Abstract:
INTRODUCTION:Biologic disease-modifying anti-rheumatic drugs (bDMARDS) are increasingly used in clinical practice for a variety of conditions. Due to concerns surrounding persistence of drug levels and resulting immunosuppression, current case reports recommend against live vaccine administration in the first year of life for an infant exposed to perinatal bDMARDS. As a result, this significantly impacts receipt of rotavirus vaccination, a vaccine recommended in many countries' national immunization program. Area covered: We have reviewed all available published literature to explore the effect of peripartum bDMARDS exposure on infant immune responses, safety of live vaccines, and vaccine efficacy in the first year of life. Expert opinion: We recommend that otherwise healthy newborns with a history of perinatal exposure to bDMARDS should receive rotavirus vaccinations as per the recommended schedule. Bacille Calmette et Guerin vaccine should be withheld in the first year of life. No additional booster doses of inactivated vaccines are required as they appear to mount adequate immune responses to the routine schedule.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Berkhout A,Clark JE,Wen SCdoi
10.1080/14760584.2019.1599286subject
Has Abstractpub_date
2019-05-01 00:00:00pages
495-504issue
5eissn
1476-0584issn
1744-8395journal_volume
18pub_type
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journal_title:Expert review of vaccines
pub_type: 杂志文章,meta分析
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 社论
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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更新日期:2011-04-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 面试
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更新日期:2014-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2013-04-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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pub_type: 面试
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