Abstract:
:Implants of microporous β-tricalcium phosphate (β-TCP) were developed for primarily stable supply of bone defects. A consistent stability over the healing period should be retained in sheep. β-TCP cylindrical shaped implants, with 7 mm diameter, 25 mm length, medium pore diameter 5 μm and 40% porosity were developed. Fresh bone defects of 21 sheep in the medial femur condyle were filled with the implants. At time zero, after 6, 12 and 24 weeks the knees of each 7 animals were studied. Specimens were investigated radiologically, followed by biomechanical and histological analysis. Radiological analysis showed progressive resorption. 6 weeks after surgery results of the indentation test were slightly lower, after 12 and 24 weeks higher than on the healthy opposite knee. At 6 weeks a phagocyte reaction overbalanced. After 12 weeks bone regeneration around the implant was seen. After 24 weeks a highly advanced resorption of TCP implant was realized. The trabecular structure of the new bone increased after 24 weeks. Using microporous β-TCP implants continuous stable filling of bone defects can be reached in sheep. Microporous β-TCP implants are resorbed and replaced by bone.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Mayr HO,Suedkamp NP,Hammer T,Hein W,Hube R,Roth PV,Bernstein Adoi
10.1016/j.jbiomech.2015.01.040subject
Has Abstractpub_date
2015-04-13 00:00:00pages
1023-31issue
6eissn
0021-9290issn
1873-2380pii
S0021-9290(15)00056-1journal_volume
48pub_type
杂志文章abstract::A new technique to study the mechanical properties of collagen lattices or dermal equivalents is described. With the help of the load-extension curve obtained with a uniaxial traction apparatus, a stiffness modulus varying from 0.06 to 1 MPa is calculated from the studied parameters (duration of culture, collagen and ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/0021-9290(92)90250-5
更新日期:1992-01-01 00:00:00
abstract::The purpose of this study was to predict and explain the pattern of shear force and ligament loading in the ACL-deficient knee during walking, and to compare these results to similar calculations for the healthy knee. Musculoskeletal modeling and computer simulation were combined to calculate ligament forces in the AC...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2003.07.001
更新日期:2004-03-01 00:00:00
abstract::The feasibility of determining biphasic material properties using regression models was investigated. A transversely isotropic poroelastic finite element model of stress relaxation was developed and validated against known results. This model was then used to simulate load intensity for a wide range of material proper...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.05.028
更新日期:2013-07-26 00:00:00
abstract::The study of human locomotion and its applications are examined from a historical viewpoint. Several critical steps in the advancement of the discipline are considered in the context of addressing a particular need to answer fundamental questions regarding the process of human locomotion. In addition, changes in the m...
journal_title:Journal of biomechanics
pub_type: 杂志文章,评审
doi:10.1016/s0021-9290(00)00061-0
更新日期:2000-10-01 00:00:00
abstract::A three-dimensional model of the lower limb containing 47 muscles was developed to study the differences between a two- and three-dimensional approach for determining internal loads, the role of the dynamic joint representation, and the behavior of different load-bearing criteria in walking and running. The problem of...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(97)00089-4
更新日期:1997-11-01 00:00:00
abstract::The biomechanical characteristics of bone tissue and its cells under mechanical stress are significant for bone biomechanics research, but the mechanism of mechanotransduction is still unknown. It has been established that the actin cytoskeleton of osteoblasts plays an important role in this process. However, the stru...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.08.010
更新日期:2008-11-14 00:00:00
abstract::This paper presents a practical and effective approach to the calibration of instrumented spatial linkages for biomechanical applications. A 6-DOF mechanical linkage with rotational transducers is designed and in-house manufactured for this purpose. In order to assess the validity of the proposed calibration technique...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2006.06.021
更新日期:2007-01-01 00:00:00
abstract::The effect of screw-bone interface modelling strategies was evaluated in the setting of a tibial mid-shaft fracture stabilised using locking plates. Three interface models were examined: fully bonded interface; screw with sliding contact with bone; and screw with sliding contact with bone in an undersized pilot hole. ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2012.04.008
更新日期:2012-06-01 00:00:00
abstract::Osteogenesis imperfecta (OI) is a heritable disease, which results from an abnormal amount or structure of Type I collagen. Bisphosphonates, a class of synthetic antiresorptive drugs, used in osteoporosis management, are also used to decrease fracture incidence and improve quality of life in children with OI. In this ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.09.028
更新日期:2008-12-05 00:00:00
abstract::In order to move the finger the tendon force must overcome the gliding resistance of the tendon as well as the forces to move the joints, finger inertias, and external load. These sources, combined, make up the work of flexion (WOF) which has been experimentally used to evaluate the finger function. In this study, we ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(02)00300-7
更新日期:2003-02-01 00:00:00
abstract::This work is a novel attempt to incorporate computational fluid dynamics (CFD) techniques in the analysis of hemodynamic parameters of Moyamoya disease (MMD). Highly prevalent in Asian countries, MMD is characterised by progressive occlusion of the intracranial Internal Carotid Arteries (ICA). We intend to identify a ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2014.11.029
更新日期:2015-01-21 00:00:00
abstract::Whole body vibration (WBV) is a promising tool for counteracting bone loss. Most WBV studies on animals have been performed at acceleration <1g and frequency between 30 and 90Hz. Such WBV conditions trigger bone growth in osteopenia models, but not in healthy animals. In order to test the ability of WBV to promote ost...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.04.031
更新日期:2016-06-14 00:00:00
abstract::Previous studies evaluated 3D human jaw movements using kinematic analysis systems during mouth opening, but information on the reliability of such measurements is still scarce. The purpose of this study was to analyze within- and between-session reliabilities, inter-rater reliability, standard error of measurement (S...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2017.09.038
更新日期:2017-11-07 00:00:00
