Regulation of cytotoxic T-Lymphocyte trafficking to tumors by chemoattractants: implications for immunotherapy.

abstract：:Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...

journal_title：Expert review of vaccines

authors： Bai X,Borrow R

更新日期：2010-10-01 00:00:00

abstract：:Introduction: For over 40 years, ebolaviruses have been responsible for sporadic outbreaks of severe and often fatal hemorrhagic fever in humans and nonhuman primates across western and central Africa. In December 2013, an unprecedented Ebola virus (EBOV) epidemic began in West Africa and resulted in the largest outbr...

journal_title：Expert review of vaccines

authors： O'Donnell K,Marzi A

更新日期：2020-03-01 00:00:00

abstract：:To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a condition...

journal_title：Expert review of vaccines

authors： Das AT,Zhou X,Vink M,Klaver B,Berkhout B

更新日期：2002-10-01 00:00:00

abstract：:Many vaccine candidates are highly purified, sometimes monomeric antigens and as a result, not very immunogenic. Antigen delivery systems optimize the presentation of antigens. They also play a major role in solving the problem of there being an increasing number of vaccines but limited opportunities in which to inclu...

journal_title：Expert review of vaccines

authors： Kersten G,Hirschberg H

更新日期：2004-08-01 00:00:00

abstract：:The development of novel and increasingly safer vaccines frequently utilizes well-characterized antigens, in particular highly purified proteins or synthetic peptides. In spite of some achievements, this approach is frequently impeded by the fact that such antigens are often poor immunogens when administered alone. Th...

journal_title：Expert review of vaccines

authors： Moser C,Metcalfe IC,Viret JF

更新日期：2003-04-01 00:00:00

abstract：:Highly renowned in the vaccines world, Stanley A. Plotkin has worked at many leading institutions throughout his career, and is Emeritus Professor of the University of Pennsylvania and Adjunct Professor of the Johns Hopkins University. In 1991, Plotkin joined Sanofi Pasteur and worked there from 1991 to 1997, and now ...

journal_title：Expert review of vaccines

authors： Plotkin SA,Rees J

更新日期：2014-08-01 00:00:00

abstract：:The WHO has recently issued updated recommendations for the programmatic use of new-generation typhoid vaccines in high-risk areas of countries where typhoid fever is still endemic. Countries have subsequently been instructed to discuss how these recommendations can be implemented and to develop plans for targeted typ...

journal_title：Expert review of vaccines

authors： DeRoeck D,Ochiai RL,Yang J,Anh DD,Alag V,Clemens JD

更新日期：2008-07-01 00:00:00

abstract：:Lipopolysaccharide (LPS), a dominant component of the Gram-negative bacterial outer membrane, is a strong activator of the innate immune system, and thereby an important determinant in the adaptive immune response following bacterial infection. This adjuvant activity can be harnessed following immunization with bacter...

journal_title：Expert review of vaccines

authors： Zariri A,van der Ley P

更新日期：2015-06-01 00:00:00

abstract：:The bacillus Calmette-Guérin (BCG) vaccine, initially developed to provide protection against TB, also protects against leprosy; and the magnitude of this effect varies. Previous meta-analyses did not provide a summary estimate of the efficacy due to the heterogeneity of the results. We conducted a meta-analysis of pu...

journal_title：Expert review of vaccines

authors： Merle CS,Cunha SS,Rodrigues LC

更新日期：2010-02-01 00:00:00

abstract：:Infections of humans with Bacillus anthracis are an issue with respect to the biothreat both to civilians and military personnel, infections of individuals by infected livestock in endemic regions and, recently, infections of intravenous drug users injecting anthrax-contaminated heroin. Existing vaccination regimens a...

journal_title：Expert review of vaccines

authors： Altmann DM

更新日期：2015-03-01 00:00:00

abstract：:Influenza vaccines remain the primary public health tool in reducing the ever-present burden of influenza and its complications. In seeking more immunogenic, more effective and more broadly cross-protective influenza vaccines, the landscape of influenza vaccines is rapidly expanding, both in near-term advances and nex...

journal_title：Expert review of vaccines

authors： Reber A,Katz J

更新日期：2013-05-01 00:00:00

abstract：:In the molecular farming area, transient expression approaches for pharmaceutical proteins production, mainly recombinant monoclonal antibodies and vaccines, were developed almost two decades ago and, to date, these systems basically depend on Agrobacterium-mediated delivery and virus expression machinery. We survey h...

journal_title：Expert review of vaccines

authors： Komarova TV,Baschieri S,Donini M,Marusic C,Benvenuto E,Dorokhov YL

更新日期：2010-08-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in ...

journal_title：Expert review of vaccines

authors： Khan MN,Ren D,Kaur R,Basha S,Zagursky R,Pichichero ME

更新日期：2016-07-01 00:00:00

abstract：:Although mass vaccination of the entire population of an endemic area would be the most cost-effective tool to diminish Leishmania burden, an effective vaccine is not yet commercially available. Practically, vaccines have failed to achieve the required level of protection, possibly owing to the lack of an appropriate ...

journal_title：Expert review of vaccines

authors： Doroud D,Rafati S

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome, tuberculosis, and malaria are responsible for most human deaths produced by infectious diseases worldwide. Vaccination against HIV requires generation of memory T cells and neutralizing antibodies, mucosal immunity, and stimulation of an inn...

journal_title：Expert review of vaccines

authors： Kilpeläinen A,Maya-Hoyos M,Saubí N,Soto CY,Joseph Munne J

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Human metapneumovirus (hMPV) has become one of the major pathogens causing acute respiratory infections (ARI) mainly affecting young children, immunocompromised patients, and the elderly. Currently there are no licensed vaccines against this virus. Areas covered: Since the discovery of hMPV in 2001, many g...

