Abstract:
:Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhancement occurs when two TT conjugates are coadministered. CRM(197) conjugate vaccines induce immune bystander interference when given with diphtheria-tetanus-acellular pertussis vaccines, which reduces responses to coadministered Haemophilus influenzae type b vaccine conjugated to TT. These bystander effects are greater as the amount of CRM(197) administered increases. When large amounts of either TT or CRM(197) are coadministered, dose-related carrier-induced epitopic suppression may occur, affecting immune responses to meningococcal or pneumococcal polysaccharides. These observations have implications for vaccine scheduling. The range of available alternative vaccines means that specific vaccine coadministrations can avoid or reduce CRM(197)-induced interference. Potential interactions arising from new CRM(197) or TT conjugates will need to be thoroughly examined.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Borrow R,Dagan R,Zepp F,Hallander H,Poolman Jdoi
10.1586/erv.11.142subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1621-31issue
11eissn
1476-0584issn
1744-8395journal_volume
10pub_type
杂志文章,评审abstract::Lassa virus (LASV) is the most prevalent arenavirus in West Africa and is responsible for several hundred thousand infections and thousands of deaths annually. The sizeable disease burden, numerous imported cases of Lassa fever (LF) and the possibility that LASV can be used as an agent of biological warfare make a str...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.12.139
更新日期:2013-01-01 00:00:00
abstract::Dengue vaccine introduction will likely occur soon. However, little has been published on international dengue vaccine communication and advocacy. More effort at the international level is required to review, unify and strategically disseminate dengue vaccine knowledge to endemic countries' decision makers and potenti...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1152187
更新日期:2016-01-01 00:00:00
abstract::Baculovirus and insect cell culture technologies have mostly been limited to research laboratories for the transient expression of target proteins for drug development purposes. With the renaissance of the vaccine field and the regulatory acceptance of recombinant DNA technology, the baculovirus expression system has ...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.24
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:We evaluated memory responses and antibody persistence to diphtheria-toxoid, tetanus-toxoid, whole-cell-pertussis (DTwP), and Hepatitis-B vaccines in HIV-unexposed, HIV-exposed-uninfected and HIV-infected children previously randomized to initiate time-limited ART at 6-10 weeks (ART-Immed) or when clinically...
journal_title:Expert review of vaccines
pub_type: 杂志文章,随机对照试验
doi:10.1080/14760584.2019.1547195
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age-rel...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1080/14760584.2017.1329012
更新日期:2017-07-01 00:00:00
abstract::It is generally believed that the role of CD4(+) T cells is to coordinate the different arms of the adaptive immune system to shape an effective response against a pathogen and regulate nonessential or deleterious activities. However, a growing body of evidence suggests that effector CD4(+) T cells can directly displa...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.132
更新日期:2010-12-01 00:00:00
abstract::Buruli disease, caused by Mycobacterium ulcerans, is an emerging infectious disease in tropical areas, particularly West Africa, which can cause deep necrotizing skin lesions, called Buruli ulcer. Buruli disease affects all age groups but about 50% of the cases are diagnosed in children. There is no evidence that Buru...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2.4.561
更新日期:2003-08-01 00:00:00
abstract::Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccin...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1158650
更新日期:2016-08-01 00:00:00
abstract::The production of long-lived, high-affinity antibodies forms the basis of many successful vaccination strategies. Although much is known of the proteins and pathways of the immune system that lead to the production of these antibodies, there are also many processes that remain unexplained or poorly explained. Some vac...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.103
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Neisseria meningitidis causes invasive meningococcal disease (IMD), with the highest incidence observed in infants and young children. Meningococcal serogroups A, B, C, W, X, and Y account for almost all IMD cases worldwide. Available meningococcal vaccines targeting serogroups A, C, W, and Y (MenACWY) inc...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2020.1745070
更新日期:2020-04-01 00:00:00
abstract::Plants offer an attractive alternative for the production and delivery of subunit vaccines. Various antigens have been expressed at sufficiently high levels in plants to render vaccine development practical. An increasing body of evidence demonstrates that these plant-produced antigens can induce immunogenic responses...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2.6.763
更新日期:2003-12-01 00:00:00
abstract::Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold. CpG motifs promote the production of T-helper 1 and pro-inflammatory cytokines and induce the maturation/activation of professional antigen-presen...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2.2.305
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:The impact of PCV7 and PCV13 on pneumococcal infections in Kuwait is not known. Therefore we evaluated the impact on pneumococcal serotype distribution and penicillin-non-susceptibility in invasive infections in Kuwait. METHODS:Children < 2 y were given PCV7 from Aug 2006 to Jul 2010 (period I), and PCV13 f...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1080/14760584.2016.1198698
更新日期:2016-10-01 00:00:00
abstract::Several new TB vaccines are currently undergoing clinical trials. Among the most promising is a vaccine based upon the modified vaccinia virus Ankara-expressing mycobacterial antigen 85A (MVA85A). Given the widespread use of the current TB vaccine, BCG, many of the new TB vaccines are being tested for their ability to...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.11.144
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Dendritic cells (DCs) regulate mucosal T-cell immunity and encounter several distinct bacteria of the gut flora, including lactobacilli. Gram-positive lactobacilli have been suggested to play an important role in exerting adjuvanticity effects on innate immune cells at mucosal sites. AIMS & METHODS:In the p...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.7.8.1155
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Hepatitis A and B are two of the most common vaccine-preventable diseases and vaccination for Hepatitis A virus (HAV) and hepatitis B virus (HBV) is recommended for those at risk of contracting HAV and/or HBV through their occupation, travel or lifestyle. OBJECTIVE:To describe the vaccine efficacy, immunoge...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2016.1150182
更新日期:2016-07-01 00:00:00
abstract::The 11th Annual Conference on Vaccine Research, hosted by the National Foundation for Infectious Disease, attracted approximately 450 leaders in the fields of epidemiology, health economics, immunology and vaccinology, making it the largest scientific meeting devoted exclusively to vaccine research and technology. The...
