Abstract：
:Pressure ulcers are debilitating wounds that arise frequently in people who have lost mobility. Mechanical stress, oxidative stress and ischemia-reperfusion injury are potential sources of damage during pressure ulcer formation, but cross-talk between these sources has rarely been investigated. In vitro experiments with mechanically-induced cell damage previously demonstrated that non-lethal amounts of static cell deformation could induce myoblast membrane permeabilization. Permeabilization, in turn, has the potential to induce oxidative stress via leakage of calcium, myoglobin or alarmins. In this work, we constructed a hypothetical causal network of cellular-scale effects resulting from deformation and permeabilization, and we investigated the theoretical sensitivity of cell death toward various parameters and pathways of the model. Simulations showed that the survival/death outcome was particularly sensitive to the speed of membrane repair. The outcome was also sensitive to whether oxidative stress could decrease the speed of membrane repair. Finally, using the assumption that apoptosis and necrosis would have opposite effects on membrane leakage in dying cells, we showed that promoting apoptosis might under certain conditions have the paradoxical effect of decreasing, rather than increasing, total cell death. Our work illustrates that apoptosis may have hidden benefits at preventing spatial spread of death. More broadly, our work shows the importance of membrane repair dynamics and highlights the need for experiments to measure the effects of ischemia, apoptosis induction, and other co-occurring sources of cell stress toward the speed of membrane repair.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Jagannathan NS,Tucker-Kellogg Ldoi
10.1016/j.jbiomech.2015.12.022subject
Has Abstractpub_date
2016-05-24 00:00:00pages
1311-1320issue
8eissn
0021-9290issn
1873-2380pii
S0021-9290(15)00728-9journal_volume
49pub_type
杂志文章abstract：:Morphometrical and postural features of the cervical spine are supposed to significantly influence its biomechanical behaviour. However, the effects of these geometrical parameters are quite difficult to evaluate. An original numerical method is proposed in order to automatically generate parametric and subject-specif...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.04.007
更新日期：2009-07-22 00:00:00
abstract：:In this review of patellofemoral joint forces as they might apply to implant design, methodologies for estimating forces on the patella and estimates of the forces, as reported in the literature, are summarized. Two methodologies exist for studying joint loads; one that measures kinematics in-vivo and uses analysis to...
journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
doi：10.1016/j.jbiomech.2008.04.039
更新日期：2008-08-07 00:00:00
abstract：:During range of motion (max-ROM) tests performed on an isokinetic dynamometer, the mechanical delay between the button press (by the participant to signal their max-ROM) and the stopping of joint rotation resulting from system inertia induces errors in both max-ROM and maximum passive joint moment. The present study a...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2019.05.036
更新日期：2019-07-19 00:00:00
abstract：:The purpose of the current paper was to use the energy approach to develop a simplified equation for quantifying individual muscle contributions to mechanical stability about all three axes of a particular joint. Specific examples are provided for muscles acting about the lumbar spine's L4/L5 joint. The stability equa...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.06.004
更新日期：2005-05-01 00:00:00
abstract：:This study looks at pulsatile blood flow through four different right coronary arteries, which have been reconstructed from biplane angiograms. A non-Newtonian blood model (the Generalised Power Law), as well as the usual Newtonian model of blood viscosity, is used to study the wall shear stress in each of these arter...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.01.034
更新日期：2006-01-01 00:00:00
abstract：:Muscles coordinate multijoint motion by generating forces that cause reaction forces throughout the body. Thus, a muscle can redistribute existing segmental energy by accelerating some segments and decelerating others. In the process, a muscle may also produce or absorb energy, in which case its summed energetic effec...
