Abstract：
:The effect of sub-cellular mechanical loads on the behavior of fibroblasts was investigated using magnetoelastic (ME) materials, a type of material that produces mechanical vibrations when exposed to an external magnetic AC field. The integration of this functionality into implant surfaces could mitigate excessive fibrotic responses to many biomedical devices. By changing the profiles of the AC magnetic field, the amplitude, duration, and period of the applied vibrations was altered to understand the effect of each parameter on cell behavior. Results indicate fibroblast adhesion depends on the magnitude and total number of applied vibrations, and reductions in proliferative activity, cell spreading, and the expression of myofibroblastic markers occur in response to the vibrations induced by the ME materials. These findings suggest that the subcellular amplitude mechanical loads produced by ME materials could potentially remotely modulate myofibroblastic activity and limit undesirable fibrotic development.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Holmes HR,Vlaisavljevich E,Tan EL,Snyder KL,Ong KG,Rajachar RMdoi
10.1016/j.jbiomech.2018.02.007subject
Has Abstractpub_date
2018-04-11 00:00:00pages
199-207eissn
0021-9290issn
1873-2380pii
S0021-9290(18)30093-9journal_volume
71pub_type
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