Abstract:
:The global burden of disease due to Streptococcus pneumoniae remains high. The licensed 7-valent pneumococcal conjugate vaccine (7vCRM, Prevenar/Prevnar) has successfully reduced invasive disease in the USA, but serotype coverage is incomplete and some evidence suggests that serotype replacement has occurred. Recently, a new 10-valent pneumococcal nontypeable Haemophilus influenzae (NTHi) protein D (PD) conjugate vaccine (PHiD-CV, Synflorix) has been licensed in more than 40 countries, including Europe, for the prevention of invasive disease and acute otitis media (AOM) due to pneumococcus in infants and children. PHiD-CV is immunogenic in infants when administered as a three-dose primary vaccination in a range of schedules and has a safety profile comparable to that of 7vCRM. Additional serotypes in PHiD-CV (1, 5 and 7F) increase overall serotype coverage and improve coverage in specific age groups and against specific disease syndromes. The use of the PD carrier, which provided protection against AOM caused by NTHi in a large efficacy trial testing a prototype of the final vaccine formulation, suggests that PHiD-CV will also provide some protection against AOM due to NTHi.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Prymula R,Schuerman Ldoi
10.1586/erv.09.113subject
Has Abstractpub_date
2009-11-01 00:00:00pages
1479-500issue
11eissn
1476-0584issn
1744-8395journal_volume
8pub_type
杂志文章,评审abstract::In the Second Conference on Controversies in Vaccination in Adults, leading vaccine experts among manufacturers, physicians, microbiologists, virologists, immunologists and public health specialists came together to discuss recent approaches, developments and strategies in vaccination against worldwide pressing epidem...
journal_title:Expert review of vaccines
pub_type:
doi:10.1586/erv.13.44
更新日期:2013-06-01 00:00:00
abstract::Influenza vaccines remain the primary public health tool in reducing the ever-present burden of influenza and its complications. In seeking more immunogenic, more effective and more broadly cross-protective influenza vaccines, the landscape of influenza vaccines is rapidly expanding, both in near-term advances and nex...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.13.35
更新日期:2013-05-01 00:00:00
abstract::Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.116
更新日期:2010-10-01 00:00:00
abstract::Current influenza vaccines are primarily targeted to induce immunity to the influenza virus strain-specific hemagglutinin antigen and are not effective in controlling outbreaks of new pandemic viruses. An approach for developing universal vaccines is to present highly conserved antigenic epitopes in an immunogenic con...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.12.70
更新日期:2012-08-01 00:00:00
abstract::Lipopolysaccharide (LPS), a dominant component of the Gram-negative bacterial outer membrane, is a strong activator of the innate immune system, and thereby an important determinant in the adaptive immune response following bacterial infection. This adjuvant activity can be harnessed following immunization with bacter...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2015.1026808
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:There is a growing interest in developing curative strategies for HIV infection. Therapeutic vaccines are one of the most promising approaches. We will review the current knowledge and the new challenges in this research field. Areas covered: PubMed and ClinicalTrial.gov databases were searched to review t...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2017.1322513
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Despite high 1-dose vaccination coverage, breakthrough varicella infections still occur. Therefore, 2-dose vaccination is recommended to enhance the immune response to the virus. However, the reported incremental vaccine effectiveness (VE) of 2-dose vaccination varies widely among studies. METHODS:To determ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,meta分析,评审
doi:10.1080/14760584.2018.1433999
更新日期:2018-04-01 00:00:00
abstract:INTRODUCTION:Vaccination against group B Streptococcus (GBS) during pregnancy could provide protection against disease in the mother, fetus, and newborn. Immunity through transplacental acquired antibodies in the newborns could persist through early infancy, reducing the risk of early-onset (<7 days age) and late-onset...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2018.1496021
更新日期:2018-07-01 00:00:00
abstract::An hypothesis published in 1998 suggested that measles-mumps-rubella vaccine may cause autism as a result of persistent measles virus infection of the gastrointestinal tract. Results of early studies were not supportive and in 2001 a review by the Institute of Medicine concluded that the evidence favors the rejection ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.3.1.19
更新日期:2004-02-01 00:00:00
abstract::As pregnant women are considered a high-risk group for severe influenza illness, current recommendations advise vaccination of all pregnant women with inactivated influenza vaccine. Nevertheless, rates of maternal influenza vaccination have historically been low, possibly reflecting ongoing concerns about vaccine safe...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2013.851607
更新日期:2013-12-01 00:00:00
abstract::Introduction: Precision medicine describes the customization of healthcare tailored to the individual patient. Generally, vaccines are considered as public health tools rather than from the individual patient perspective. However, adult vaccination programs in particular should consider many different factors, at the ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2019.1607303
更新日期:2019-06-01 00:00:00
abstract::Recombinant adenovirus vaccines show great promise for generating protective immunity against infectious agents and tumors. Our studies have identified several interesting biological features of the adenovirus vector that influence the T-cell response. Notably, we have demonstrated that following immunization with ade...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.3.347
更新日期:2007-06-01 00:00:00
abstract::Tumor-associated antigens (TAAs) have been formulated into vaccines that, combined with adjuvants, cytokines or other strategies to boost the immune response, are now in clinical development. Both humoral and cellular immune responses to TAAs have been generated using these vaccines. This approach relies on the patien...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.7.889