journal_title：Journal of biomechanics
pub_type：
doi：10.1016/s0021-9290(02)00046-5
更新日期：2002-08-01 00:00:00
abstract：:The objective of this study was to examine the use of the continuous wavelet transform (CWT) on surface electromyographic (sEMG) signals acquired from the lower extremity muscles during gait in children with typical development (TD) and cerebral palsy (CP). This was done to explore the possibility of developing a quan...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/j.jbiomech.2004.07.002
更新日期：2005-06-01 00:00:00
abstract：:In this work we propose a method to estimate the elastic properties of the extracellular matrix of articular cartilage, once the elastic properties of the chondrocytes and the whole tissue are known. The influence of the elastic properties of the tissue and the cell concentration on the estimated elastic properties of...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(03)00280-x
更新日期：2004-03-01 00:00:00
abstract：:A method for measuring three-dimensional kinematics that incorporates the direct cross-registration of experimental kinematics with anatomic geometry from Computed Tomography (CT) data has been developed. Plexiglas registration blocks were attached to the bones of interest and the specimen was CT scanned. Computer mod...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00195-0
更新日期：2001-03-01 00:00:00
abstract：:Tripping is responsible for a large percentage of falls. Minimum toe clearance (MTC) during the swing phase of gait is commonly used to infer the probability of tripping (POT). However, there is limited empirical evidence to support the relationship between these two variables, and other measures of toe trajectory may...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.10.045
更新日期：2016-12-08 00:00:00
abstract：:Starting from the laws of thermodynamics of reversible processes, a temperature-dependent constitutive equation is derived for the elastic force-length relation of soft biological tissues. These tissues are composed of a network of fibres (mainly collagen). The equation is based on a model which uses a simplified two-...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(89)90222-4
更新日期：1989-01-01 00:00:00
abstract：:Upper extremity musculoskeletal disorders represent an important health issue across all industry sectors; as such, the need exists to develop models of the hand that provide comprehensive biomechanics during occupational tasks. Previous optical motion capture studies used a single marker on the dorsal aspect of finge...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2011.04.003
更新日期：2011-06-03 00:00:00
abstract：:Uniaxial tensile tests are commonly used to characterize the structural and material properties of tendons and ligaments. During these tests, the stress and strain distributions applied to the specimen are assumed to be uniform. However, few studies have investigated the strain distributions throughout the tissue. The...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2004.12.021
更新日期：2006-01-01 00:00:00
abstract：:Muscle activity has previously been suggested to minimize soft-tissue resonance which occurs at heel-strike during walking and running. If this concept were true then the greatest vibration damping would occur when the input force was closest to the resonant frequency of the soft-tissues at heel-strike. However, this ...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0021-9290(03)00216-1
更新日期：2003-12-01 00:00:00
abstract：:A device is described for measuring strength and power outputs of dynamic vertical lifts between heights of 0.4 and 2.2 m. The device is safe, robust, and easily transportable. It consists of a water-filled tube 2 m high and 200 mm internal diameter. The subject pulls vertically on a handle which is connected with fle...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(96)00155-8
更新日期：1997-04-01 00:00:00
abstract：:Static stretching is a major type of mechanical stimuli utilized during distraction osteogenesis (DO), a general surgical method for the lengthening of bone. The molecular signals that drive the regenerative process in DO include a variety of cytokines. Among these, bone morphogenic protein (BMP, -2 and -4) has been r...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.08.006
更新日期：2009-12-11 00:00:00
abstract：:Continuous flow blood fraction separators are used to facilitate the removal of specific blood components for donation or for certain medical procedures. Problems with one such device, the IBM 2997 Blood Processor, have been noted in a number of independent investigations. A key feature of this particular unit is a ce...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(86)90163-6
更新日期：1986-01-01 00:00:00
abstract：:The purpose of this study was to compare the forces and moments of the whole upper limb, analyzing forces and moments at the shoulder, elbow and wrist joints simultaneously during manual wheelchair propulsion of persons with different levels of spinal cord injury (SCI) on a treadmill. Fifty-one people participated in ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2010.05.021
