Abstract:
:Therapeutic prospects of particulates are increasingly recognized for vaccination purposes. Compared with biologic particulates, such as live or attenuated bacterial vectors and viral vectors, synthetic particulates may be expected to ease the hurdles of quality assurance and validation in vaccine development and production and shorten the time for approval and to the market. The ability of synthetic antigen-loaded particulates to elicit strong immune responses, even with low amounts of antigen and to weakly immunogenic epitopes, is suggested to be due to their efficient cross-talk with the most potent antigen-presenting cells, such as dendritic cells. Moreover, the potential of particulates for intracellular delivery and directing intracellular trafficking of antigens has evolved as a promising opportunity to target the major histocompatibility complex I pathway. In summary, synthetic particulate vaccine delivery systems are likely to play an increasingly active role in enhancing or even enabling the immunostimulating effect of antigens upon direct interaction with the target cells.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Thiele L,Merkle HP,Walter Edoi
10.1586/14760584.1.2.215keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
215-26issue
2eissn
1476-0584issn
1744-8395pii
ERV010213journal_volume
1pub_type
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Expert review of vaccines
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更新日期:2018-04-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.166
更新日期:2012-01-01 00:00:00
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journal_title:Expert review of vaccines
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doi:10.1586/14760584.7.6.721
更新日期:2008-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2002-12-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Expert review of vaccines
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doi:10.1586/14760584.2013.851607
更新日期:2013-12-01 00:00:00
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00