Peptidomimetics: modifying peptides in the pursuit of better vaccines.

abstract：:Neisseria lactamica is a commensal organism that is closely related to Neisseria meningitidis, the causative agent of meningococcal disease. N. lactamica has many antigens in common with N. meningitidis, but it lacks a polysaccharide capsule and the serosubtyping antigen PorA. Carriage studies have demonstrated that N...

journal_title：Expert review of vaccines

authors： Gorringe AR

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Although much progress has been made in the last decade(s) toward development of effective cancer vaccines, there are still important obstacles to therapeutic successes. New generations of cancer vaccines will benefit from a combination adjuvant approach that targets multiple branches of the immune respons...

journal_title：Expert review of vaccines

authors： Bowen WS,Svrivastava AK,Batra L,Barsoumian H,Shirwan H

更新日期：2018-03-01 00:00:00

abstract：:Synthetic oligodeoxynucleotides containing unmethylated CpG motifs act as immune adjuvants, accelerating and boosting antigen-specific antibody responses by up to 500-fold. CpG motifs promote the production of T-helper 1 and pro-inflammatory cytokines and induce the maturation/activation of professional antigen-presen...

journal_title：Expert review of vaccines

authors： Klinman DM

更新日期：2003-04-01 00:00:00

abstract：:Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhanceme...

journal_title：Expert review of vaccines

authors： Borrow R,Dagan R,Zepp F,Hallander H,Poolman J

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:Due to overcome the hardness of the vaccine design, computational vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing analysis, antigenicity analysis, population coverage, conservancy analysis, allergenicity assessment, toxicity prediction, and protein-peptide docki...

journal_title：Expert review of vaccines

authors： Kardani K,Bolhassani A,Namvar A

更新日期：2020-08-01 00:00:00

abstract：:The available vaccines against human papillomavirus have some limitations such as low coverage due to their high cost, reduced immune coverage and the lack of therapeutic effects. Recombinant vaccines produced in plants (genetically engineered using stable or transient expression systems) offer the possibility to obta...

journal_title：Expert review of vaccines

authors： Rosales-Mendoza S,Govea-Alonso DO

更新日期：2015-07-01 00:00:00

abstract：:Streptococcus pneumoniae, the most common cause of community-acquired pneumonia, remains a major cause of morbidity and mortality worldwide. The presence of chronic respiratory illness is a major risk factor for pneumonia, and smoking (the most common cause of chronic obstructive pulmonary disease) is also an importan...

journal_title：Expert review of vaccines

authors： Vila-Corcoles A,Ochoa-Gondar O

更新日期：2012-02-01 00:00:00

abstract：:The production of long-lived, high-affinity antibodies forms the basis of many successful vaccination strategies. Although much is known of the proteins and pathways of the immune system that lead to the production of these antibodies, there are also many processes that remain unexplained or poorly explained. Some vac...

journal_title：Expert review of vaccines

authors： Randall KL

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Pertussis is a highly contagious disease of the respiratory tract which is caused by the bacterium Bordetella pertussis and is most severe in those <1 year of age. A vaccine against pertussis, introduced in the 1950's, led to a significant decrease in incidence of the disease, but recent increases in outbr...

journal_title：Expert review of vaccines

authors： Martinón-Torres F,Heininger U,Thomson A,Wirsing von König CH

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Meningococcal disease has an incidence peak spread over several years during adolescence and young adulthood in the United States. Meningococcal serogroup B (MenB) vaccines have been introduced relatively recently and may help protect individuals in these age groups. Currently there is insufficient long-te...

journal_title：Expert review of vaccines

authors： Watson PS,Novy P,Bekkat-Berkani R,Strubbe F,Banzhoff A

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:There is a growing interest in developing curative strategies for HIV infection. Therapeutic vaccines are one of the most promising approaches. We will review the current knowledge and the new challenges in this research field. Areas covered: PubMed and ClinicalTrial.gov databases were searched to review t...