abstract::Rigid body attitude and single-joint kinematics are typically expressed using three Cardan angles which represent rotations in anatomical planes. It was recently shown in the Biomechanics literature that Cardan angles inaccurately estimate true mean attitude due to an important mathematical inadequacy: attitude under-...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109976
更新日期:2020-10-09 00:00:00
abstract::Falls due to slipping are a serious concern, with slipping estimated to cause 40-50% of all fall-related injuries. Epidemiological data indicates that older and obese adults experience more falls than young, non-obese individuals. An increasingly heavier and older U.S. population and workforce may be exacerbating the ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2016.01.018
更新日期:2016-03-21 00:00:00
abstract::Joint distraction and mobilization with a hinged external fixator preserves elbow stability and mobility. However, the alignment of both elbow and fixator hinges was the initial prerequisite of the arthrodiatasis technique. The main goal of this study was to numerically evaluate the kinematic influence of the device, ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2009.07.030
更新日期:2010-03-03 00:00:00
abstract::The coronary arteries undergo large dynamic variations during each cardiac cycle due to their position on the beating heart. The local artery curvature varies significantly. In this study the influence of dynamic curvature on coronary artery hemodynamics is analyzed numerically. A realistic model of the bifurcation of...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2004.01.021
更新日期:2004-11-01 00:00:00
abstract::Uncrimping of collagen fibers in the arterial wall is an integral process in regulating the macro-level mechanical response of arteries. Uncrimping of collagen fibers leads to a gradual, but significant strain-stiffening response of the artery at physiological pressures and prevents overdistention at elevated pressure...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2013.08.001
更新日期:2013-10-18 00:00:00
abstract::The goal of the present study was to assess the effects of age and sex on trunk motor control. Fifty healthy adults (aged between 19 and 67 years, 28 males) participated in this study. Trunk motor control was assessed using force-controlled perturbations directly applied to the trunk. Admittance (inverse of lumped int...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109607
更新日期:2020-03-26 00:00:00
abstract::Understanding the mechanisms of instability can aid in reducing fall risk. As a sensitive measure of fall risk, the distance between the center of pressure (COP) and center of mass (COM) is currently assessed through discrete points assumed to represent physiological important fall mechanisms. However, it is unclear i...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2020.109899
更新日期:2020-07-17 00:00:00
abstract::Studying mechanics of the muscles spanning multiple joints provides insights into intersegmental dynamics and movement coordination. Multiarticular muscles are thought to function at "near-isometric" lengths to transfer mechanical energy between the adjacent body segments. Flexor hallucis longus (FHL) is a multiarticu...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2008.03.040
更新日期:2008-01-01 00:00:00
abstract::To confirm the existence of epimuscular myofascial force transmission in humans, this study examined if manipulating joint angle to stretch the muscle can alter the shear modulus of a resting adjacent muscle, and whether there are regional differences in this response. The biceps brachii (BB: manipulated muscle) and t...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2018.04.036
更新日期:2018-06-06 00:00:00
abstract::Among the most common causes of upper extremity fracture is a fall on the outstretched hand. Yet few data exist on the biomechanical factors which affect injury risk during this event. In this study, we measured impact forces during low-height (0-5 cm), forward falls onto the outstretched hand, and found that these ar...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(98)00137-7
更新日期:1998-12-01 00:00:00
abstract::Cancellous bone architecture and mechanics are intimately related. The trabecular architecture of cancellous bone is considered determined by its mechanical environment (Wolff's law), and the mechanical properties of cancellous bone are inversely determined by the trabecular architecture and material properties. Much ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/s0021-9290(96)00177-7
更新日期:1997-05-01 00:00:00
abstract::The reverse shoulder prosthesis aims to restore the stability and function of pathological shoulders, but the biomechanical aspects of the geometrical changes induced by the implant are yet to be fully understood. Considering a large-scale musculoskeletal model of the upper limb, the aim of this study is to evaluate h...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.06.031
更新日期:2015-09-18 00:00:00
abstract::Understanding the mechanical behaviour of arterial tissue is vital to the development and analysis of medical devices targeting diseased vessels. During angioplasty and stenting, stress softening and permanent deformation of the vessel wall occur during implantation of the device, however little data exists on the ine...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2012.02.026
更新日期:2012-05-11 00:00:00
abstract::Although we sometimes use the intrasynovial tendon allograft as a donor, the gliding ability of allograft prepared by lyophilization is significantly decreased. The gliding ability of the grafted tendon after tendon reconstruction is very important because the high gliding resistance causes more adhesion and leads to ...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.12.030
更新日期:2011-06-03 00:00:00
abstract::In cementless total hip arthroplasty, osteoporosis may jeopardize the achievement of immediate stability and lead to migration of anatomically shaped femoral stems. Poor quality of proximal cancellous bone per se may also affect the rate of osseointegration. In a selected group of female total hip arthroplasty patient...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2010.10.012
更新日期:2011-01-11 00:00:00
abstract::To improve the treatments for low back pain, new designs of total disk replacement have been proposed. The question is how well these designs can act as a functional replacement of the intervertebral disk. Four finite element models were made, for four different design concepts, to determine how well they can mimic th...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2011.09.017
更新日期:2012-01-03 00:00:00
abstract::The purpose of this study was to employ subject-specific computer models to evaluate the interaction of glenohumeral range-of-motion and Hill-Sachs humeral head bone defect size on engagement and shoulder dislocation. We hypothesized that the rate of engagement would increase as defect size increased, and that greater...
journal_title:Journal of biomechanics
pub_type: 杂志文章
doi:10.1016/j.jbiomech.2015.11.001
更新日期:2016-02-29 00:00:00