更新日期:2008-09-01 00:00:00
abstract:INTRODUCTION:The "cloaked" bacterial pathogen that is Chlamydia trachomatis continues to cause sexually transmitted infections (STIs) that adversely affect the health and well-being of children, adolescents and adults globally. The reproductive disease sequelae follow unresolved or untreated chronic or recurrent asympt...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2018.1417044
更新日期:2018-01-01 00:00:00
abstract::Vaccine distribution and delivery has become an issue of significant interest, given the threat of a pandemic influenza outbreak and the resulting need for coordinated efforts to distribute and deliver pandemic influenza vaccines into the hands of healthcare workers responsible for administering them. This review prov...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.6.981
更新日期:2007-12-01 00:00:00
abstract::Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health. In animal models, cross-protection by vac...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.123
更新日期:2010-11-01 00:00:00
abstract::Corynebacterium pseudotuberculosis continues to cause considerable economic losses in ovine and caprine herds worldwide, causing caseous lymphadenitis. Nevertheless, the immunology of this disease is relatively unknown. Novel antigens may provide vaccines that are more effective and improve diagnostic methods for bett...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.8.2.205
更新日期:2009-02-01 00:00:00
abstract::Atherosclerosis is the primary cause of acute myocardial infarction and stroke. It is well established that arterial inflammation in response to accumulation and oxidation of lipoproteins in the vascular wall is the major factor responsible for the development of atherosclerosis. During recent years, it has become app...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.13.4
更新日期:2013-03-01 00:00:00
abstract:INTRODUCTION:Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine indicated for use in older adults (≥65 years of age). It contains 60 µg hemagglutinin of each influenza strain, which is four times the hemagglutinin content of standard-dose influenza vaccines, including Fluzone (IIV3-...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2016.1254044
更新日期:2016-12-01 00:00:00
abstract::Optimal vaccine efficacy requires not only a protective antigen, but also a strong immune activator as an adjuvant. Most viral vaccines, such as influenza vaccines and nonviral genetic vaccines (e.g., DNA vaccines), contain nucleic acids, which appear to act as essential 'built-in' adjuvants. Specific receptors, inclu...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.09.57
更新日期:2009-08-01 00:00:00
abstract::Human papillomavirus (HPV) is widely known as a cause of cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). HPVs related to cancer express two main oncogenes, i.e. E6 and E7, considered as tumorigenic genes; their integration into the host genome results in the abnormal regulation of cell cycle control...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2016.1176533
更新日期:2016-10-01 00:00:00
abstract::Introduction: Controlling the preventable infectious diseases is the main goal of vaccination. Among the vaccines, combined vaccines are of great importance for their social, public health, and economic values. It is stated that the combined vaccines are as efficient and safe as the monovalent vaccines. However, a con...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2020.1843434
更新日期:2020-10-01 00:00:00
abstract::Bovine spongiform encephalopathy in cattle is highly suspected to be orally transmitted to humans through contaminated food, causing new variant Creutzfeldt-Jakob disease. However, no prophylactic procedures against these diseases, such as vaccines, in particular those stimulating mucosal protective immunity, have bee...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.6.1.75
更新日期:2007-02-01 00:00:00
abstract::Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine for...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.57
更新日期:2011-05-01 00:00:00
abstract::This review describes several enzyme-linked immunosorbent assay (ELISA) techniques proposed to replace the neutralization test for detecting neutralization-relevant antibodies to polioviruses in recipients of inactivated poliovirus vaccine and oral poliovirus vaccine, and for seroepidemiologic studies. Comparisons of ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.4.2.167
更新日期:2005-04-01 00:00:00
abstract::Introduction Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has quickly spread around the world. Areas covered This review will discuss the available immunologic and clinical evidence to support the benefit of the influenza, pneumococcal, and tuberculosis vaccines...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2020.1825951
更新日期:2020-10-01 00:00:00
abstract::Interview by Jenaid Rees, Commissioning Editor Jeffrey Schlom obtained his PhD from Rutgers University (NJ, USA). After obtaining his PhD, he worked at Columbia University (NY, USA) before moving in 1973 to the National Cancer Institute, National Institutes of Health (MD, USA). Since then he has served as the Chief of...
journal_title:Expert review of vaccines
pub_type: 传,历史文章,面试
doi:10.1586/14760584.2013.836913
更新日期:2013-10-01 00:00:00
abstract::Protection against acquisition of fully heterologous, neutralization-resistant SIV was achieved in rhesus monkeys with adenovirus/poxvirus vector-based vaccines. Protection against acquisition of infection required the inclusion of envelope antigens and correlated with the induction of binding antibodies against the E...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.12.21
更新日期:2012-05-01 00:00:00
abstract::EVALUATION OF: Donato CM, Ch’ng LS, Boniface KF et al. Identification of strains of RotaTeq rotavirus vaccine in infants with gastroenteritis following routine vaccination. J. Infect. Dis. 206(3), 377–383 (2012).Two live, attenuated rotavirus vaccines, RotaTeq(®) (Merck) and Rotarix(®) (GlaxoSmithKline), have been use...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.12.114
更新日期:2012-11-01 00:00:00
abstract::Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.161
更新日期:2011-02-01 00:00:00