journal_title:Expert review of vaccines
pub_type:
doi:10.1586/14760584.7.6.721
更新日期:2008-08-01 00:00:00
abstract::The 9th Canadian Immunization Conference was held on 5-8 December 2010 in Quebec City, Canada. Over 1000 academic, public health and vaccine industry scientists, nurses, pharmacists, physicians and policy makers attended the conference, which was organized by the Public Health Agency of Canada-Centre for Immunization ...
journal_title:Expert review of vaccines
pub_type:
doi:10.1586/erv.11.34
更新日期:2011-04-01 00:00:00
abstract::Efforts to develop a meningococcal vaccine that will include coverage against serogroup B disease have largely focused on outer membrane protein antigens. The protection offered by currently licensed outer membrane vesicle (OMV) vaccines is specific to epidemic strains as their immunodominant antigens are highly varia...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.10
更新日期:2011-03-01 00:00:00
abstract::Incredibly, vaccines currently capture only about 2% of the world's pharmaceutical market, despite the fact that they can be credited with saving more lives and preventing more suffering and disability than any other form of medical activity, with the possible exception of the provision of clean water. ...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.4.1.23
更新日期:2005-02-01 00:00:00
abstract::Corynebacterium pseudotuberculosis continues to cause considerable economic losses in ovine and caprine herds worldwide, causing caseous lymphadenitis. Nevertheless, the immunology of this disease is relatively unknown. Novel antigens may provide vaccines that are more effective and improve diagnostic methods for bett...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.8.2.205
更新日期:2009-02-01 00:00:00
abstract::The concept of cancer vaccines is as a therapeutic strategy to immunize the body against cancer antigens that may not be presented by the cancer itself, due to the marked immunosuppressive effects of the disease, which has been demonstrated in many different tumors. ...
journal_title:Expert review of vaccines
pub_type: 杂志文章
doi:10.1586/14760584.3.6.665
更新日期:2004-12-01 00:00:00
abstract::The impact of the heptavalent pneumococcal conjugate vaccine (PCV7) on the natural history of otitis media (OM) has been studied recently. In a high-risk population, PCV7 significantly reduced the risk of recurrent, bilateral or multiple tympanic membrane perforation, as well as the risk of chronic suppurative OM at 9...
journal_title:Expert review of vaccines
pub_type: 评论,杂志文章
doi:10.1586/erv.09.42
更新日期:2009-06-01 00:00:00
abstract::Current treatments for lung cancer are far from optimal. Several immunotherapeutic strategies involving vaccines incorporating different tumor-associated antigens to induce immune responses against tumors are being tested in clinical trials internationally. Although small, benefits have indeed been observed from the e...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.12
更新日期:2010-03-01 00:00:00
abstract::Antigenic changes in influenza virus occur gradually, owing to mutations (antigenic drift), and abruptly, owing to reassortment among subtypes (antigenic shift). Availability of strain-matched vaccines often lags behind these changes, resulting in a shortfall in public health. In animal models, cross-protection by vac...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.123
更新日期:2010-11-01 00:00:00
abstract::The disease-fighting power of vaccines has defeated many pathogens and has been credited with global reduction of mortality and morbidity. However, most vaccine developments focus on the enhancement of effector responses with systemic inflammation and the consequences overlooked. Recent evidence shows that systemic in...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2014.882775
更新日期:2014-03-01 00:00:00
abstract::Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, remains a major cause of morbidity and mortality worldwide. The presence of chronic respiratory illness is a major risk factor for pneumonia, and smoking (the most common cause of chronic obstructive pulmonary disease) is also an importan...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.11.176
更新日期:2012-02-01 00:00:00
abstract::Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.161
更新日期:2011-02-01 00:00:00
abstract::The USA is experiencing a pertussis resurgence that resulted in a 60-year high of 48,000 cases in 2012. Our ability to counteract this resurgence is hampered by the fact that pertussis pathogenesis and immunity to pertussis infection are not well studied. Studies in humans are difficult due to the low frequency of per...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/14760584.2014.946016
更新日期:2014-10-01 00:00:00
abstract::In the molecular farming area, transient expression approaches for pharmaceutical proteins production, mainly recombinant monoclonal antibodies and vaccines, were developed almost two decades ago and, to date, these systems basically depend on Agrobacterium-mediated delivery and virus expression machinery. We survey h...
journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
doi:10.1586/erv.10.85
更新日期:2010-08-01 00:00:00