Abstract：
:Adhesions of monocytes and platelets to a vascular surface, particularly in regions of flow stagnation, recirculation, and reattachment, are a significant initial event in a broad spectrum of particle-wall interactions that significantly influence the formation of stenotic lesions and mural thrombi. A number of approximations are available for the simulation of both monocyte and platelet interactions with the vascular surface. For the simulation of blood particle adhesion, this study hypothesizes that: (a) the discrete element approach, which accounts for finite particle size and inertia, is advantageous in the context of non-parallel flow domains including stagnation, recirculation, and reattachment; and (b) the likelihood for particle deposition may be effectively approximated as being non-linearly proportional to local particle concentration, residence time, and wall proximity. Models such as wall shear stress correlations, the multicomponent mixture approach, and Lagrangian particle tracking with and without hydrodynamic particle-wall interactions were evaluated. Quantitative performance of the selected models was established by comparisons to available experimental data sets for non-parallel axisymmetric suspension flows of monocytes and platelets. Factors including the convective-diffusive transport of particles, finite particle size and inertia, as well as near-wall hydrodynamic interactions were found to significantly influence blood particle deposition. Of the models studied, the near-wall residence time approach was found to be a particularly effective indicator for the deposition of monocytes (r2=0.74) and platelets (r2=0.57), given that nano-scale physical and biochemical effects must be greatly approximated in computational simulations involving relatively large-scale geometries and complex flow fields.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Worth Longest P,Kleinstreuer Cdoi
10.1016/s0021-9290(02)00434-7keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
421-30issue
3eissn
0021-9290issn
1873-2380pii
S0021929002004347journal_volume
36pub_type
杂志文章abstract：:Mechanical properties of abdominal and thoracic arteries of 2mm in diameter were determined from adults Wistar rats. A tensile testing instrument was used to obtain stress/strain curves with arteries immersed in physiological buffer at 37 degrees C. A displacement was applied on all arteries with various frequencies (...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.04.017
更新日期：2008-07-19 00:00:00
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：1994-12-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.03.026
更新日期：2014-06-03 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(94)90025-6
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.11.050
更新日期：2014-02-07 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.110085
更新日期：2020-12-02 00:00:00
abstract：:The biomechanical characteristics of bone tissue and its cells under mechanical stress are significant for bone biomechanics research, but the mechanism of mechanotransduction is still unknown. It has been established that the actin cytoskeleton of osteoblasts plays an important role in this process. However, the stru...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.08.010
更新日期：2008-11-14 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.12.014
更新日期：2014-03-21 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.02.007
更新日期：2018-04-11 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.04.025
更新日期：2013-07-26 00:00:00
abstract：:The objective of this study was to examine the use of the continuous wavelet transform (CWT) on surface electromyographic (sEMG) signals acquired from the lower extremity muscles during gait in children with typical development (TD) and cerebral palsy (CP). This was done to explore the possibility of developing a quan...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2004.07.002
更新日期：2005-06-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2013.07.039
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(92)90271-2
更新日期：1992-02-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.06.031
更新日期：2012-09-21 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(95)80005-0
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:OpenSim models are typically based on cadaver findings that are generalized to represent a wide range of populations, which curbs their validity. Patient-specific modelling through incorporating magnetic resonance imaging (MRI) improves the model's biofidelity with respect to joint alignment and articulation...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.11.016
更新日期：2019-01-23 00:00:00
abstract：:Continuum-level finite element (FE) models became standard computational tools for the evaluation of bone mechanical behavior from in vivo computed tomography scans. Such scans do not account for the anisotropy of the bone. Instead, local mechanical properties in the continuum-level FE models are assumed isotropic and...
journal_title：Journal of biomechanics
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doi：10.1016/j.jbiomech.2005.10.027
更新日期：2006-01-01 00:00:00
abstract：:Overactive bladder is often characterized by biomechanical changes in the bladder wall, but there is no established method to measure these changes in vivo. The goal of this study was to develop a novel method to determine detrusor wall biomechanical parameters during urodynamics through the incorporation of transabdo...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.07.028
更新日期：2017-08-16 00:00:00
abstract：:Interactions between contacting biological surfaces may play significant roles in physiological and pathological processes. Theoretical models have described some special cases of contact, using one or more simplifying assumptions. Experimental quantification of contact could help to validate theoretical analyses. The...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.01.006
更新日期：2008-01-01 00:00:00
abstract：:Active tension developed while cardiac muscle shortens has been studied extensively under afterloaded isotonic or isovelocity conditions. However, these are not true in vivo loading conditions. To obtain more physiological loading, we controlled sarcomere length to follow the time courses that we observed previously i...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(96)00122-4
更新日期：1997-02-01 00:00:00
abstract：:About one-third of older multiparous women are prone to stress urinary incontinence (SUI): unwanted urine loss during activities which suddenly raise intra-abdominal pressure. In this paper we describe and test a method for visualizing and analyzing the function of the urinary continence control system (CCS) under str...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(97)81291-2
更新日期：1997-01-01 00:00:00
abstract：:Experimental tests, such as the confined and unconfined compression and the indentation tests, are traditionally used to determine the poroelastic properties of hydrated soft tissues (HSTs). The purpose of this study was to quantitatively evaluate the reliability of H(A) and K values as identified from experimental co...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.02.020
更新日期：2007-01-01 00:00:00
