Abstract:
:Human papillomavirus (HPV) is widely known as a cause of cervical cancer (CC) and cervical intraepithelial neoplasia (CIN). HPVs related to cancer express two main oncogenes, i.e. E6 and E7, considered as tumorigenic genes; their integration into the host genome results in the abnormal regulation of cell cycle control. Due to their peculiarities, these oncogenes represent an excellent target for cancer immunotherapy. In this work the authors highlight the potential use of therapeutic vaccines as safe and effective pharmacological tools in cervical disease, focusing on vaccines that have reached the clinical trial phase. Many therapeutic HPV vaccines have been tested in clinical trials with promising results. Adoptive T-cell therapy showed clinical activity in a phase II trial involving advanced CC patients. A phase II randomized trial showed clinical activity of a nucleic acid-based vaccine in HPV16 or HPV18 positive CIN. Several trials involving peptide-protein-based vaccines and live-vector based vaccines demonstrated that these approaches are effective in CIN as well as in advanced CC patients. HPV therapeutic vaccines must be regarded as a therapeutic option in cervical disease. The synergic combination of HPV therapeutic vaccines with radiotherapy, chemotherapy, immunomodulators or immune checkpoint inhibitors opens a new and interesting scenario in this disease.
journal_name
Expert Rev Vaccinesjournal_title
Expert review of vaccinesauthors
Vici P,Pizzuti L,Mariani L,Zampa G,Santini D,Di Lauro L,Gamucci T,Natoli C,Marchetti P,Barba M,Maugeri-Saccà M,Sergi D,Tomao F,Vizza E,Di Filippo S,Paolini F,Curzio G,Corrado G,Michelotti A,Sanguineti G,Giordano Adoi
10.1080/14760584.2016.1176533subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1327-36issue
10eissn
1476-0584issn
1744-8395journal_volume
15pub_type
杂志文章,评审abstract::Active immunotherapy aimed at the stimulation of tumor-specific T cells has established itself within the clinic as a therapeutic option to treat cancer. One strategy is the use of so-called peptides that mimic genuine T-cell epitopes as vaccines to activate tumor-specific T cells. In various clinical trials, differen...
journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
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journal_title:Expert review of vaccines
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Expert review of vaccines
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Expert review of vaccines
pub_type: 杂志文章,评审
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pub_type: 传,历史文章,面试
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更新日期:2013-10-01 00:00:00
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