Immunization: a global challenge for the 21st Century.

abstract：:Several live-attenuated Shigella vaccines, with well-defined mutations in specific genes, have shown great promise in eliciting significant immune responses when given orally to volunteers. These responses have been measured by evaluating antibody-secreting cells, serum antibody levels and fecal immunoglobulin A to ba...

journal_title：Expert review of vaccines

authors： Venkatesan MM,Ranallo RT

更新日期：2006-10-01 00:00:00

abstract：:Complex antigen structures currently represent the most-studied approach for prophylactic as well as therapeutic vaccines. Different types of complex vaccines, including virus-like particles and virosomes, have been developed depending on the nature of the viral pathogen they are trying to replicate (enveloped vs nake...

journal_title：Expert review of vaccines

authors： Buonaguro FM,Tornesello ML,Buonaguro L

更新日期：2009-10-01 00:00:00

abstract：:Peanut-allergen hypersensitivity reactions, which can result in anaphylactic episodes and death, affect approximately 1% of the general population. Currently, strict avoidance of allergenic food is the only available treatment for this food-induced allergic reaction; however, the innocuous presence of trace amounts of...

journal_title：Expert review of vaccines

authors： Miller DS,Brown MP,Howley PM,Hayball JD

更新日期：2012-12-01 00:00:00

abstract：:In the two decades since their initial discovery, DNA vaccines technologies have come a long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still the biggest challenge for practical DNA vaccine use. Many different strategies have been tested in preclinical models to address this proble...

journal_title：Expert review of vaccines

authors： Li L,Petrovsky N

更新日期：2016-01-01 00:00:00

abstract：:To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a condition...

journal_title：Expert review of vaccines

authors： Das AT,Zhou X,Vink M,Klaver B,Berkhout B

更新日期：2002-10-01 00:00:00

abstract：:Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, remains a major cause of morbidity and mortality worldwide. The presence of chronic respiratory illness is a major risk factor for pneumonia, and smoking (the most common cause of chronic obstructive pulmonary disease) is also an importan...

journal_title：Expert review of vaccines

authors： Vila-Corcoles A,Ochoa-Gondar O

更新日期：2012-02-01 00:00:00

abstract：:Immunotherapy is a promising means to fight cancer, prompting a steady increase in clinical trials and correlative laboratory studies in this field. As antitumor T cells play central roles in immunity against malignant diseases, most immunotherapeutic protocols aim to induce and/or strengthen their function. Various t...

journal_title：Expert review of vaccines

authors： Robert-Tissot C,Nguyen LT,Ohashi PS,Speiser DE

更新日期：2013-11-01 00:00:00

abstract：:Several subtypes of influenza A viruses with pandemic potential are endemic in bird populations throughout Asia, Africa and the Middle East, and evidence suggests that these viruses are adapting to the mammalian host. As emphasized by the high mortality rate of humans infected with H5N1 viruses, this situation present...

journal_title：Expert review of vaccines

authors： Barrett PN,Portsmouth D,Ehrlich HJ

更新日期：2013-04-01 00:00:00

abstract：:Atherosclerosis is the primary cause of acute myocardial infarction and stroke. It is well established that arterial inflammation in response to accumulation and oxidation of lipoproteins in the vascular wall is the major factor responsible for the development of atherosclerosis. During recent years, it has become app...

journal_title：Expert review of vaccines

authors： Nilsson J,Wigren M,Shah PK

更新日期：2013-03-01 00:00:00

abstract：:The Keystone Symposia conference, Challenges of Global Vaccine Development, attracted approximately 440 scientists, physicians and students from all around the world. The conference goal was to share newly acquired knowledge regarding vaccine-induced immunity, novel technologies, childhood vaccines, preclinical models...

journal_title：Expert review of vaccines

authors： Gudmundsdotter L,Hallengärd D

更新日期：2008-02-01 00:00:00

abstract：:The global burden of disease due to Streptococcus pneumoniae remains high. The licensed 7-valent pneumococcal conjugate vaccine (7vCRM, Prevenar/Prevnar) has successfully reduced invasive disease in the USA, but serotype coverage is incomplete and some evidence suggests that serotype replacement has occurred. Recently...

