instructed to discuss how these recommendations can be implemented and to develop plans for targeted typ...

journal_title：Expert review of vaccines

authors： DeRoeck D,Ochiai RL,Yang J,Anh DD,Alag V,Clemens JD

更新日期：2008-07-01 00:00:00

abstract：:The concept of cancer vaccines is as a therapeutic strategy to immunize the body against cancer antigens that may not be presented by the cancer itself, due to the marked immunosuppressive effects of the disease, which has been demonstrated in many different tumors. ...

journal_title：Expert review of vaccines

authors： Dalgleish AG

更新日期：2004-12-01 00:00:00

abstract：:A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development against positive-strand RNA viruses with global public health impact including alphaviruses and flaviviruses. The DNA-launched vaccine represents the recombinant pla...

journal_title：Expert review of vaccines

authors： Pushko P,Lukashevich IS,Weaver SC,Tretyakova I

更新日期：2016-09-01 00:00:00

abstract：:Conventional virus-like particles are usually composed of a single structural protein which spontaneously assembles into particles. L-particles, a little-known type of virus-like particle, are produced as part of the natural infectious process of many, if not all, alpha-herpesviruses. L-particles lack the nucleocapsid...

journal_title：Expert review of vaccines

authors： Pardoe I,Dargan D

更新日期：2002-12-01 00:00:00

abstract：:The production of long-lived, high-affinity antibodies forms the basis of many successful vaccination strategies. Although much is known of the proteins and pathways of the immune system that lead to the production of these antibodies, there are also many processes that remain unexplained or poorly explained. Some vac...

journal_title：Expert review of vaccines

authors： Randall KL

更新日期：2010-09-01 00:00:00

abstract：:Recombinant, nonreplicating, human adenovirus serotype 5-vectored vaccine, known as MRKAd5, expressing three HIV-1 clade B-derived internal proteins when used in a homologous immunization regimen, did not decrease HIV-1 infection rate nor postinfection virus load in the first Phase IIb proof-of-concept trial. However,...

journal_title：Expert review of vaccines

authors： Hanke T

更新日期：2008-04-01 00:00:00

abstract：:The skin is an attractive target for vaccine delivery. Adjuvants and antigens delivered into the skin can result in potent immune responses and an unmatched safety profile. The heat-labile enterotoxin (LT) from Escherichia coli, which acts both as antigen and adjuvant, has been shown to be delivered to human skin effi...

journal_title：Expert review of vaccines

authors： Glenn GM,Flyer DC,Ellingsworth LR,Frech SA,Frerichs DM,Seid RC,Yu J

更新日期：2007-10-01 00:00:00

abstract：:An urgent need exists for vaccines to prevent infections caused by nontypeable Haemophilus influenzae and Moraxella catarrhalis. These bacteria cause otitis media in children, a clinical problem associated with enormous morbidity and cost. H. influenzae and M. catarrhalis also cause lower respiratory tract infections ...

journal_title：Expert review of vaccines

authors： Murphy TF

更新日期：2005-12-01 00:00:00

abstract：:Active immunotherapy aimed at the stimulation of tumor-specific T cells has established itself within the clinic as a therapeutic option to treat cancer. One strategy is the use of so-called peptides that mimic genuine T-cell epitopes as vaccines to activate tumor-specific T cells. In various clinical trials, differen...

journal_title：Expert review of vaccines

authors： Talebian Yazdi M,Keene KR,Hiemstra PS,van der Burg SH

更新日期：2014-01-01 00:00:00

abstract：:Mucosal vaccines constitute an advantageous immunization approach to achieve broad immunization against widespread diseases; however, improvements in this field are still required to expand their exploitation. As gold nanoparticles are biocompatible and can be easily functionalized with antigens, they have been propos...

journal_title：Expert review of vaccines

authors： Salazar-González JA,González-Ortega O,Rosales-Mendoza S

更新日期：2015-01-01 00:00:00