Abstract：
:More extensive characterization of trabecular connectivity and intertrabecular space will be instrumental in understanding disease states and designing engineered bone. This project presents an experimental protocol to define the directional dependence of transport properties as measured from healthy cancellous bone when considered as a biologic, porous medium. In the initial design phases, mature bovine bone was harvested from the femoral neck (n=6 cylinders) and distal condyle (n=4 cubes) regions and used for "proof of concept" experimentation. A power study on those results led to the presented work on 20 cubic samples (mean volume=4.09cm(3)) harvested from a single bovine distal femur. Anisotropic intrinsic permeabilities (k(i)) were quantified along the orthogonal anatomic axes (i=medial-lateral, anterior-posterior, and superior-inferior) from each individual cubic bone sample. Using direct perfusion measurements, permeability was calculated based upon Darcy's Law describing flow through porous media. The maximum mean value was associated with the superior-inferior orientation (4.65x10(-10)m(2)) in comparison with the mean anterior-posterior (4.52x10(-10)m(2)) and medial-lateral (2.33x10(-10)m(2)) direction values. The results demonstrate the anisotropic (p=0.0143) and heterogeneous (p=0.0002) nature of the tissue and encourage the ongoing quantification of parameters within the established poroelastic models.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Kohles SS,Roberts JB,Upton ML,Wilson CG,Bonassar LJ,Schlichting ALdoi
10.1016/s0021-9290(01)00082-3keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
1197-202issue
9eissn
0021-9290issn
1873-2380pii
S0021929001000823journal_volume
34pub_type
杂志文章abstract：:A new transducer was developed for in situ measurement of the force vector in a complex muscle. The transducer measures the magnitude, and the line of action of a force in a single plane. The dynamic range of the transducer is 0-5 N. This range includes the small forces developed by an active motor unit and the relati...
journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
abstract：:Gait analysis is a quantitative, non-invasive technique that can be used to investigate functional changes in animal models of musculoskeletal disease. Changes in ground reaction forces following injury have been observed that coincide with differences in tissue mechanical and histological properties during healing. H...
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更新日期：2016-02-08 00:00:00
abstract：:Although arterial blood flow is physiologically non-periodic under resting conditions, periodic flow assumption has been widely adopted in most hemodynamic studies. So far, it remains unclear how the non-periodicity of blood flow would influence local hemodynamic parameters, especially wall shear stress (WSS) that ass...
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更新日期：2020-03-05 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.06.022
更新日期：2010-10-19 00:00:00
abstract：:In a newly developed, highly sensitive dilatometer we applied pulsatile electric fields to five dry bone samples cut from mid-tibial sections within a 90 degrees angle from the rear to front axis. Samples of five cows were studied. We measured the piezoelectric coefficient d23 establishing its mean and confidence inte...
journal_title：Journal of biomechanics
pub_type： 杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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abstract：:Osteoarthritis (OA) is typically diagnosed in humans in its final stage when joint movement becomes painful. Clinical information about the onset and the mechanisms triggering the degenerative responses are virtually non-existent. However, research on animal models of experimental OA shows that joint adaptations assoc...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(97)00119-x
更新日期：1998-03-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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abstract：:Bilateral asymmetry in gallop stride limb contact patterns of four Quarter Horse fillies was documented by high-speed cinematography. Horses were filmed with rider by two cameras simultaneously while galloping along a straightaway. Even though signaled for each gallop lead an equivalent number of times, horses frequen...
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00245-8
更新日期：2004-02-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.109939
更新日期：2020-08-26 00:00:00
abstract：:An anatomically accurate human upper airway model was constructed from multiple magnetic resonance imaging axial scans. This model was used to conduct detailed Computational Fluid Dynamics (CFD) simulations during expiration, to investigate the fluid flow in the airway regions where obstruction could occur. An identic...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.03.035
更新日期：2009-07-22 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.12.030
更新日期：2011-06-03 00:00:00
abstract：:The objective of this work is to gain more insight into the processes of oral perception of food texture. Particularly, the limits for detectable thickness differences of objects, which are evaluated in the human mouth, are investigated. In a sensory study small, flexible circular disks (diameter in mm range) of varyi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2007.04.012
更新日期：2007-01-01 00:00:00
abstract：:In this article, the tensile properties of gastric wall were investigated by using biomechanical test and theoretical analysis. The samples of porcine stomach strips from smaller and greater curvature of the stomach were cut in longitudinal and circumferential direction, respectively. The loading-unloading, stress rel...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2014.12.048
更新日期：2015-02-26 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.01.003
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abstract：:Nanoindentation has been widely used as a means to measure the micro-mechanical properties of bone and to predict the macroscopic properties. The role of indent depth and indenter tip geometry in measuring the hierarchical properties of bone tissue was explored experimentally using a range of spherical indenter tips o...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.10.008
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.08.047
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(92)90261-x
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00110-x
更新日期：2000-12-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2006.11.004
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.08.023
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abstract：:Total cavopulmonary connection is the result of a series of palliative surgical repairs performed on patients with single ventricle heart defects. The resulting anatomy has complex and unsteady hemodynamics characterized by flow mixing and flow separation. Although varying degrees of flow pulsatility have been observe...
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pub_type： 临床试验,杂志文章,多中心研究
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2015.12.022
更新日期：2016-05-24 00:00:00
abstract：:Locomotion of the horse is simulated using a mathematical model based on rigid body dynamics. A general method to generate the equations of motion for a two-dimensional rigid body model with an arbitrary number of hinge joints is presented and a numerical solution method, restricted to tree-structured models, is descr...
journal_title：Journal of biomechanics
pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
