Recent progress in peptide vaccination in cancer with a focus on non-small-cell lung cancer.

Abstract:

:Active immunotherapy aimed at the stimulation of tumor-specific T cells has established itself within the clinic as a therapeutic option to treat cancer. One strategy is the use of so-called peptides that mimic genuine T-cell epitopes as vaccines to activate tumor-specific T cells. In various clinical trials, different types of vaccines, adjuvants and other immunomodulatory compounds were evaluated in patients with different types of tumors. Here, we review the trials published in the last 3 years focusing on the T-cell response, the effect of immunomodulation and potential relationships with clinical outcomes. Furthermore, we would like to make a case for the development of peptide vaccines aiming to treat non-small-cell lung cancer, the most common cause of cancer mortality.

journal_name

Expert Rev Vaccines

authors

Talebian Yazdi M,Keene KR,Hiemstra PS,van der Burg SH

doi

10.1586/14760584.2014.862499

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

87-116

issue

1

eissn

1476-0584

issn

1744-8395

journal_volume

13

pub_type

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