journal_title：Expert review of vaccines

authors： Prymula R,Schuerman L

更新日期：2009-11-01 00:00:00

abstract：:The authors have purified a major capsid protein, VP1 of Simian virus 40 (SV40), using recombinant baculovirus and have established the method of in vitro reassembly of SV40 virus-like particles (SV40-VLPs) from VP1-pentamers. In this reassembly, SV40-VLPs can encapsulate approximately 5 kb exogenous DNA shielded by h...

journal_title：Expert review of vaccines

authors： Kawano M,Matsui M,Handa H

更新日期：2013-02-01 00:00:00

abstract：:The production of long-lived, high-affinity antibodies forms the basis of many successful vaccination strategies. Although much is known of the proteins and pathways of the immune system that lead to the production of these antibodies, there are also many processes that remain unexplained or poorly explained. Some vac...

journal_title：Expert review of vaccines

authors： Randall KL

更新日期：2010-09-01 00:00:00

abstract：:Adjuvants are essential components of most clinically used vaccines. This is because the majority of nonliving vaccines are relatively poor inducers of adaptive immunity unless effective adjuvants are co-administered. Aluminum salts (alum) have been used as adjuvants with great success for almost a century and have be...

journal_title：Expert review of vaccines

authors： Schijns VE,Lavelle EC

更新日期：2011-04-01 00:00:00

abstract：:With approximately 2.4 billion people at risk, Plasmodium falciparum malaria infection caused by an infectious bite of an Anopheles mosquito continues to be a major cause of mortality and morbidity, mainly in the tropics and subtropics. Measures to control the mosquito vector on a broad scale are expensive and need to...

journal_title：Expert review of vaccines

authors： Walther M

更新日期：2006-02-01 00:00:00

abstract：:Several studies have identified an association between Pandemrix(TM), an AS03 adjuvanted pandemic influenza A(H1N1) vaccine, and narcolepsy, a rare and under-diagnosed sleep disorder with a median onset-to-diagnosis interval of ten years. This paper reviews potential sources of bias in published studies and aims to pr...

journal_title：Expert review of vaccines

authors： Wijnans L,Dodd C,de Ridder M,Romio S,Weibel D,Overeem S,Lammers GJ,Bonhoeffer J,Black S,Sturkenboom M

更新日期：2016-05-01 00:00:00

abstract：:Influenza vaccines remain the primary public health tool in reducing the ever-present burden of influenza and its complications. In seeking more immunogenic, more effective and more broadly cross-protective influenza vaccines, the landscape of influenza vaccines is rapidly expanding, both in near-term advances and nex...

journal_title：Expert review of vaccines

authors： Reber A,Katz J

更新日期：2013-05-01 00:00:00

abstract：:Singapore was the location of the 3rd Global Vaccine Congress on 4-6 October 2009, and it provided a suitable place for sharing a range of developments, concepts and challenges associated with vaccines. One of the major goals of this meeting was to present a broad and balanced program of research, development, product...

journal_title：Expert review of vaccines

authors： Kyd JM

更新日期：2010-01-01 00:00:00

abstract：:Several new TB vaccines are currently undergoing clinical trials. Among the most promising is a vaccine based upon the modified vaccinia virus Ankara-expressing mycobacterial antigen 85A (MVA85A). Given the widespread use of the current TB vaccine, BCG, many of the new TB vaccines are being tested for their ability to...

journal_title：Expert review of vaccines

authors： McMurray DN

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:It has been almost fifty years since the Towne strain was used by Plotkin and collaborators as the first vaccine candidate for cytomegalovirus (CMV). While that approach showed partial efficacy, there have been a multitude of challenges to improve on the promise of a CMV vaccine. Efforts have been dichotom...

journal_title：Expert review of vaccines

authors： Diamond DJ,La Rosa C,Chiuppesi F,Contreras H,Dadwal S,Wussow F,Bautista S,Nakamura R,Zaia JA

