Advances in vaccine development against the pre-erythrocytic stage of Plasmodium falciparum malaria.

abstract：:Optimal vaccine efficacy requires not only a protective antigen, but also a strong immune activator as an adjuvant. Most viral vaccines, such as influenza vaccines and nonviral genetic vaccines (e.g., DNA vaccines), contain nucleic acids, which appear to act as essential 'built-in' adjuvants. Specific receptors, inclu...

journal_title：Expert review of vaccines

authors： Koyama S,Coban C,Aoshi T,Horii T,Akira S,Ishii KJ

更新日期：2009-08-01 00:00:00

abstract：:The USA is experiencing a pertussis resurgence that resulted in a 60-year high of 48,000 cases in 2012. Our ability to counteract this resurgence is hampered by the fact that pertussis pathogenesis and immunity to pertussis infection are not well studied. Studies in humans are difficult due to the low frequency of per...

journal_title：Expert review of vaccines

authors： Warfel JM,Merkel TJ

更新日期：2014-10-01 00:00:00

abstract：:In recent years, considerable data has been provided to support the role of the immune system in atherosclerosis. These reports came from studies involving knockout murine models of atherosclerosis and human subjects. The notion that inflammatory mechanisms are operable in atherogenesis has fueled a series of studies ...

journal_title：Expert review of vaccines

authors： Harats D,George J

更新日期：2004-10-01 00:00:00

abstract：:Active immunotherapy aimed at the stimulation of tumor-specific T cells has established itself within the clinic as a therapeutic option to treat cancer. One strategy is the use of so-called peptides that mimic genuine T-cell epitopes as vaccines to activate tumor-specific T cells. In various clinical trials, differen...

journal_title：Expert review of vaccines

authors： Talebian Yazdi M,Keene KR,Hiemstra PS,van der Burg SH

更新日期：2014-01-01 00:00:00

abstract：:Notifications of infant deaths, assumed to be related to the introduction of new pentavalent DTwP-Hib-HBV childhood vaccines, caused, during 2008-2010 in few Asian countries, temporary interruptions of the respective vaccination programs. The sudden appearance of fatal cases was due to increased awareness/publicity an...

journal_title：Expert review of vaccines

authors： Herzog C

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:The impact of PCV7 and PCV13 on pneumococcal infections in Kuwait is not known. Therefore we evaluated the impact on pneumococcal serotype distribution and penicillin-non-susceptibility in invasive infections in Kuwait. METHODS:Children < 2 y were given PCV7 from Aug 2006 to Jul 2010 (period I), and PCV13 f...

journal_title：Expert review of vaccines

authors： Mokaddas E,Albert MJ

更新日期：2016-10-01 00:00:00

abstract：:Streptococcus pneumoniae (pneumococcus) is a major cause of worldwide mortality and morbidity, and to a large extent is vaccine-preventable. Nasopharyngeal carriage of pneumococcus precedes disease and is the source of pneumococcal spread between people. The use of vaccine effect on carriage as part of the vaccine lic...

journal_title：Expert review of vaccines

authors： Simell B,Auranen K,Käyhty H,Goldblatt D,Dagan R,O'Brien KL,Pneumococcal Carriage Group.

更新日期：2012-07-01 00:00:00

abstract：:Therapeutic prospects of particulates are increasingly recognized for vaccination purposes. Compared with biologic particulates, such as live or attenuated bacterial vectors and viral vectors, synthetic particulates may be expected to ease the hurdles of quality assurance and validation in vaccine development and prod...

journal_title：Expert review of vaccines

authors： Thiele L,Merkle HP,Walter E

更新日期：2002-08-01 00:00:00

abstract：:Ebola hemorrhagic fever is one of the most fatal viral diseases worldwide affecting humans and nonhuman primates. Although infections only occur frequently in Central Africa, the virus has the potential to spread globally and is classified as a category A pathogen that could be misused as a bioterrorism agent. As of t...

journal_title：Expert review of vaccines

authors： Marzi A,Feldmann H

更新日期：2014-04-01 00:00:00

abstract：:A key challenge to HIV vaccine development is the integration of HIV proviral DNA into the host genome upon infection. Therefore, an optimal vaccine should block infection within hours of viral exposure, providing 'sterilizing immunity' at mucosal sites and in blood via potent, broadly reactive antibody to the HIV env...