journal_title：Expert review of vaccines

authors： Leal L,Lucero C,Gatell JM,Gallart T,Plana M,García F

更新日期：2017-06-01 00:00:00

abstract：:Although mass vaccination of the entire population of an endemic area would be the most cost-effective tool to diminish Leishmania burden, an effective vaccine is not yet commercially available. Practically, vaccines have failed to achieve the required level of protection, possibly owing to the lack of an appropriate ...

journal_title：Expert review of vaccines

authors： Doroud D,Rafati S

更新日期：2012-01-01 00:00:00

abstract：:Streptococcus pneumoniae (pneumococcus) is a major cause of worldwide mortality and morbidity, and to a large extent is vaccine-preventable. Nasopharyngeal carriage of pneumococcus precedes disease and is the source of pneumococcal spread between people. The use of vaccine effect on carriage as part of the vaccine lic...

journal_title：Expert review of vaccines

authors： Simell B,Auranen K,Käyhty H,Goldblatt D,Dagan R,O'Brien KL,Pneumococcal Carriage Group.

更新日期：2012-07-01 00:00:00

abstract：:The concept of cancer vaccines is as a therapeutic strategy to immunize the body against cancer antigens that may not be presented by the cancer itself, due to the marked immunosuppressive effects of the disease, which has been demonstrated in many different tumors. ...

journal_title：Expert review of vaccines

authors： Dalgleish AG

更新日期：2004-12-01 00:00:00

abstract：:This section deals with how new knowledge of the development of cellular immunity in the neonatal period informs vaccine development and reviews the immune responses of the most vulnerable group of newborns, those born prematurely, to vaccines. It describes how the development of future vaccine strategies relies on a ...

journal_title：Expert review of vaccines

authors： Prescott S

更新日期：2004-08-01 00:00:00

abstract：:Bordetella pertussis, responsible for one of the oldest vaccine-preventable diseases in children, has resurged in North America, Europe, Latin America and many countries around the world. Despite new recommended vaccination strategies for adolescents, pregnant women and adults, mortality is still significant in develo...

journal_title：Expert review of vaccines

authors： Ulloa-Gutierrez R,Boza R,Carvajal-Riggioni D,Baltodano A

更新日期：2011-01-01 00:00:00

abstract：:In the two decades since their initial discovery, DNA vaccines technologies have come a long way. Unfortunately, when applied to human subjects inadequate immunogenicity is still the biggest challenge for practical DNA vaccine use. Many different strategies have been tested in preclinical models to address this proble...

journal_title：Expert review of vaccines

authors： Li L,Petrovsky N

更新日期：2016-01-01 00:00:00

abstract：:Human papillomavirus (HPV) is widely known as a cause of cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). HPVs related to cancer express two main oncogenes, i.e. E6 and E7, considered as tumorigenic genes; their integration into the host genome results in the abnormal regulation of cell cycle control...

journal_title：Expert review of vaccines

authors： Vici P,Pizzuti L,Mariani L,Zampa G,Santini D,Di Lauro L,Gamucci T,Natoli C,Marchetti P,Barba M,Maugeri-Saccà M,Sergi D,Tomao F,Vizza E,Di Filippo S,Paolini F,Curzio G,Corrado G,Michelotti A,Sanguineti G,Giordano A

更新日期：2016-10-01 00:00:00

abstract：:Dengue virus is the most significant arboviral pathogen worldwide with nearly 400 million infections annually and half the global population at risk of disease. Despite this tremendous public health burden, there are no licensed treatments or vaccines to prevent dengue in humans. Results from clinical trials of leadin...

journal_title：Expert review of vaccines

authors： Widman DG,Baric RS

更新日期：2015-01-01 00:00:00

abstract：:The favorable graft-versus-leukemia (GVL) effect that occurs after stem cell transplantation suggests that T cells can eradicate leukemia blasts. T cells specifically recognize peptides and exert an antileukemia effect. Several leukemia-associated antigens (LAAs) have been found to be overexpressed in malignant cells ...

journal_title：Expert review of vaccines

authors： Casalegno-Garduño R,Schmitt A,Schmitt M

更新日期：2011-06-01 00:00:00

abstract：:Prostate cancer is the second leading cause of cancer-related death among men in the USA. Vaccine strategies represent a novel therapeutic approach. One potential target for a prostate cancer vaccine is prostate-specific antigen, owing to its restricted expression in prostate cancer and normal prostatic epithelial cel...

