Abstract:
:Introduction: Despite intensive research efforts, there is still no effective prophylactic vaccine available against HIV-1. Currently, substantial efforts are devoted to the development of vaccines aimed at inducing broadly neutralizing antibodies (bNAbs), which are capable of neutralizing most HIV-1 strains. All bNAbs target the HIV-1 envelope glycoprotein (Env), but Env immunizations usually only induce neutralizing antibodies (NAbs) against the sequence-matched virus and not against other strains.Areas covered: We describe the different strategies that have been explored to improve the breadth and potency of anti-HIV-1 NAb responses. The discussed strategies include the application of engineered Env immunogens, optimization of (bNAb) epitopes, different cocktail and sequential vaccination strategies, nanoparticles and nucleic acid-based vaccines.Expert opinion: A combination of the strategies described in this review and future approaches are probably needed to develop an effective HIV-1 vaccine that can induce broad, potent and long-lasting NAb responses.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Del Moral-Sánchez I,Sliepen Kdoi
10.1080/14760584.2019.1690458subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1127-1143issue
11eissn
1476-0584issn
1744-8395journal_volume
18pub_type
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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更新日期:2012-11-01 00:00:00
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更新日期:2011-04-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
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更新日期:2012-05-01 00:00:00
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更新日期:2019-06-01 00:00:00
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