Abstract：
:To know the contributions of blood pressure induced stress to the progression of atherosclerosis and the rupture of atheroma, cross-sectional distributions of stresses in atherosclerotic walls were calculated by finite element method, using stress-strain data of aortic walls and atherosclerotic plaques obtained from hypercholesterolemic rabbits. In the aortic wall attached by a local plaque, circumferential tensile stress was maximal in the wall near plaque edge, and the stress value was very high compared to the tensile strength of wall media. This local stress concentration may be a contributing factor to the progression of atherosclerotic disease. In the aortic wall uniformly lined with atheroma, circumferential stress was high in the innermost layer of atheroma, and its magnitude was comparable to the tensile strength of plaque. Stress gradient at the interface between atheroma and wall was also high. These results indicate a possibility of rupture of atheroma near the intraluminal surface of atheroma or at the junction of atheroma with wall intima.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Hayashi K,Imai Ydoi
10.1016/s0021-9290(96)00185-6subject
Has Abstractpub_date
1997-06-01 00:00:00pages
573-9issue
6eissn
0021-9290issn
1873-2380pii
S0021929096001856journal_volume
30pub_type
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journal_title：Journal of biomechanics
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