journal_title：Expert review of vaccines

authors： Madan RA,Gulley JL,Arlen PM

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:Streptococcus pneumoniae causes mucosal and invasive diseases with high morbidity and mortality. Introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) into routine infant immunization programs worldwide resulted in serotype 19A becoming a leading cause of the remaining pneumococcal disease bur...

journal_title：Expert review of vaccines

authors： Isturiz R,Sings HL,Hilton B,Arguedas A,Reinert RR,Jodar L

更新日期：2017-10-01 00:00:00

abstract：:Parallel to attenuated and subunit vaccines, DNA vaccines require adjuvant signals in addition to antigen presentation for the induction of adaptive immune responses. As opposed to common beliefs, increasing evidence is showing that Toll-like receptor 9 activation by CpG motifs present in DNA vaccines are not vital fo...

journal_title：Expert review of vaccines

authors： Tang CK,Pietersz GA

更新日期：2009-09-01 00:00:00

abstract：:Plasmid DNA is a promising vaccine modality that is regularly examined in prime-boost immunization regimens. Recent advances in skin immunity increased our understanding of the sophisticated cutaneous immune network, which revived scientific interest in delivering vaccines to the skin. Intradermal administration of pl...

journal_title：Expert review of vaccines

authors： Elnekave M,Furmanov K,Hovav AH

更新日期：2011-08-01 00:00:00

abstract：:There is growing interest in immunotherapy for malignant gliomas. This interest stems from a number of immunological observations, together with the failure of conventional therapeutic agents to produce broad and clinically meaningful improvements in survival and quality of life. The challenges faced in translating la...

journal_title：Expert review of vaccines

authors： Fenstermaker RA,Ciesielski MJ

更新日期：2014-03-01 00:00:00

abstract：:Immunotherapy is a promising means to fight cancer, prompting a steady increase in clinical trials and correlative laboratory studies in this field. As antitumor T cells play central roles in immunity against malignant diseases, most immunotherapeutic protocols aim to induce and/or strengthen their function. Various t...

journal_title：Expert review of vaccines

authors： Robert-Tissot C,Nguyen LT,Ohashi PS,Speiser DE

更新日期：2013-11-01 00:00:00

abstract：:Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccin...

journal_title：Expert review of vaccines

authors： Kraan H,van der Stel W,Kersten G,Amorij JP

更新日期：2016-08-01 00:00:00

abstract：:Several studies have identified an association between Pandemrix(TM), an AS03 adjuvanted pandemic influenza A(H1N1) vaccine, and narcolepsy, a rare and under-diagnosed sleep disorder with a median onset-to-diagnosis interval of ten years. This paper reviews potential sources of bias in published studies and aims to pr...

journal_title：Expert review of vaccines

authors： Wijnans L,Dodd C,de Ridder M,Romio S,Weibel D,Overeem S,Lammers GJ,Bonhoeffer J,Black S,Sturkenboom M

更新日期：2016-05-01 00:00:00

abstract：:The need for an affordable, safe and effective HIV vaccine has never been greater. As the immunogenicity of all the vaccine vectors being evaluated currently in human populations is limited, novel vaccine strategies are needed to stimulate the innate immune system, to generate high levels of neutralizing antibodies an...

journal_title：Expert review of vaccines

authors： Joseph J,Saubi N,Pezzat E,Gatell JM

更新日期：2006-12-01 00:00:00

abstract：INTRODUCTION:Neisseria meningitidis causes invasive meningococcal disease (IMD), with the highest incidence observed in infants and young children. Meningococcal serogroups A, B, C, W, X, and Y account for almost all IMD cases worldwide. Available meningococcal vaccines targeting serogroups A, C, W, and Y (MenACWY) inc...

journal_title：Expert review of vaccines

authors： Martinón-Torres F,Serra L,Safadi MAP

更新日期：2020-04-01 00:00:00