Abstract：
:Resident cells in the surface epitenon and internal compartment of flexor tendons are subjected to cyclic mechanical load as muscle contracts to move limbs or digits. Tendons are largely tensile load bearing tissues and are highly matrix intensive with nondividing cells providing maintenance functions. However, when an injury occurs, tendon cells are stimulated to divide by activated endogenous growth factors and those from platelets and plasma. We hypothesize that tendon cells detect mechanical load signals but do not interpret such signals as mitogenic unless an active growth factor is present. We have used an in vitro mechanical load model, application of cyclic strain to cells cultured on flexible bottomed culture plates, to test the hypothesis that tendon cells require platelet-derived growth factor (PDGF-BB) and insulin-like growth factor-I (IGF-I) in addition to mechanical load to stimulate DNA synthesis. In addition, we demonstrate that in avian tendon cells, load and growth factors stimulate phosphorylation of tyrosine residues in multiple proteins, including pp60src, a protein kinase that phosphorylates receptor protein tyrosine kinases. A lack of mitogenic responsiveness to mechanical load alone by tendon cells may be a characteristic of a regulatory pathway that modulates cell division.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Banes AJ,Tsuzaki M,Hu P,Brigman B,Brown T,Almekinders L,Lawrence WT,Fischer Tdoi
10.1016/0021-9290(95)00098-4subject
Has Abstractpub_date
1995-12-01 00:00:00pages
1505-13issue
12eissn
0021-9290issn
1873-2380pii
0021-9290(95)00098-4journal_volume
28pub_type
杂志文章abstract：:A continuous wave technique is described for measuring the nine independent orthotropic elastic coefficients from a single cubic specimen. The side dimensions of this cubic specimen are on the order of 5 mm. Because of the small size of the specimen, the spatial resolution of material inhomogeneity using this techniqu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Journal of biomechanics
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.06.011
更新日期：2016-09-06 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.12.012
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pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：2017-08-16 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：2015-08-20 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.08.027
更新日期：2006-01-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(99)00054-8
更新日期：1999-07-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2015-11-05 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1996-04-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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