Abstract:
:Creep is a time-dependent viscoelastic deformation observed under a constant prolonged load. It has been indicated that progressive vertebral deformation due to creep may increase the risk of vertebral fracture in the long-term. The objective of this study was to examine the relationships of creep with trabecular architecture and tissue mineral density (TMD) parameters in human vertebral cancellous bone at a physiological static strain level. Architecture and TMD parameters of cancellous bone were analyzed using microcomputerized tomography (micro-CT) in specimens cored out of human vertebrae. Then, creep and residual strains of the specimens were measured after a two-hour physiological compressive constant static loading and unloading cycle. Creep developed (3877 ± 2158 με) resulting in substantial levels of non-recoverable post-creep residual strain (1797 ± 1391 με). A strong positive linear correlation was found between creep and residual strain (r = 0.94, p < 0.001). The current results showed that smaller thickness, larger surface area, greater connectivity of trabeculae, less mean tissue mineral density (TMD, represented by gray levels) and higher variability of TMD are associated with increasing logarithmic creep rate. The TMD variability (GL(COV)) was the strongest correlate of creep rate (r = 0.79, p < 0.001). This result suggests that TMD variability may be a useful parameter for estimating the long-term deformation of a whole vertebral body. The results further suggest that the changes in TMD variability resulting from bone remodeling are of importance and may provide an insight into the understanding of the mechanisms underlying progressive failure of vertebral bodies and development of a clinical fracture.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Kim DG,Shertok D,Ching Tee B,Yeni YNdoi
10.1016/j.jbiomech.2011.03.025subject
Has Abstractpub_date
2011-06-03 00:00:00pages
1660-5issue
9eissn
0021-9290issn
1873-2380pii
S0021-9290(11)00278-8journal_volume
44pub_type
杂志文章abstract::The successful development of early-stage cartilage and meniscus repair interventions in the knee requires biomechanical and biotribological understanding of the design of the therapeutic interventions and their tribological function in the natural joint. The aim of this study was to develop and validate a porcine kne...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.07.043
更新日期:2015-09-18 00:00:00
abstract::Bone remodelling is a dynamic process that requires the coordinated interaction of osteocytes, osteoblasts, and osteoclasts, collaborating in basic multicellular units (BMUs). Communication between these cells can be by extracellular soluble molecules as well as directly propagating intercellular signalling molecules....
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2007.02.015
更新日期:2007-01-01 00:00:00
abstract::The gait cycle is usually analyzed using one of two conventions: heel contact initiates the cycle and stance is followed by swing phases or toe-off initiates the cycle and swing then stance phases are analyzed. The purpose of the study is to demonstrate that based on a consideration of relevant biomechanical measures,...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(94)90025-6
更新日期:1994-04-01 00:00:00
abstract::Tendon elasticity is important for economical locomotion; however it is unknown whether tendon stiffness is appropriate to achieve an optimal efficiency in various muscles. Here we test the hypothesis that the Achilles tendon is of an appropriate stiffness to maximise medial gastrocnemius muscle efficiency during loco...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2006.07.025
更新日期:2007-01-01 00:00:00
abstract::Although biomechanical studies of the normal rat vein wall have been reported (Weizsacker, 1988; Plante, 2002), there are no published studies that have investigated the mechanical effects of thrombus formation on murine venous tissue. In response to the lack of knowledge concerning the mechanical consequences of thro...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.07.012
更新日期:2010-11-16 00:00:00
abstract::Recent first attempts of in situ ultrasound strain imaging in collateral ligaments encountered a number of challenges and illustrated a clear need for additional studies and more thorough validation of the available strain imaging methods. Therefore, in this study we experimentally validated ultrasound strain measurem...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.03.035
更新日期:2018-05-17 00:00:00
abstract::Failure of synthetic heart valves is usually caused by tearing and calcification of the leaflets. Leaflet fiber-reinforcement increases the durability of these valves by unloading the delicate parts of the leaflets, maintaining their physiological functioning. The interaction of the valve with the surrounding fluid is...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(00)00068-3
