Leishmaniasis: focus on the design of nanoparticulate vaccine delivery systems.

abstract：:The Keystone Symposia conference, Challenges of Global Vaccine Development, attracted approximately 440 scientists, physicians and students from all around the world. The conference goal was to share newly acquired knowledge regarding vaccine-induced immunity, novel technologies, childhood vaccines, preclinical models...

journal_title：Expert review of vaccines

authors： Gudmundsdotter L,Hallengärd D

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Biologic disease-modifying anti-rheumatic drugs (bDMARDS) are increasingly used in clinical practice for a variety of conditions. Due to concerns surrounding persistence of drug levels and resulting immunosuppression, current case reports recommend against live vaccine administration in the first year of l...

journal_title：Expert review of vaccines

authors： Berkhout A,Clark JE,Wen SC

更新日期：2019-05-01 00:00:00

abstract：:With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In th...

journal_title：Expert review of vaccines

authors： Fox CB,Haensler J

更新日期：2013-07-01 00:00:00

abstract：:Buruli disease, caused by Mycobacterium ulcerans, is an emerging infectious disease in tropical areas, particularly West Africa, which can cause deep necrotizing skin lesions, called Buruli ulcer. Buruli disease affects all age groups but about 50% of the cases are diagnosed in children. There is no evidence that Buru...

journal_title：Expert review of vaccines

authors： Huygen K

更新日期：2003-08-01 00:00:00

abstract：:Bordetella pertussis, responsible for one of the oldest vaccine-preventable diseases in children, has resurged in North America, Europe, Latin America and many countries around the world. Despite new recommended vaccination strategies for adolescents, pregnant women and adults, mortality is still significant in develo...

journal_title：Expert review of vaccines

authors： Ulloa-Gutierrez R,Boza R,Carvajal-Riggioni D,Baltodano A

更新日期：2011-01-01 00:00:00

abstract：:A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development against positive-strand RNA viruses with global public health impact including alphaviruses and flaviviruses. The DNA-launched vaccine represents the recombinant pla...

journal_title：Expert review of vaccines

authors： Pushko P,Lukashevich IS,Weaver SC,Tretyakova I

更新日期：2016-09-01 00:00:00

abstract：:The 9th Canadian Immunization Conference was held on 5-8 December 2010 in Quebec City, Canada. Over 1000 academic, public health and vaccine industry scientists, nurses, pharmacists, physicians and policy makers attended the conference, which was organized by the Public Health Agency of Canada-Centre for Immunization ...

journal_title：Expert review of vaccines

authors： Langley JM,Naus M

更新日期：2011-04-01 00:00:00

abstract：:Evaluation of: Böckl K, Wild J, Bredl S et al. Altering an artificial Gagpolnef polyprotein and mode of Env co-administration affects the immunogenicity of a clade C HIV-1 DNA vaccine. PLoS ONE 7(4), e34723 (2012). SIV vaccination studies in monkeys have revealed that Env-directed antibodies are critical for protect...

journal_title：Expert review of vaccines

authors： van Montfort T,Sanders RW

更新日期：2012-10-01 00:00:00

abstract：:The 5th International Conference on Vaccines for Enteric Diseases (VED) attracted more than 250 delegates, mainly from industrialized countries. A total of 56 papers were presented and 46 posters were displayed to update recent developments in the field of enteric diseases and vaccine development. This 3-day event ena...

journal_title：Expert review of vaccines

authors： Schaetti C

更新日期：2009-12-01 00:00:00

abstract：:Several new lyssaviruses have emerged in the past decade and it is likely that more remain to be discovered. There are six recognized genotypes of lyssavirus other than the rabies virus (genotype 1). All but one of these has been associated with human cases, with the resulting disease clinically similar to rabies. Rab...

journal_title：Expert review of vaccines

authors： Nel LH

更新日期：2005-08-01 00:00:00

abstract：:Adjuvants are essential components of most clinically used vaccines. This is because the majority of nonliving vaccines are relatively poor inducers of adaptive immunity unless effective adjuvants are co-administered. Aluminum salts (alum) have been used as adjuvants with great success for almost a century and have be...

journal_title：Expert review of vaccines

authors： Schijns VE,Lavelle EC

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Neisseria meningitidis causes invasive meningococcal disease (IMD), with the highest incidence observed in infants and young children. Meningococcal serogroups A, B, C, W, X, and Y account for almost all IMD cases worldwide. Available meningococcal vaccines targeting serogroups A, C, W, and Y (MenACWY) inc...

journal_title：Expert review of vaccines

authors： Martinón-Torres F,Serra L,Safadi MAP

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Intranasal influenza vaccines are expected to confer protection among vaccine recipients by successful induction of mucosal immune response in the upper respiratory tract. Though only live attenuated influenza virus vaccines (LAIVs) are licensed and available for intranasal use in humans today, intranasal ...

journal_title：Expert review of vaccines

authors： Sano K,Ainai A,Suzuki T,Hasegawa H

更新日期：2018-08-01 00:00:00

abstract：:Lipopolysaccharide (LPS), a dominant component of the Gram-negative bacterial outer membrane, is a strong activator of the innate immune system, and thereby an important determinant in the adaptive immune response following bacterial infection. This adjuvant activity can be harnessed following immunization with bacter...