更新日期：2018-10-01 00:00:00

abstract：:With the exception of alum, emulsion-based vaccine adjuvants have been administered to far more people than any other adjuvant, especially since the 2009 H1N1 influenza pandemic. The number of clinical safety and immunogenicity evaluations of vaccines containing emulsion adjuvants has correspondingly mushroomed. In th...

journal_title：Expert review of vaccines

authors： Fox CB,Haensler J

更新日期：2013-07-01 00:00:00

abstract：:The cytotoxic CD8(+) T lymphocyte-mediated cellular response is important for the elimination of virus-infected cells and requires the prior recognition of short viral peptide antigens previously translocated to the endoplasmic reticulum by the transporter associated with antigen processing (TAP). However, individuals...

journal_title：Expert review of vaccines

authors： López D,Lorente E,Barriga A,Johnstone C,Mir C

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Vaccination against group B Streptococcus (GBS) during pregnancy could provide protection against disease in the mother, fetus, and newborn. Immunity through transplacental acquired antibodies in the newborns could persist through early infancy, reducing the risk of early-onset (<7 days age) and late-onset...

journal_title：Expert review of vaccines

authors： Dzanibe S,Madhi SA

更新日期：2018-07-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a predominant organism of the upper respiratory nasopharyngeal microbiota. Its disease spectrum includes otitis media, sinusitis, non-bacteremic pneumonia and invasive infections. Protein-based vaccines to prevent NTHi infections are needed to alleviate these infections in ...

journal_title：Expert review of vaccines

authors： Khan MN,Ren D,Kaur R,Basha S,Zagursky R,Pichichero ME

更新日期：2016-07-01 00:00:00

abstract：:Humanitarian aid workers regularly encounter the challenge of setting up functioning surveillance systems immediately after a disaster. Detecting potential outbreaks of diseases, such as cholera, that might arise from disturbed living conditions, displacement and lack of clean water and sanitation is, therefore, extre...

journal_title：Expert review of vaccines

authors： Chaignat CL,Monti V,Soepardi J,Petersen G,Sorensen E,Narain J,Kieny MP

更新日期：2008-05-01 00:00:00

abstract：:Many vaccine candidates are highly purified, sometimes monomeric antigens and as a result, not very immunogenic. Antigen delivery systems optimize the presentation of antigens. They also play a major role in solving the problem of there being an increasing number of vaccines but limited opportunities in which to inclu...

journal_title：Expert review of vaccines

authors： Kersten G,Hirschberg H

更新日期：2004-08-01 00:00:00

abstract：:More focused research on a mucosal HIV-1 vaccine is needed urgently. An increasing amount of collected data, using heterologous multimodality prime-booster strategies, suggest that an efficient and protective HIV-1 vaccine must generate broad, long-lasting HIV-specific CD8(+) cytotoxic T-lymphocyte and neutralizing an...

journal_title：Expert review of vaccines

authors： Hinkula J

更新日期：2007-04-01 00:00:00

abstract：:Newborns and infants are highly susceptible to infectious diseases, resulting in high mortality and morbidity, particularly in resource-poor settings. Many vaccines require several booster doses, resulting in an extensive vaccine schedule, and yet there is still inadequate protection from some of these diseases. This ...

journal_title：Expert review of vaccines

authors： Flanagan KL,Burl S,Lohman-Payne BL,Plebanski M

更新日期：2010-06-01 00:00:00

abstract：:Neisseria lactamica is a commensal organism that is closely related to Neisseria meningitidis, the causative agent of meningococcal disease. N. lactamica has many antigens in common with N. meningitidis, but it lacks a polysaccharide capsule and the serosubtyping antigen PorA. Carriage studies have demonstrated that N...

journal_title：Expert review of vaccines

authors： Gorringe AR

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Biologic disease-modifying anti-rheumatic drugs (bDMARDS) are increasingly used in clinical practice for a variety of conditions. Due to concerns surrounding persistence of drug levels and resulting immunosuppression, current case reports recommend against live vaccine administration in the first year of l...

journal_title：Expert review of vaccines

authors： Berkhout A,Clark JE,Wen SC

更新日期：2019-05-01 00:00:00