当前位置： SCI文献检索 > JOURNAL OF BIOMECHANICS期刊下所有文献 > Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors.

Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors.

Abstract：

:The elastic modulus of bioengineered materials has a strong influence on the phenotype of many cells including cardiomyocytes. On polyacrylamide (PAA) gels that are laminated with ligands for integrins, cardiac myocytes develop well organized sarcomeres only when cultured on substrates with elastic moduli in the range 10 kPa-30 kPa, near those of the healthy tissue. On stiffer substrates (>60 kPa) approximating the damaged heart, myocytes form stress fiber-like filament bundles but lack organized sarcomeres or an elongated shape. On soft (<1 kPa) PAA gels myocytes exhibit disorganized actin networks and sarcomeres. However, when the polyacrylamide matrix is replaced by hyaluronic acid (HA) as the gel network to which integrin ligands are attached, robust development of functional neonatal rat ventricular myocytes occurs on gels with elastic moduli of 200 Pa, a stiffness far below that of the neonatal heart and on which myocytes would be amorphous and dysfunctional when cultured on polyacrylamide-based gels. The HA matrix by itself is not adhesive for myocytes, and the myocyte phenotype depends on the type of integrin ligand that is incorporated within the HA gel, with fibronectin, gelatin, or fibrinogen being more effective than collagen I. These results show that HA alters the integrin-dependent stiffness response of cells in vitro and suggests that expression of HA within the extracellular matrix (ECM) in vivo might similarly alter the response of cells that bind the ECM through integrins. The integration of HA with integrin-specific ECM signaling proteins provides a rationale for engineering a new class of soft hybrid hydrogels that can be used in therapeutic strategies to reverse the remodeling of the injured myocardium.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Chopra A,Lin V,McCollough A,Atzet S,Prestwich GD,Wechsler AS,Murray ME,Oake SA,Kresh JY,Janmey PA

doi

10.1016/j.jbiomech.2011.11.023

subject

Has Abstract

pub_date

2012-03-15 00:00:00

pages

824-31

issue

5

eissn

0021-9290

issn

1873-2380

pii

S0021-9290(11)00705-6

journal_volume

45

pub_type

杂志文章

相关文献

JOURNAL OF BIOMECHANICS文献大全
  • In vivo measurement of ACL length and relative strain during walking.

    abstract：:Although numerous studies have addressed the effects of ACL injury and reconstruction on knee joint motion, there is currently little data available describing in vivo ACL strain during activities of daily living. Data describing in vivo ACL strain during activities such as gait is critical to understanding the biomec...

    journal_title：Journal of biomechanics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jbiomech.2012.10.031

    authors： Taylor KA,Cutcliffe HC,Queen RM,Utturkar GM,Spritzer CE,Garrett WE,DeFrate LE

    更新日期：2013-02-01 00:00:00

  • Compressive properties of cd-HA-gelatin modified intrasynovial tendon allograft in canine model in vivo.

    abstract：:Although we sometimes use the intrasynovial tendon allograft as a donor, the gliding ability of allograft prepared by lyophilization is significantly decreased. The gliding ability of the grafted tendon after tendon reconstruction is very important because the high gliding resistance causes more adhesion and leads to ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2010.12.030

    authors： Ikeda J,Zhao C,Chen Q,Thoreson AR,An KN,Amadio PC

    更新日期：2011-06-03 00:00:00

  • Factors influencing performance in the Hecht vault and implications for modelling.

    abstract：:This paper investigated the factors that influence Hecht vault performance and assessed the level of model complexity required to give an adequate representation of vaulting. A five-segment planar simulation model with a visco-elastic shoulder joint and a torque generator at the shoulder joint was used to simulate the...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2004.02.039

    authors： King MA,Yeadon MR

    更新日期：2005-01-01 00:00:00

  • Fracture properties of bovine tibial bone.

    abstract：:Linear elastic fracture mechanics predicts that the fracture stress of precracked materials is dependent on the length of the initial crack tip radius of curvature, as supported by the Griffith and Inglis equations. In order to determine the applicability of these equations and the effects of other variables, tensile ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(86)90187-9

    authors： Moyle DD,Gavens AJ

    更新日期：1986-01-01 00:00:00

  • Numerical exploration of the combined effect of nutrient supply, tissue condition and deformation in the intervertebral disc.