更新日期:2000-09-01 00:00:00
abstract::Orthopaedic management of femoral head osteonecrosis is a common clinical problem for which there presently is no good solution. Current animal models are inappropriate to study potential new solutions, since it has been difficult to replicate the natural history of structural collapse seen in the human disorder. Rece...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(03)00154-4
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Children with spastic cerebral palsy (CP) experience secondary musculoskeletal adaptations, affecting the mechanical and material properties of muscles and tendons. CP-related changes in the spastic muscle are well documented whilst less is known about the tendon. From a clinical perspective, it is important...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.07.020
更新日期:2016-09-06 00:00:00
abstract::Evaluation of workers' body posture in workstations is a prerequisite to estimate spinal loads and assess risk of injury for the subsequent design of preventive interventions. The Microsoft Kinect™ sensor is, in this regard, advantageous over the traditional skin-marker-based optical motion capture systems for being m...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.110043
更新日期:2020-11-09 00:00:00
abstract::Glaucoma is a common cause of blindness. Studies of this disease can involve collection of aqueous humor (AH) fluid from eyes of patients undergoing surgery, which involves aspirating a small fluid volume from the anterior region of the eye through a fine-bore needle. Unfortunately, the composition of the AH is spatia...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.07.025
更新日期:2009-11-13 00:00:00
abstract::Locomotion involves complex neural networks responsible for automatic and volitional actions. During locomotion, motor strategies can rapidly compensate for any obstruction or perturbation that could interfere with forward progression. In this pilot study, we examined the contribution of interlimb pathways for evoking...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.04.042
更新日期:2015-08-20 00:00:00
abstract::This paper deals with the impact force during foot-ground impact activities such as the running. A previously developed model is used for this study. The model is a lumped-parameter one consisting of four masses connected to each other via linear springs and viscous dampers. A shoe-specific nonlinear function is used ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2006.09.016
更新日期:2007-01-01 00:00:00
abstract::Previous models to predict breast movement whilst performing physical activities have, erroneously, assumed uniform elasticity within the breast. Consequently, the predicted displacements have not yet been satisfactorily validated. In this study, real time motion capture of the natural vibrations of a breast that foll...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.11.027
更新日期:2018-01-23 00:00:00
abstract::The elastic modulus of bioengineered materials has a strong influence on the phenotype of many cells including cardiomyocytes. On polyacrylamide (PAA) gels that are laminated with ligands for integrins, cardiac myocytes develop well organized sarcomeres only when cultured on substrates with elastic moduli in the range...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.11.023
更新日期:2012-03-15 00:00:00
abstract::Previous epidemiological studies indicate that the use of thumb-push mechanical pipettes is associated with musculoskeletal disorders (MSDs) in the hand. The goal of the current study was to analyze the loading in the muscle-tendon units in the thumb during pipetting. The hand is modeled as a multi-body linkage system...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.11.015
更新日期:2014-01-22 00:00:00
abstract::This paper presents a new direct method for estimating the average center of rotation (CoR). An existing least-squares (LS) solution has been shown by previous works to have reduced accuracy for data with small range of motion (RoM). Alternative methods proposed to improve the CoR estimation use iterative algorithms. ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2006.05.010
更新日期:2007-01-01 00:00:00
abstract::Non-invasive estimation of arterial blood volume flow (BVF) has become a central issue in assessment of cardiovascular risk. Poiseuille and Womersley approaches are commonly used to assess the BVF from centerline velocity, but both methods neglect the influence of curvature. Based on the assumption that the velocity i...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.04.032
更新日期:2009-08-07 00:00:00
