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Modeling the mechanical properties of liver fibrosis in rats.

Abstract：

:The progression of liver fibrosis changes the biomechanical properties of liver tissue. This study characterized and compared different liver fibrosis stages in rats in terms of viscoelasticity. Three viscoelastic models, the Voigt, Maxwell, and Zener models, were applied to experimental data from rheometer tests and then the elasticity and viscosity were estimated for each fibrosis stage. The study found that both elasticity and viscosity are correlated with the various stages of liver fibrosis. The study revealed that the Zener model is the optimal model for describing the mechanical properties of each fibrosis stage, but there is no significant difference between the Zener and Voigt models in their performance on liver fibrosis staging. Therefore the Voigt model can still be effectively used for liver fibrosis grading.

journal_name

J Biomech

journal_title

Journal of biomechanics

authors

Zhu Y,Chen X,Zhang X,Chen S,Shen Y,Song L

doi

10.1016/j.jbiomech.2016.03.013

subject

Has Abstract

pub_date

2016-06-14 00:00:00

pages

1461-1467

issue

9

eissn

0021-9290

issn

1873-2380

pii

S0021-9290(16)30296-2

journal_volume

49

pub_type

杂志文章

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