Abstract：
:Osteogenesis imperfecta (OI) is a heritable disease, which results from an abnormal amount or structure of Type I collagen. Bisphosphonates, a class of synthetic antiresorptive drugs, used in osteoporosis management, are also used to decrease fracture incidence and improve quality of life in children with OI. In this study, we used the oim mouse to test the hypotheses that pamidronate treatment during active growth (1) produces larger, stronger, stiffer long bone diaphyses without altering bone material properties, and (2) negatively impacts longitudinal bone growth. Our results indicate that femoral cross-sectional moment of inertia in the distal metaphysis tended to increase with pamidronate treatment and that the treated bones are thicker and structurally stiffer, but shorter than their control-dose counterparts.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Rao SH,Evans KD,Oberbauer AM,Martin RBdoi
10.1016/j.jbiomech.2008.09.028subject
Has Abstractpub_date
2008-12-05 00:00:00pages
3371-6issue
16eissn
0021-9290issn
1873-2380pii
S0021-9290(08)00490-9journal_volume
41pub_type
杂志文章abstract：:The purpose of this study was to determine the accuracy of a video system which our laboratory has been using to measure soft tissue strain. Both static and dynamic error analyses were performed to assess the accuracy of our video system. Static error was defined as the amount of movement reported by the video system ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(95)00131-x
更新日期：1996-06-01 00:00:00
abstract：:This paper shows how information on the fatigue behaviour of microcracks can be obtained by the analysis of stiffness changes measured during cyclic loading. Relationships between crack length, growth rate and cyclic stress intensity were deduced, and compared with previous empirical equations. Results show that the c...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(98)00050-5
更新日期：1998-07-01 00:00:00
abstract：:More extensive characterization of trabecular connectivity and intertrabecular space will be instrumental in understanding disease states and designing engineered bone. This project presents an experimental protocol to define the directional dependence of transport properties as measured from healthy cancellous bone w...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(01)00082-3
更新日期：2001-09-01 00:00:00
abstract：:Development of biologically inspired exoskeletons to assist soldiers in carrying load is a rapidly expanding field. Understanding how the body modulates stiffness in response to changing loads may inform the development of these exoskeletons and is the purpose of the present study. Seventeen subjects walked on a tread...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.12.046
更新日期：2015-04-13 00:00:00
abstract：:The purpose of the present study was to investigate the effects of mechanical strain, anisotropy, and tissue region on electrical conductivity and ion diffusivity in meniscus fibrocartilage. A one-dimensional, 4-wire conductivity experiment was employed to measure the electrical conductivity in porcine meniscus tissue...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.06.011
更新日期：2016-09-06 00:00:00
abstract：:Three-dimensional gait analysis (3D-GA) is commonly used to answer clinical questions of the form "which joints and what variables are most affected during when". When studying high-dimensional datasets, traditional dimension reduction methods (e.g. principal components analysis) require "data flattening", which may m...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.04.035
更新日期：2019-06-11 00:00:00
abstract：:The second part of this study of the six axes of head motion caused by translational seat vibration is concerned with the effect of fore-and-aft (x-axis) and lateral (y-axis) seat vibration. Seat-to-head transmissibilities have been determined at frequencies up to 16 Hz for each of the three translational and three ro...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(88)90170-4
更新日期：1988-01-01 00:00:00
abstract：:In recent years, there has been a surge of interest in magnesium (Mg) and its alloys as biomaterials for orthopaedic applications, as they possess desirable mechanical properties, good biocompatibility, and biodegradability. Also shown to be osteoinductive, Mg-based materials could be particularly advantageous in func...
journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2013.12.003
更新日期：2014-06-27 00:00:00
abstract：:The motor module hypothesis in motor control proposes that the nervous system can simplify the problem of controlling a large number of muscles in human movement by grouping muscles into a smaller number of modules. Here, we tested one prediction of the modular organization hypothesis by examining whether there is pre...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.02.006
更新日期：2016-03-21 00:00:00
abstract：:A three-dimensional finite element model of the human head is presented. The model has been validated against two sets of experimental results. To assess injury likelihood of the head subjected to impact loading, the structural intensity (SI) methodology is introduced in accordance with the prevailing practice in expe...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.11.015
更新日期：2006-01-01 00:00:00
abstract：:Biomechanical models may aid in improving diagnosis and treatment of wrist joint disorders. As input, geometrical information is required for model development. Previous studies acquired some elements of the average wrist joint geometry. However, there is a close geometric functional match between articulating surface...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.11.003
更新日期：2010-03-22 00:00:00
abstract：:A method for measuring three-dimensional kinematics that incorporates the direct cross-registration of experimental kinematics with anatomic geometry from Computed Tomography (CT) data has been developed. Plexiglas registration blocks were attached to the bones of interest and the specimen was CT scanned. Computer mod...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00195-0
更新日期：2001-03-01 00:00:00
abstract：:Microdamage occurs in trabecular bone under normal loading, which impairs the mechanical properties. Architectural degradation associated with osteoporosis increases damage susceptibility, resulting in a cumulative negative effect on the mechanical properties. Treatments for osteoporosis could be targeted toward incre...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.09.002
更新日期：2011-11-10 00:00:00
abstract：:An asymptotic analysis of a lubrication problem is presented for a model of articular cartilage and synovial fluid under the squeeze-film condition. This model is based upon the following constitutive assumptions: (1) articular cartilage is a linear porous-permeable biphasic material filled with a linearly viscous flu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(92)90024-u