journal_title：Expert review of vaccines

authors： Zariri A,van der Ley P

更新日期：2015-06-01 00:00:00

abstract：:Dr Tamar Ben-Yedidia has more than 15 years of experience in the field of immunology, with specific expertise in the development of vaccines. She started her career with Biotechnology General Ltd (BTG; Rehovot, Israel), working on the development of a recombinant hepatitis B vaccine. She joined the Weizmann Institute ...

journal_title：Expert review of vaccines

authors： Ben-Yedidia T

更新日期：2010-03-01 00:00:00

abstract：:Vaccination has been a successful tool in the protection against many infectious diseases, and recent advances in biotechnology have created new techniques and strategies to produce safe and efficacious vaccines for human use. However, developing a protective vaccine against malaria has been a challenge. In this artic...

journal_title：Expert review of vaccines

authors： Coban C,Horii T,Akira S,Ishii KJ

更新日期：2010-07-01 00:00:00

abstract：:Bovine spongiform encephalopathy in cattle is highly suspected to be orally transmitted to humans through contaminated food, causing new variant Creutzfeldt-Jakob disease. However, no prophylactic procedures against these diseases, such as vaccines, in particular those stimulating mucosal protective immunity, have bee...

journal_title：Expert review of vaccines

authors： Sakaguchi S,Arakawa T

更新日期：2007-02-01 00:00:00

abstract：:This section deals with how new knowledge of the development of cellular immunity in the neonatal period informs vaccine development and reviews the immune responses of the most vulnerable group of newborns, those born prematurely, to vaccines. It describes how the development of future vaccine strategies relies on a ...

journal_title：Expert review of vaccines

authors： Prescott S

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically...

journal_title：Expert review of vaccines

authors： Simani OE,Izu A,Nunes MC,Violari A,Cotton MF,Van Niekerk N,Adrian PV,Madhi SA

更新日期：2019-01-01 00:00:00

abstract：:As pregnant women are considered a high-risk group for severe influenza illness, current recommendations advise vaccination of all pregnant women with inactivated influenza vaccine. Nevertheless, rates of maternal influenza vaccination have historically been low, possibly reflecting ongoing concerns about vaccine safe...

journal_title：Expert review of vaccines

authors： Fell DB,Dodds L,MacDonald NE,Allen VM,McNeil S

更新日期：2013-12-01 00:00:00

abstract：:Baculovirus and insect cell culture technologies have mostly been limited to research laboratories for the transient expression of target proteins for drug development purposes. With the renaissance of the vaccine field and the regulatory acceptance of recombinant DNA technology, the baculovirus expression system has ...

journal_title：Expert review of vaccines

authors： Mena JA,Kamen AA

更新日期：2011-07-01 00:00:00

abstract：:To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a condition...

journal_title：Expert review of vaccines

authors： Das AT,Zhou X,Vink M,Klaver B,Berkhout B

更新日期：2002-10-01 00:00:00

abstract：:Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the e...

journal_title：Expert review of vaccines

authors： Simmons O,Magee M,Nemunaitis J

更新日期：2010-03-01 00:00:00

abstract：:Many vaccine candidates are highly purified, sometimes monomeric antigens and as a result, not very immunogenic. Antigen delivery systems optimize the presentation of antigens. They also play a major role in solving the problem of there being an increasing number of vaccines but limited opportunities in which to inclu...

journal_title：Expert review of vaccines

authors： Kersten G,Hirschberg H

更新日期：2004-08-01 00:00:00

abstract：:Through the continuous efforts of several generations, China has become one of the few countries in the world that is capable of independently addressing all the requirements by the Expanded Program on Immunization. Regulatory science is applied to continuously improve the vaccine regulatory system. Passing the prequa...

journal_title：Expert review of vaccines

authors： Xu M,Liang Z,Xu Y,Wang J

更新日期：2015-05-01 00:00:00

abstract：:Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...

journal_title：Expert review of vaccines

authors： Croft NP,Purcell AW

更新日期：2011-02-01 00:00:00

abstract：:Infections of humans with Bacillus anthracis are an issue with respect to the biothreat both to civilians and military personnel, infections of individuals by infected livestock in endemic regions and, recently, infections of intravenous drug users injecting anthrax-contaminated heroin. Existing vaccination regimens a...

journal_title：Expert review of vaccines

authors： Altmann DM

更新日期：2015-03-01 00:00:00

abstract：:Complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs nake...

journal_title：Expert review of vaccines

authors： Buonaguro FM,Tornesello ML,Buonaguro L

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Due to overcome the hardness of the vaccine design, computational vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing analysis, antigenicity analysis, population coverage, conservancy analysis, allergenicity assessment, toxicity prediction, and protein-peptide docki...

journal_title：Expert review of vaccines

authors： Kardani K,Bolhassani A,Namvar A

更新日期：2020-08-01 00:00:00

abstract：:Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhanceme...

journal_title：Expert review of vaccines

authors： Borrow R,Dagan R,Zepp F,Hallander H,Poolman J

更新日期：2011-11-01 00:00:00