abstract::People with a transtibial amputation have numerous secondary health conditions, including an increased prevalence of low back pain. This increased prevalence may be partially explained by altered low back biomechanics during movement. The purpose of this study was to compare trunk kinematics and L4-L5 lumbar loads in ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.12.030
更新日期:2018-03-01 00:00:00
abstract::A new transducer was developed for in situ measurement of the force vector in a complex muscle. The transducer measures the magnitude, and the line of action of a force in a single plane. The dynamic range of the transducer is 0-5 N. This range includes the small forces developed by an active motor unit and the relati...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(96)84545-3
更新日期:1996-11-01 00:00:00
abstract::The negative charges on proteoglycans significantly affect the mechanical behaviors of articular cartilage. Mixture theories, such as the triphasic theory, can describe quantitatively how this charged nature contributes to the mechano-electrochemical behaviors of such tissue. However, the mathematical complexity of th...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.10.026
更新日期:2010-03-03 00:00:00
abstract::Patterns in cell adhesion molecule expression by endothelial cells may play a role in atherogenesis. Previous studies have shown dependence of intracellular adhesion molecule-1 (ICAM-1) expression in human umbilical vein endothelial cells (HUVEC) on shear stress and have indirectly linked ICAM-1 expression to spatial ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2005.02.002
更新日期:2006-01-01 00:00:00
abstract::The goal of the present study was to assess the effects of age and sex on trunk motor control. Fifty healthy adults (aged between 19 and 67 years, 28 males) participated in this study. Trunk motor control was assessed using force-controlled perturbations directly applied to the trunk. Admittance (inverse of lumped int...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109607
更新日期:2020-03-26 00:00:00
abstract::To test the hypothesis that stress deprivation induces over-expression of cytokines in the patellar tendon, 40 rats were divided into the following two groups. In the stress-shielded group, we slackened the patellar tendon in the right knee by drawing the patella toward the tibial tubercle with flexible wires. In the ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.05.009
更新日期:2005-04-01 00:00:00
abstract::Intravesical and urethral pressure signals during cough and Valsalva maneuvers for 15 continent women were analyzed with frequency spectrum analysis. Clear modulation of the urethral pressure changes by the intravesical pressure rise during stress maneuvers was demonstrated in the frequency bands of 14 and 7 Hz for co...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(01)00006-9
更新日期:2001-05-01 00:00:00
abstract::As a first step towards developing a dynamic model of the rat hindlimb, we measured muscle attachment and joint center coordinates relative to bony landmarks using stereophotogrammetry. Using these measurements, we analyzed muscle moment arms as functions of joint angle for most hindlimb muscles, and tested the hypoth...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2007.10.004
更新日期:2008-01-01 00:00:00
abstract::The motor module hypothesis in motor control proposes that the nervous system can simplify the problem of controlling a large number of muscles in human movement by grouping muscles into a smaller number of modules. Here, we tested one prediction of the modular organization hypothesis by examining whether there is pre...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.02.006
更新日期:2016-03-21 00:00:00
abstract::Vortex shedding at vascular anastomoses were investigated in vitro using a 20 MHz pulsed-wave Doppler velocimeter. Centreline velocity measurements were made at various axial distances in simplified polyurethane models of proximal and distal end-to-side anastomoses of angles 15, 30, 45, 60 and 80 degrees using pulsati...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(99)00056-1
更新日期:1999-07-01 00:00:00
abstract::The nanomechanical properties of individual cartilage cells (chondrocytes) and their aggrecan and collagen-rich pericellular matrix (PCM) were measured via atomic force microscope nanoindentation using probe tips of two length scales (nanosized and micron-sized). The properties of cells freshly isolated from cartilage...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2006.04.004
更新日期:2007-01-01 00:00:00
abstract::Because the hand is a complex poly-articular limb, numerous methods have been proposed to investigate its kinematics therefore complicating the comparison between studies and the methodological choices. With the objective of overcoming such issues, the present study compared the effect of three local frame definitions...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.05.025
更新日期:2014-08-22 00:00:00