    abstract：:Novel strategies to heal discogenic low back pain could highly benefit from comprehensive biophysical studies that consider both mechanical and biological factors involved in intervertebral disc degeneration. A decrease in nutrient availability at the bone-disc interface has been indicated as a relevant risk factor an...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2014.02.004

    authors： Malandrino A,Noailly J,Lacroix D

    更新日期：2014-04-11 00:00:00

  • Interlimb coordination in body-weight supported locomotion: A pilot study.

    abstract：:Locomotion involves complex neural networks responsible for automatic and volitional actions. During locomotion, motor strategies can rapidly compensate for any obstruction or perturbation that could interfere with forward progression. In this pilot study, we examined the contribution of interlimb pathways for evoking...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.04.042

    authors： Seiterle S,Susko T,Artemiadis PK,Riener R,Igo Krebs H

    更新日期：2015-08-20 00:00:00

  • Random field assessment of inhomogeneous bone mineral density from DXA scans can enhance the differentiation between postmenopausal women with and without hip fractures.

    abstract：:Bone mineral density (BMD) measurements from Dual-energy X-ray Absorptiometry (DXA) alone cannot account for all factors associated with the risk of hip fractures. For example, the inhomogeneity of bone mineral density in the hip region also contributes to bone strength. In the stochastic assessment of bone inhomogene...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.01.030

    authors： Dong XN,Pinninti R,Lowe T,Cussen P,Ballard JE,Di Paolo D,Shirvaikar M

    更新日期：2015-04-13 00:00:00

  • Comparison of marker models for the analysis of the volume variation and thoracoabdominal motion pattern in untrained and trained participants.

    abstract：:Respiratory assessment and the biomechanical analysis of chest and abdomen motion during breathing can be carried out using motion capture systems. An advantage of this methodology is that it allows analysis of compartmental breathing volumes, thoraco-abdominal patterns, percentage contribution of each compartment and...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2018.05.036

    authors： Massaroni C,Piaia Silvatti A,Levai IK,Dickinson J,Winter S,Schena E,Silvestri S

    更新日期：2018-07-25 00:00:00

  • In vivo human knee joint dynamic properties as functions of muscle contraction and joint position.

    abstract：:Information on the dynamic properties (joint stiffness, viscosity and limb inertia) of the human knee joint is scarce in the literature, especially for actively contracting knee musculature. A joint driving device was developed to apply small-amplitude random perturbations to the human knee at several flexion angles w...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(97)00106-1

    authors： Zhang LQ,Nuber G,Butler J,Bowen M,Rymer WZ

    更新日期：1998-01-01 00:00:00

  • Vertebroplasty reduces progressive ׳creep' deformity of fractured vertebrae.

    abstract：:Elderly vertebrae frequently develop an "anterior wedge" deformity as a result of fracture and creep mechanisms. Injecting cement into a damaged vertebral body (vertebroplasty) is known to help restore its shape and stiffness. We now hypothesise that vertebroplasty is also effective in reducing subsequent creep deform...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.09.006

    authors： Luo J,Pollintine P,Annesley-Williams DJ,Dolan P,Adams MA

    更新日期：2016-04-11 00:00:00

  • Alternative measures of toe trajectory more accurately predict the probability of tripping than minimum toe clearance.

    abstract：:Tripping is responsible for a large percentage of falls. Minimum toe clearance (MTC) during the swing phase of gait is commonly used to infer the probability of tripping (POT). However, there is limited empirical evidence to support the relationship between these two variables, and other measures of toe trajectory may...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.10.045

    authors： Byju AG,Nussbaum MA,Madigan ML

    更新日期：2016-12-08 00:00:00

  • The effect on patellofemoral joint stability of selective cutting of lateral retinacular and capsular structures.

    abstract：:Patient selection for lateral retinacular release (LRR) and its efficacy are controversial. Iatrogenic medial subluxation can occur with inappropriate LRR. The aim of this study was to determine the reduction in patellofemoral stability with progressively more extensive LRR. The force required to displace the patella ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2008.11.003

    authors： Merican AM,Kondo E,Amis AA

    更新日期：2009-02-09 00:00:00

  • Non-Newtonian blood flow in human right coronary arteries: steady state simulations.

    abstract：:This study looks at blood flow through four different right coronary arteries, which have been reconstructed from bi-plane angiograms. Five non-Newtonian blood models, as well as the usual Newtonian model of blood viscosity, are used to study the wall shear stress in each of these arteries at a particular point in the...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2003.09.016

    authors： Johnston BM,Johnston PR,Corney S,Kilpatrick D

    更新日期：2004-05-01 00:00:00

  • 3D Imaging of vascular networks for biophysical modeling of perfusion distribution within the heart.

