Abstract：
:Here we present a study on the impact of assumptions on image-based hemodynamic simulations of healthy carotid bifurcations. In particular, we evaluate to which extent assumptions on blood rheology influence bulk flow features, driven by the fact that few studies have provided adequate insights into the influence of assumptions to confidently model the 4D hemodynamics within the bifurcation. The final goal is to complement, integrate and extend with a quantitative characterization of the bulk flow the description currently adopted to classify altered hemodynamics, which is based on wall shear stress (WSS). Hemodynamic simulations of two image-based carotid bifurcation geometries were carried out assuming a reference Newtonian viscosity, two non-Newtonian rheology models and Newtonian viscosities based on characteristic shear rates. WSS-based and Lagrangian-based metrics for helical flow quantification and for vorticity dynamics quantification were calculated. Our findings suggest that the assumption of Newtonian rheology: (1) could be reasonable for bulk flow metrics (differences from non-Newtonian behavior are lower than 10%); (2) influences at different levels the WSS-based indicators, depending on the bifurcation model, even if in our study it is lower than the major source of uncertainty as recognized by the literature (i.e., uncertainty on geometry reconstruction).
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Morbiducci U,Gallo D,Massai D,Ponzini R,Deriu MA,Antiga L,Redaelli A,Montevecchi FMdoi
10.1016/j.jbiomech.2011.06.028subject
Has Abstractpub_date
2011-09-02 00:00:00pages
2427-38issue
13eissn
0021-9290issn
1873-2380pii
S0021-9290(11)00478-7journal_volume
44pub_type
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