journal_title：Expert review of vaccines

authors： Malkevitch NV,Robert-Guroff M

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:Intranasal influenza vaccines are expected to confer protection among vaccine recipients by successful induction of mucosal immune response in the upper respiratory tract. Though only live attenuated influenza virus vaccines (LAIVs) are licensed and available for intranasal use in humans today, intranasal ...

journal_title：Expert review of vaccines

authors： Sano K,Ainai A,Suzuki T,Hasegawa H

更新日期：2018-08-01 00:00:00

abstract：:Introduction: Influenza vaccination is regarded as the most effective way to prevent influenza infection. Due to the rapid genetic changes that influenza viruses undergo, seasonal influenza vaccines must be reformulated and re-administered annually necessitating the evaluation of influenza vaccine effectiveness (VE) e...

journal_title：Expert review of vaccines

authors： Ainslie KEC,Haber M,Orenstein WA

更新日期：2019-06-01 00:00:00

abstract：:Recombinant modified vaccinia virus Ankara (MVA) is attractive and promising as a novel viral vector for the expression of foreign genes of interest because it possesses unique properties. In particular, its excellent safety profile and the availability of versatile vector technologies have frequently made MVA the vac...

journal_title：Expert review of vaccines

authors： Rimmelzwaan GF,Sutter G

更新日期：2009-04-01 00:00:00

abstract：:Peptide vaccines represent a potential strategy for the prevention and treatment of pathogenic diseases, cancers and autoimmune disorders; their low cost, ease of synthesis and inherent safety are all attractive features. However, they have remained largely unsuccessful owing to low immunogenicity, predominantly stemm...

journal_title：Expert review of vaccines

authors： Croft NP,Purcell AW

更新日期：2011-02-01 00:00:00

abstract：:Efforts to develop a meningococcal vaccine that will include coverage against serogroup B disease have largely focused on outer membrane protein antigens. The protection offered by currently licensed outer membrane vesicle (OMV) vaccines is specific to epidemic strains as their immunodominant antigens are highly varia...

journal_title：Expert review of vaccines

authors： Sanders H,Feavers IM

更新日期：2011-03-01 00:00:00

abstract：:Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, remains a major cause of morbidity and mortality worldwide. The presence of chronic respiratory illness is a major risk factor for pneumonia, and smoking (the most common cause of chronic obstructive pulmonary disease) is also an importan...

journal_title：Expert review of vaccines

authors： Vila-Corcoles A,Ochoa-Gondar O

更新日期：2012-02-01 00:00:00

abstract：:Pneumococcal disease is a major health problem worldwide. Large, rapid declines in overall invasive pneumococcal disease and mucosal disease in children, reductions in vaccine-type disease in unvaccinated children and adults (indirect effects) and significant drops in antibiotic-resistant infections were observed afte...

journal_title：Expert review of vaccines

authors： Dinleyici EC,Yargic ZA

更新日期：2008-11-01 00:00:00

abstract：:Influenza inflicts significant global mortality and morbidity that can be combated by effective immunization. However, the protective efficacy of current vaccines is limited by both the significant antigenic diversity of the viral hemagglutinin protein and the capacity for rapid antigenic change. This necessitates glo...

journal_title：Expert review of vaccines

authors： Wheatley AK,Kent SJ

更新日期：2015-01-01 00:00:00

abstract：:Extensive efforts aimed at stimulating immune responses by modifying HIV antigens and using various delivery systems and adjuvants have so far failed to generate promising HIV vaccines, highlighting the urgent need to explore alternative immunization approaches. Antigen-presenting cells, such as dendritic cells, play ...

journal_title：Expert review of vaccines

authors： Song XT,Aldrich M,Chen SY

更新日期：2006-08-01 00:00:00

abstract：:Several new TB vaccines are currently undergoing clinical trials. Among the most promising is a vaccine based upon the modified vaccinia virus Ankara-expressing mycobacterial antigen 85A (MVA85A). Given the widespread use of the current TB vaccine, BCG, many of the new TB vaccines are being tested for their ability to...