    abstract：:One of the main determinants of perfusion distribution within an organ is the structure of its vascular network. Past studies were based on angiography or corrosion casting and lacked quantitative three dimensional, 3D, representation. Based on branching rules and other properties derived from such imaging, 3D vascula...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbiomech.2012.11.027

    authors： van den Wijngaard JP,Schwarz JC,van Horssen P,van Lier MG,Dobbe JG,Spaan JA,Siebes M

    更新日期：2013-01-18 00:00:00

  • Hemodynamic insight into overlapping bare-metal stents strategy in the treatment of aortic aneurysm.

    abstract：:Clinical trials have shown overlapping bare-metal stents provoke effective thrombus clot within the aneurysm sac and shrinkage of the aneurysm by directly regulating the hemodynamics. To gain insight into the hemodynamic mechanism of the technique, three cases of simplified thoracic aortic aneurysm models (with no ste...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.03.028

    authors： Zhang P,Liu X,Sun A,Fan Y,Deng X

    更新日期：2015-07-16 00:00:00

  • Digital volume correlation and micro-CT: An in-vitro technique for measuring full-field interface micromotion around polyethylene implants.

    abstract：:Micromotion around implants is commonly measured using displacement-sensor techniques. Due to the limitations of these techniques, an alternative approach (DVC-μCT) using digital volume correlation (DVC) and micro-CT (μCT) was developed in this study. The validation consisted of evaluating DVC-μCT based micromotion ag...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2015.05.024

    authors： Sukjamsri C,Geraldes DM,Gregory T,Ahmed F,Hollis D,Schenk S,Amis A,Emery R,Hansen U

    更新日期：2015-09-18 00:00:00

  • A new transducer system for direct motor unit force measurement.

    abstract：:A new transducer was developed for in situ measurement of the force vector in a complex muscle. The transducer measures the magnitude, and the line of action of a force in a single plane. The dynamic range of the transducer is 0-5 N. This range includes the small forces developed by an active motor unit and the relati...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(96)84545-3

    authors： Turkawski SJ,van Ruijven LJ,van Kuyen M,Schreurs AW,Weijs WA

    更新日期：1996-11-01 00:00:00

  • Reducing upper airway collapse at lower continuous positive airway titration pressure.

    abstract：:During respiration, upper airway (UA) collapse occurs when the forces generated from the negative UA pressures exceed the forces produced by the UA muscles; which leads to loose soft tissue at the back of the mouth. At predetermined titration pressure, the Continuous Positive Airway Pressure (CPAP) normally provides a...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.11.005

    authors： Ashaat S,Al-Jumaily AM

    更新日期：2016-12-08 00:00:00

  • Influences of spherical tip radius, contact depth, and contact area on nanoindentation properties of bone.

    abstract：:Nanoindentation has been widely used as a means to measure the micro-mechanical properties of bone and to predict the macroscopic properties. The role of indent depth and indenter tip geometry in measuring the hierarchical properties of bone tissue was explored experimentally using a range of spherical indenter tips o...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2010.10.008

    authors： Paietta RC,Campbell SE,Ferguson VL

    更新日期：2011-01-11 00:00:00

  • Residual strength of equine bone is not reduced by intense fatigue loading: implications for stress fracture.

    abstract：:Fatigue or stress fractures are an important clinical problem in humans as well as racehorses. An important question in this context is, when a bone experiences fatigue damage during extreme use, how much is it weakened compared to its original state? Since there are very limited data on this question and stress fract...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(96)00113-3

    authors： Martin RB,Gibson VA,Stover SM,Gibeling JC,Griffin LV

    更新日期：1997-02-01 00:00:00

  • Shank and rearfoot coordination and its variability during running in flatfoot.

    abstract：:Flatfoot is a risk factor for patellofemoral pain syndrome (PFPS), and excessive rearfoot eversion occurring in flatfoot has been associated with the development and progression of PFPS; however, the mechanism remains unclear. This study aimed to investigate transverse shank and frontal rearfoot coordination patterns ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2020.110119

    authors： Takabayashi T,Edama M,Inai T,Kubo M

    更新日期：2021-01-22 00:00:00

  • Chaos in the discrete-time algorithm for bone-density remodeling rate equations.

