Immunological mechanisms of specific immunotherapy with pollen vaccines: implications for diagnostics and the development of improved vaccination strategies.

abstract：:Corynebacterium pseudotuberculosis continues to cause considerable economic losses in ovine and caprine herds worldwide, causing caseous lymphadenitis. Nevertheless, the immunology of this disease is relatively unknown. Novel antigens may provide vaccines that are more effective and improve diagnostic methods for bett...

journal_title：Expert review of vaccines

authors： Dorella FA,Pacheco LG,Seyffert N,Portela RW,Meyer R,Miyoshi A,Azevedo V

更新日期：2009-02-01 00:00:00

abstract：:More focused research on a mucosal HIV-1 vaccine is needed urgently. An increasing amount of collected data, using heterologous multimodality prime-booster strategies, suggest that an efficient and protective HIV-1 vaccine must generate broad, long-lasting HIV-specific CD8(+) cytotoxic T-lymphocyte and neutralizing an...

journal_title：Expert review of vaccines

authors： Hinkula J

更新日期：2007-04-01 00:00:00

abstract：:Cancer immunotherapy has recently emerged as an important treatment modality. FDA approval of provenge, ipilimumab and pembrolizumab has started to deliver on the long awaited promise of cancer immunotherapy. Many new modalities of immunotherapies targeting cytotoxic T lymphocytes (CTLs) responses, such as adoptive ce...

journal_title：Expert review of vaccines

authors： Sharma RK,Chheda ZS,Jala VR,Haribabu B

更新日期：2015-04-01 00:00:00

abstract：:Complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs nake...

journal_title：Expert review of vaccines

authors： Buonaguro FM,Tornesello ML,Buonaguro L

更新日期：2009-10-01 00:00:00

abstract：:Peanut-allergen hypersensitivity reactions, which can result in anaphylactic episodes and death, affect approximately 1% of the general population. Currently, strict avoidance of allergenic food is the only available treatment for this food-induced allergic reaction; however, the innocuous presence of trace amounts of...

journal_title：Expert review of vaccines

authors： Miller DS,Brown MP,Howley PM,Hayball JD

更新日期：2012-12-01 00:00:00

abstract：:Tumor-associated antigens (TAAs) have been formulated into vaccines that, combined with adjuvants, cytokines or other strategies to boost the immune response, are now in clinical development. Both humoral and cellular immune responses to TAAs have been generated using these vaccines. This approach relies on the patien...

journal_title：Expert review of vaccines

authors： Acres B,Bonnefoy JY

更新日期：2008-09-01 00:00:00

abstract：:Bovine spongiform encephalopathy in cattle is highly suspected to be orally transmitted to humans through contaminated food, causing new variant Creutzfeldt-Jakob disease. However, no prophylactic procedures against these diseases, such as vaccines, in particular those stimulating mucosal protective immunity, have bee...

journal_title：Expert review of vaccines

authors： Sakaguchi S,Arakawa T

更新日期：2007-02-01 00:00:00

abstract：:Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we currently lack a safe and effective pneumonic plague vaccine. These facts raise concern that Y. pestis may be exploited as a bioweapon...

journal_title：Expert review of vaccines

authors： Smiley ST

更新日期：2008-03-01 00:00:00

abstract：:The global burden of disease due to Streptococcus pneumoniae remains high. The licensed 7-valent pneumococcal conjugate vaccine (7vCRM, Prevenar/Prevnar) has successfully reduced invasive disease in the USA, but serotype coverage is incomplete and some evidence suggests that serotype replacement has occurred. Recently...

journal_title：Expert review of vaccines

authors： Prymula R,Schuerman L

更新日期：2009-11-01 00:00:00

abstract：:Humanitarian aid workers regularly encounter the challenge of setting up functioning surveillance systems immediately after a disaster. Detecting potential outbreaks of diseases, such as cholera, that might arise from disturbed living conditions, displacement and lack of clean water and sanitation is, therefore, extre...

journal_title：Expert review of vaccines

authors： Chaignat CL,Monti V,Soepardi J,Petersen G,Sorensen E,Narain J,Kieny MP

更新日期：2008-05-01 00:00:00

abstract：:Protection against acquisition of fully heterologous, neutralization-resistant SIV was achieved in rhesus monkeys with adenovirus/poxvirus vector-based vaccines. Protection against acquisition of infection required the inclusion of envelope antigens and correlated with the induction of binding antibodies against the E...

journal_title：Expert review of vaccines

authors： Esparza J

更新日期：2012-05-01 00:00:00

abstract：:Due to distinct immunological limitations, both infants and elderly individuals are highly susceptible to Streptococcus pneumoniae. Routine immunization of children with the conjugate vaccine over the past decade has substantially reduced incidence of vaccine-serotype related invasive pneumococcal disease in both vacc...

journal_title：Expert review of vaccines

authors： Iyer AS,Ohtola JA,Westerink MA

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:To describe the impact following a 1-dose Varicella vaccination schedule introduced in Costa Rica in September 2007. Areas covered: This is a retrospective review using epidemiologic surveillance national databases of varicella cases and hospitalizations, period 2000-2015. We analyzed age-related varicella...

journal_title：Expert review of vaccines

authors： Avila-Aguero ML,Ulloa-Gutierrez R,Camacho-Badilla K,Soriano-Fallas A,Arroba-Tijerino R,Morice-Trejos A