journal_title：Expert review of vaccines

authors： Márquez-Escobar VA

更新日期：2017-05-01 00:00:00

abstract：:Incredibly, vaccines currently capture only about 2% of the world's pharmaceutical market, despite the fact that they can be credited with saving more lives and preventing more suffering and disability than any other form of medical activity, with the possible exception of the provision of clean water. ...

journal_title：Expert review of vaccines

authors： Andre FE

更新日期：2005-02-01 00:00:00

abstract：:Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the e...

journal_title：Expert review of vaccines

authors： Simmons O,Magee M,Nemunaitis J

更新日期：2010-03-01 00:00:00

abstract：:Toxoplasma gondii, a significant public health risk, is able to infect almost all warm-blooded animals including humans, and it results in economic losses in production animals. In the last three years, a large number of vaccination experiments have been performed to control T. gondii infection, with the target of lim...

journal_title：Expert review of vaccines

authors： Zhang NZ,Wang M,Xu Y,Petersen E,Zhu XQ

更新日期：2015-01-01 00:00:00

abstract：:Several studies have identified an association between Pandemrix(TM), an AS03 adjuvanted pandemic influenza A(H1N1) vaccine, and narcolepsy, a rare and under-diagnosed sleep disorder with a median onset-to-diagnosis interval of ten years. This paper reviews potential sources of bias in published studies and aims to pr...

journal_title：Expert review of vaccines

authors： Wijnans L,Dodd C,de Ridder M,Romio S,Weibel D,Overeem S,Lammers GJ,Bonhoeffer J,Black S,Sturkenboom M

更新日期：2016-05-01 00:00:00

abstract：:The WHO has recently recommended the inclusion of rotavirus vaccine in the national immunization programs of all countries. In countries in the Americas, Europe and Australia that have adopted routine childhood immunization against rotavirus, significant reductions in the burden of severe childhood diarrhea have been ...

journal_title：Expert review of vaccines

authors： Tate JE,Patel MM,Steele AD,Gentsch JR,Payne DC,Cortese MM,Nakagomi O,Cunliffe NA,Jiang B,Neuzil KM,de Oliveira LH,Glass RI,Parashar UD

更新日期：2010-04-01 00:00:00

abstract：:In addition to the use of traditional vaccines in the National Immunization Program, the introduction: of additional vaccines in Indonesia appears to be important to further reduce rates of childhood mortality. However, it typically takes at least two decades for additional vaccines to be introduced into the National ...

journal_title：Expert review of vaccines

authors： Suwantika AA,Postma MJ

更新日期：2014-12-01 00:00:00

abstract：:Ebola hemorrhagic fever is one of the most fatal viral diseases worldwide affecting humans and nonhuman primates. Although infections only occur frequently in Central Africa, the virus has the potential to spread globally and is classified as a category A pathogen that could be misused as a bioterrorism agent. As of t...

journal_title：Expert review of vaccines

authors： Marzi A,Feldmann H

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Neisseria meningitidis causes invasive meningococcal disease (IMD), with the highest incidence observed in infants and young children. Meningococcal serogroups A, B, C, W, X, and Y account for almost all IMD cases worldwide. Available meningococcal vaccines targeting serogroups A, C, W, and Y (MenACWY) inc...

journal_title：Expert review of vaccines

authors： Martinón-Torres F,Serra L,Safadi MAP

更新日期：2020-04-01 00:00:00

abstract：:Buruli disease, caused by Mycobacterium ulcerans, is an emerging infectious disease in tropical areas, particularly West Africa, which can cause deep necrotizing skin lesions, called Buruli ulcer. Buruli disease affects all age groups but about 50% of the cases are diagnosed in children. There is no evidence that Buru...

journal_title：Expert review of vaccines

authors： Huygen K

更新日期：2003-08-01 00:00:00

abstract：INTRODUCTION:Biologic disease-modifying anti-rheumatic drugs (bDMARDS) are increasingly used in clinical practice for a variety of conditions. Due to concerns surrounding persistence of drug levels and resulting immunosuppression, current case reports recommend against live vaccine administration in the first year of l...

journal_title：Expert review of vaccines

authors： Berkhout A,Clark JE,Wen SC

更新日期：2019-05-01 00:00:00

abstract：:Neisseria lactamica is a commensal organism that is closely related to Neisseria meningitidis, the causative agent of meningococcal disease. N. lactamica has many antigens in common with N. meningitidis, but it lacks a polysaccharide capsule and the serosubtyping antigen PorA. Carriage studies have demonstrated that N...

journal_title：Expert review of vaccines

authors： Gorringe AR

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) regulate mucosal T-cell immunity and encounter several distinct bacteria of the gut flora, including lactobacilli. Gram-positive lactobacilli have been suggested to play an important role in exerting adjuvanticity effects on innate immune cells at mucosal sites. AIMS & METHODS:In the p...

journal_title：Expert review of vaccines

authors： Mohamadzadeh M,Klaenhammer TR

更新日期：2008-10-01 00:00:00

abstract：:Due to distinct immunological limitations, both infants and elderly individuals are highly susceptible to Streptococcus pneumoniae. Routine immunization of children with the conjugate vaccine over the past decade has substantially reduced incidence of vaccine-serotype related invasive pneumococcal disease in both vacc...

journal_title：Expert review of vaccines

authors： Iyer AS,Ohtola JA,Westerink MA

更新日期：2015-01-01 00:00:00

abstract：:Singapore was the location of the 3rd Global Vaccine Congress on 4-6 October 2009, and it provided a suitable place for sharing a range of developments, concepts and challenges associated with vaccines. One of the major goals of this meeting was to present a broad and balanced program of research, development, product...

journal_title：Expert review of vaccines

authors： Kyd JM

更新日期：2010-01-01 00:00:00