Abstract:
:A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development against positive-strand RNA viruses with global public health impact including alphaviruses and flaviviruses. The DNA-launched vaccine represents the recombinant plasmid that encodes the full-length genomic RNA of live-attenuated virus downstream from a eukaryotic promoter. When administered in vivo, the genomic RNA of live-attenuated virus is transcribed. The RNA initiates limited replication of a genetically defined, live-attenuated vaccine virus in the tissues of the vaccine recipient, thereby inducing a protective immune response. This platform combines the strengths of reverse genetics, DNA immunization and the advantages of live-attenuated vaccines, resulting in a reduced chance of genetic reversions, increased safety, and improved immunization. With this vaccine technology, the field of DNA vaccines is expanded from those that express subunit antigens to include a novel type of DNA vaccines that launch live-attenuated viruses.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Pushko P,Lukashevich IS,Weaver SC,Tretyakova Idoi
10.1080/14760584.2016.1175943subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1223-34issue
9eissn
1476-0584issn
1744-8395journal_volume
15pub_type
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pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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pub_type: 评论,杂志文章
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更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章,评审
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doi:10.1080/14760584.2018.1507743
更新日期:2018-08-01 00:00:00
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更新日期:2011-01-01 00:00:00
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