更新日期：2017-03-01 00:00:00

abstract：:Vaccine distribution and delivery has become an issue of significant interest, given the threat of a pandemic influenza outbreak and the resulting need for coordinated efforts to distribute and deliver pandemic influenza vaccines into the hands of healthcare workers responsible for administering them. This review prov...

journal_title：Expert review of vaccines

authors： Jacobson SH,Sewell EC,Jokela JA

更新日期：2007-12-01 00:00:00

abstract：:Incredibly, vaccines currently capture only about 2% of the world's pharmaceutical market, despite the fact that they can be credited with saving more lives and preventing more suffering and disability than any other form of medical activity, with the possible exception of the provision of clean water. ...

journal_title：Expert review of vaccines

authors： Andre FE

更新日期：2005-02-01 00:00:00

abstract：:Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the e...

journal_title：Expert review of vaccines

authors： Simmons O,Magee M,Nemunaitis J

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Intranasal influenza vaccines are expected to confer protection among vaccine recipients by successful induction of mucosal immune response in the upper respiratory tract. Though only live attenuated influenza virus vaccines (LAIVs) are licensed and available for intranasal use in humans today, intranasal ...

journal_title：Expert review of vaccines

authors： Sano K,Ainai A,Suzuki T,Hasegawa H

更新日期：2018-08-01 00:00:00

abstract：:Newborns and infants are highly susceptible to infectious diseases, resulting in high mortality and morbidity, particularly in resource-poor settings. Many vaccines require several booster doses, resulting in an extensive vaccine schedule, and yet there is still inadequate protection from some of these diseases. This ...

journal_title：Expert review of vaccines

authors： Flanagan KL,Burl S,Lohman-Payne BL,Plebanski M

更新日期：2010-06-01 00:00:00

abstract：:Introduction: Despite intensive research efforts, there is still no effective prophylactic vaccine available against HIV-1. Currently, substantial efforts are devoted to the development of vaccines aimed at inducing broadly neutralizing antibodies (bNAbs), which are capable of neutralizing most HIV-1 strains. All bNAb...

journal_title：Expert review of vaccines

authors： Del Moral-Sánchez I,Sliepen K

更新日期：2019-11-01 00:00:00

abstract：:With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In th...

journal_title：Expert review of vaccines

authors： Fox CB,Haensler J

更新日期：2013-07-01 00:00:00

abstract：:The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established the method of in vitro reassembly of SV40 virus-like particles (SV40-VLPs) from VP1-pentamers. In this reassembly, SV40-VLPs can encapsulate approximately 5 kb exogenous DNA shielded by h...

journal_title：Expert review of vaccines

authors： Kawano M,Matsui M,Handa H

更新日期：2013-02-01 00:00:00

abstract：:In the two decades since their initial discovery, DNA vaccines technologies have come a long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still the biggest challenge for practical DNA vaccine use. Many different strategies have been tested in preclinical models to address this proble...

journal_title：Expert review of vaccines

authors： Li L,Petrovsky N

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine indicated for use in older adults (≥65 years of age). It contains 60 µg hemagglutinin of each influenza strain, which is four times the hemagglutinin content of standard-dose influenza vaccines, including Fluzone (IIV3-...

journal_title：Expert review of vaccines

authors： Robertson CA,DiazGranados CA,Decker MD,Chit A,Mercer M,Greenberg DP

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically...

journal_title：Expert review of vaccines

authors： Simani OE,Izu A,Nunes MC,Violari A,Cotton MF,Van Niekerk N,Adrian PV,Madhi SA

更新日期：2019-01-01 00:00:00

abstract：:The impact of the heptavalent pneumococcal conjugate vaccine (PCV7) on the natural history of otitis media (OM) has been studied recently. In a high-risk population, PCV7 significantly reduced the risk of recurrent, bilateral or multiple tympanic membrane perforation, as well as the risk of chronic suppurative OM at 9...

journal_title：Expert review of vaccines

authors： Nascimento-Carvalho CM

更新日期：2009-06-01 00:00:00

abstract：:This section deals with how new knowledge of the development of cellular immunity in the neonatal period informs vaccine development and reviews the immune responses of the most vulnerable group of newborns, those born prematurely, to vaccines. It describes how the development of future vaccine strategies relies on a ...

journal_title：Expert review of vaccines

authors： Prescott S

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age-rel...

journal_title：Expert review of vaccines

authors： Cunningham AL,Heineman T

更新日期：2017-07-01 00:00:00

abstract：:Immunocompromised hosts are growing in number and include transplant recipients of solid organs or hematopoietic stem cells, people who have HIV, cancer patients on chemotherapy, patients on immunomodulatory treatments for rheumatologic, gastrointestinal or other conditions, as well as those with other immunocompromis...

journal_title：Expert review of vaccines

authors： Kotton CN

更新日期：2008-07-01 00:00:00

abstract：:Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine for...

journal_title：Expert review of vaccines

authors： Regules JA,Cummings JF,Ockenhouse CF

更新日期：2011-05-01 00:00:00

abstract：:Francisella tularensis, the causative agent of tularemia, is an organism of concern as a potential biowarfare agent. Progress towards understanding the molecular basis of pathogenicity has been hampered by a lack of tools with which to manipulate the pathogen. However, the availability of genome sequence data for a ra...

journal_title：Expert review of vaccines

authors： Oyston PC,Griffiths R

更新日期：2009-11-01 00:00:00