更新日期：1992-03-01 00:00:00
abstract：:Muscle compression commonly occurs in daily life (for instance wearing backpacks or compression garments, and during sitting). However, the effects of the compression on contraction dynamics in humans are not well examined. The aim of the study was to quantify the alterations of contraction dynamics and muscle archite...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.01.011
更新日期：2019-03-06 00:00:00
abstract：:Given the complex three-dimensional (3D) knee joint loading associated with anterior cruciate ligament (ACL) injuries, accurate site- and bundle-specific strain measurements are critical. The purpose of this study was to quantify tensile load-induced migrations of radio-opaque markers injected directly into the ACL, a...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.08.016
更新日期：2012-10-11 00:00:00
abstract：:Proper cup alignment is crucial in total hip arthroplasty for reducing impingement risks, dislocations and wear. The Lewinnek "safe zone" is often used in clinical routine. This safe zone does not consider functional aspects and dislocation can occur even when the cup is oriented within the safe zone. Functional safe ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2018.10.020
更新日期：2019-01-03 00:00:00
abstract：:As plaque develops in arteries two types of remodeling can occur; positive and negative remodeling. Positive remodeling is an outward compensatory remodeling in which the arterial wall grows outward in an attempt to maintain a constant lumen diameter, while negative remodeling is defined as a local shrinkage of vessel...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.02.012
更新日期：2013-04-26 00:00:00
abstract：:This study examined the influence of a mechanical perturbation of the ankle joint on obstacle avoidance pattern. A decoupled control between the distal joint and the combined (hip-knee) proximal joints was observed according to the task requirement. In this context, a greater mechanical friction at the ankle should be...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2004.07.019
更新日期：2005-07-01 00:00:00
abstract：:Blast pulmonary trauma are common consequences of modern war and terrorism action. To better protect soldiers from that threat, the injury risk level when protected and unprotected must be assessed. Knowing from the literature that a possible amplification of the blast threat would be provided by some thoracic protect...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.02.011
更新日期：2019-03-27 00:00:00
abstract：:We previously reported an ultrasound method for measuring the depth-dependent equilibrium mechanical properties of articular cartilage using quasi-static compression. The objective of this paper was to introduce our recent development for nondestructively measuring the transient depth-dependent strains of full-thickne...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.08.020
更新日期：2005-09-01 00:00:00
abstract：:The active control of the trunk plays an important role in frontal plane gait stability. We characterized trunk control in response to different step widths using a novel feedback system and examined the different effects of wide and narrow step widths as they each present unique task demands. Twenty healthy young adu...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.110135
更新日期：2021-01-04 00:00:00
abstract：:Hamstring muscle strain injury is one of the most common injuries in sports involving sprinting and kicking. Studies examining hamstring kinematics and activations are rich for sprinting but lacking for kicking. The purpose of this study was to examine kinematics and activations of hamstring muscles in instep and cut-...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.109482
更新日期：2020-01-23 00:00:00
abstract：:This paper discusses the manner in which random Gaussian errors affect the determination of body segment kinematics. For the process of modelling rigid body (RB) motion, three types of kinematic errors, input, measured and theoretical, are identified. These correspond to errors in: the determination of three-dimension...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(96)00008-5
更新日期：1996-09-01 00:00:00
abstract：:Novel strategies to heal discogenic low back pain could highly benefit from comprehensive biophysical studies that consider both mechanical and biological factors involved in intervertebral disc degeneration. A decrease in nutrient availability at the bone-disc interface has been indicated as a relevant risk factor an...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.02.004
更新日期：2014-04-11 00:00:00
abstract：:Bone, a tri-phase composite, consists of nano-sized apatite minerals, an organic component, and water. Heat-treated bovine cortical bone has been proposed as a candidate for void-filling bone substitute. However, the toughness of heat-treated bone is not yet fully studied. Fracture toughness (K(c)) and work of fractur...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2008.03.037
更新日期：2008-01-01 00:00:00
abstract：:A design is presented for a bicycle pedal dynamometer that measures both normal and tangential forces (i.e. driving forces). Mechanical decoupling is used to reduce the cross-sensitivity of the dynamometer to loads doing no work to propel the bicycle. This obviates the need to measure all six loads for accurate data r...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(88)90144-3
更新日期：1988-01-01 00:00:00
abstract：:Transitory tasks, such as gait termination, involve interactions between neural and biomechanical factors that challenge postural stability and head stabilization patterns in older adults. The aim of the study was to compare upper body patterns of acceleration during planned gait termination at different speeds betwee...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.10.019
更新日期：2017-12-08 00:00:00
abstract：:The measurement of relative motion between two moving bones is commonly accomplished for in vitro studies by attaching to each bone a series of either passive or active markers in a fixed orientation to create a rigid body (RB). This work determined the accuracy of motion between two RBs using an Optotrak optical moti...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.01.017
更新日期：2007-01-01 00:00:00
abstract：:The application of tissue-engineered cartilage in a clinical setting requires a noninvasive method to assess the biophysical and biochemical properties of the engineered cartilage. Since articular cartilage is composed of 70-80% water and has dense extracellular matrixes (ECM), it is considered that the condition of t...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.02.002
更新日期：2007-01-01 00:00:00