journal_title：Expert review of vaccines

authors： McMurray DN

更新日期：2011-12-01 00:00:00

abstract：:Malaria continues to be a worldwide leading cause of morbidity and mortality, and the development of an effective malaria vaccine remains a research imperative. Of the multiple approaches that have been pursued, the RTS,S/AS01 vaccine candidate represents the most developed and clinically validated malaria vaccine for...

journal_title：Expert review of vaccines

authors： Regules JA,Cummings JF,Ockenhouse CF

更新日期：2011-05-01 00:00:00

abstract：:Recombinant, nonreplicating, human adenovirus serotype 5-vectored vaccine, known as MRKAd5, expressing three HIV-1 clade B-derived internal proteins when used in a homologous immunization regimen, did not decrease HIV-1 infection rate nor postinfection virus load in the first Phase IIb proof-of-concept trial. However,...

journal_title：Expert review of vaccines

authors： Hanke T

更新日期：2008-04-01 00:00:00

abstract：:The aging process in humans is associated with a decrease in immune function (immunosenescence) and an increase in comorbid disorders. When combined with environmental factors this can lead to an increased risk and severity of infectious diseases. Diseases in older adults (>/=70 years) tend to be more severe and have ...

journal_title：Expert review of vaccines

authors： Maggi S

更新日期：2010-03-01 00:00:00

abstract：:The success of vaccine regimens against viral pathogens hinges on the elicitation of protective responses. Hypervariable pathogens such as HIV avoid neutralization by masking protective epitopes with more immunogenic decoys. The identification of protective, conserved epitopes is crucial for future vaccine candidate d...

journal_title：Expert review of vaccines

authors： Kramer VG,Byrareddy SN

更新日期：2014-08-01 00:00:00

abstract：:C-type lectin receptors (CLRs) are a class of pathogen-recognition receptors that are actively investigated in the field of vaccine delivery. Many of their properties have functions linked to the immune system. These receptors are expressed abundantly on antigen-presenting cells and are considered to be the sentinels ...

journal_title：Expert review of vaccines

authors： Tang CK,Sheng KC,Apostolopoulos V,Pietersz GA

更新日期：2008-09-01 00:00:00

abstract：:Serogroup B Neisseria meningitidis is the leading cause of meningococcal disease in developed countries. There is currently no vaccine offering wide-ranging protection. Development of a serogroup B polysaccharide-based vaccine has been hindered by potential risks of autoantibodies that cross-react with glycosylated ho...

journal_title：Expert review of vaccines

authors： Bai X,Borrow R

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Fluzone® High-Dose (IIV3-HD) is a trivalent, inactivated, split-virus influenza vaccine indicated for use in older adults (≥65 years of age). It contains 60 µg hemagglutinin of each influenza strain, which is four times the hemagglutinin content of standard-dose influenza vaccines, including Fluzone (IIV3-...

journal_title：Expert review of vaccines

authors： Robertson CA,DiazGranados CA,Decker MD,Chit A,Mercer M,Greenberg DP

更新日期：2016-12-01 00:00:00

abstract：:Combination vaccines have been used for many years in the USA as part of the primary infant immunization series. However, the current program still requires up to 24 injections by 18 months of age. The Advisory Committee on Immunization Practices in the USA recommends the use of combination vaccines whenever possible....

journal_title：Expert review of vaccines

authors： White C,Halperin SA,Scheifele DW

更新日期：2009-07-01 00:00:00

abstract：:Cancer immunotherapy has recently emerged as an important treatment modality. FDA approval of provenge, ipilimumab and pembrolizumab has started to deliver on the long awaited promise of cancer immunotherapy. Many new modalities of immunotherapies targeting cytotoxic T lymphocytes (CTLs) responses, such as adoptive ce...

journal_title：Expert review of vaccines

authors： Sharma RK,Chheda ZS,Jala VR,Haribabu B

更新日期：2015-04-01 00:00:00

abstract：:The 9th Canadian Immunization Conference was held on 5-8 December 2010 in Quebec City, Canada. Over 1000 academic, public health and vaccine industry scientists, nurses, pharmacists, physicians and policy makers attended the conference, which was organized by the Public Health Agency of Canada-Centre for Immunization ...

journal_title：Expert review of vaccines

authors： Langley JM,Naus M

更新日期：2011-04-01 00:00:00