Abstract:
:In the two decades since their initial discovery, DNA vaccines technologies have come a long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still the biggest challenge for practical DNA vaccine use. Many different strategies have been tested in preclinical models to address this problem, including novel plasmid vectors and codon optimization to enhance antigen expression, new gene transfection systems or electroporation to increase delivery efficiency, protein or live virus vector boosting regimens to maximise immune stimulation, and formulation of DNA vaccines with traditional or molecular adjuvants. Better understanding of the mechanisms of action of DNA vaccines has also enabled better use of the intrinsic host response to DNA to improve vaccine immunogenicity. This review summarizes recent advances in DNA vaccine technologies and related intracellular events and how these might impact on future directions of DNA vaccine development.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Li L,Petrovsky Ndoi
10.1586/14760584.2016.1124762subject
Has Abstractpub_date
2016-01-01 00:00:00pages
313-29issue
3eissn
1476-0584issn
1744-8395journal_volume
15pub_type
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journal_title:Expert review of vaccines
pub_type: 历史文章,杂志文章,评审
doi:10.1586/14760584.2015.1012503
更新日期:2015-05-01 00:00:00
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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pub_type: 传,历史文章,面试
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pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00
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pub_type: 评论,杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.7.7.1005
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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