    abstract：:We compare the predictions of the differential equation form of a class of bone-density stress adaptation models with their associated discrete-time computational algorithms. Although our considerations apply to the class of adaptation models based on bulk or apparent bone-density remodeling, we focus attention on a p...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(05)80007-7

    authors： Cowin SC,Arramon YP,Luo GM,Sadegh AM

    更新日期：1993-09-01 00:00:00

  • Comparison of blood particle deposition models for non-parallel flow domains.

    abstract：:Adhesions of monocytes and platelets to a vascular surface, particularly in regions of flow stagnation, recirculation, and reattachment, are a significant initial event in a broad spectrum of particle-wall interactions that significantly influence the formation of stenotic lesions and mural thrombi. A number of approx...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(02)00434-7

    authors： Worth Longest P,Kleinstreuer C

    更新日期：2003-03-01 00:00:00

  • Mechanical characterisation of porcine rectus sheath under uniaxial and biaxial tension.

    abstract：:Incisional hernia development is a significant complication after laparoscopic abdominal surgery. Intra-abdominal pressure (IAP) is known to initiate the extrusion of intestines through the abdominal wall, but there is limited data on the mechanics of IAP generation and the structural properties of rectus sheath. This...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2014.03.009

    authors： Lyons M,Winter DC,Simms CK

    更新日期：2014-06-03 00:00:00

  • Using regression models to determine the poroelastic properties of cartilage.

    abstract：:The feasibility of determining biphasic material properties using regression models was investigated. A transversely isotropic poroelastic finite element model of stress relaxation was developed and validated against known results. This model was then used to simulate load intensity for a wide range of material proper...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2013.05.028

    authors： Chung CY,Mansour JM

    更新日期：2013-07-26 00:00:00

  • Hydro-resistive measurement of dynamic lifting strength.

    abstract：:A device is described for measuring strength and power outputs of dynamic vertical lifts between heights of 0.4 and 2.2 m. The device is safe, robust, and easily transportable. It consists of a water-filled tube 2 m high and 200 mm internal diameter. The subject pulls vertically on a handle which is connected with fle...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/s0021-9290(96)00155-8

    authors： Pinder AD,Grieve DW

    更新日期：1997-04-01 00:00:00

  • A kinematic and strain gauge study of the reciprocal apparatus in the equine hind limb.

    abstract：:Hind limb kinematics were recorded in five horses at walk and trot using an opto-electronic CODA-3 system. Simultaneously, in vivo strain in the completely tendinous peroneus tertius muscle was registered by implanted mercury-in-silastic strain gauges. The origin-insertion length patterns of the peroneus tertius were ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/0021-9290(92)90284-8

    authors： van Weeren PR,Jansen MO,van den Bogert AJ,Barneveld A

    更新日期：1992-11-01 00:00:00

  • The range of axial rotation of the glenohumeral joint.

    abstract：:There is a paucity of data in the literature on the restraining effects of the glenohumeral (GH) ligaments; cadaveric testing is one of the best methods for determining the function of these types of tissues. The aim of this work was to commission a custom-made six degrees of freedom (dof) joint loading apparatus and ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2009.03.007

    authors： Southgate DF,Hill AM,Alexander S,Wallace AL,Hansen UN,Bull AM

    更新日期：2009-06-19 00:00:00

  • Separating brain motion into rigid body displacement and deformation under low-severity impacts.

    abstract：:The relative motion of the brain with respect to the skull has been widely studied to investigate brain injury mechanisms under impacts, but the motion patterns are not yet thoroughly understood. This work analyzes brain motion patterns using the most recent and advanced experimental relative brain/skull motion data c...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章,评审

    doi：10.1016/j.jbiomech.2006.06.018

    authors： Zou H,Schmiedeler JP,Hardy WN

    更新日期：2007-01-01 00:00:00

  • Modeling the mechanical properties of liver fibrosis in rats.

    abstract：:The progression of liver fibrosis changes the biomechanical properties of liver tissue. This study characterized and compared different liver fibrosis stages in rats in terms of viscoelasticity. Three viscoelastic models, the Voigt, Maxwell, and Zener models, were applied to experimental data from rheometer tests and ...

    journal_title：Journal of biomechanics

    pub_type： 杂志文章

    doi：10.1016/j.jbiomech.2016.03.013

    authors： Zhu Y,Chen X,Zhang X,Chen S,Shen Y,Song L

    更新日期：2016-06-14 00:00:00