更新日期：2010-09-17 00:00:00
abstract：:A novel technique to measure in vitro disc pressures in human cervical spine specimens was developed. A miniature pressure transducer was used and an insertion technique was designed to minimise artefacts due to insertion. The technique was used to measure the intradiscal pressure in cervical spines loaded in pure axi...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/s0021-9290(00)00205-0
更新日期：2001-04-01 00:00:00
abstract：:Transitory tasks, such as gait termination, involve interactions between neural and biomechanical factors that challenge postural stability and head stabilization patterns in older adults. The aim of the study was to compare upper body patterns of acceleration during planned gait termination at different speeds betwee...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2017.10.019
更新日期：2017-12-08 00:00:00
abstract：:In a previous study we were able to accurately fit experimental data on arterial tissues at supra-physiological loads using a material model that accounts for softening/damage only in the portion of the model associated with the collagen fibers (Weisbecker et al., 2012). Naturally, this result leads to the hypothesis ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.04.025
更新日期：2013-07-26 00:00:00
abstract：:Evaluation of anterior laxity of the ankle joint complex is a difficult clinical problem. Currently, the prime determinant for anterolateral ligament function is the subjective manual examination of anterior laxity of the ankle joint complex. An instrumented dynamic test was developed for objective measurement of ante...
journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
doi：10.1016/s0021-9290(02)00189-6
更新日期：2002-12-01 00:00:00
abstract：:The patchy distribution of atherosclerosis within arteries is widely attributed to local variation in haemodynamic wall shear stress (WSS). A recently-introduced metric, the transverse wall shear stress (transWSS), which is the average over the cardiac cycle of WSS components perpendicular to the temporal mean WSS vec...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.11.035
更新日期：2017-01-04 00:00:00
abstract：:The dynamics of arterial wall remodeling was studied on the basis of a phenomenological mathematical model. Sustained hypertension was simulated by a step increase in blood pressure. Remodeling rate equations were postulated for the evolution of the geometrical dimensions that characterize the zero stress state of the...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(95)00108-5
更新日期：1996-05-01 00:00:00
abstract：:Torsion is an important testing modality commonly used to calculate structural properties of long bones. However, the effects of size and geometry must be excluded from the overall structural response in order to compare material properties of bones of different size, age and species. We have developed a new method to...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2009.04.019
更新日期：2009-08-07 00:00:00
abstract：:The mechanical energy expenditures (MEEs) of two human lower extremity models with different sources of mechanical energy - (1) muscles and (2) joint moments - were compared theoretically. Sources of mechanical energy producing movement of Model 1 were eight muscle, three of which were two-joint muscles. Sources of me...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(95)00083-6
更新日期：1996-04-01 00:00:00
abstract：:Clinical decisions on interventions to improve function in children with cerebral palsy (CP) are based, in part, on hypothesized interactions amongst physical signs of CP and functional deficits. However, a knowledge gap exists regarding associations between spasticity and gait function. This study quantified associat...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.110218
更新日期：2021-01-16 00:00:00
abstract：:Hypoplastic left heart syndrome (HLHS) represents approximately 9% of all congenital heart defects and is one of the most complex, with the left side of the heart being generally underdeveloped. Numerous studies demonstrate that intracardiac fluid flow patterns in the embryonic and fetal circulation can impact cardiac...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2020.110035
更新日期：2020-11-09 00:00:00
abstract：:Electromyography (EMG) biofeedback training affords patients a better sense of the different muscle activation patterns involved in the movement of the shoulder girdle. It is important to address scapular kinematics with labourers who have daily routines involving large amounts of lifting at shoulder level or higher. ...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2016.04.036
更新日期：2016-06-14 00:00:00
abstract：:Implanted cartilage replacements (ICRs) are a promising approach to restore the functionality of joints with partial- and full-thickness articular cartilage lesions. Two major hurdles hindering successful repair of cartilage injuries with ICRs are their inadequate mechanical properties and fixation into the defect are...
journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.03.019
更新日期：2013-05-31 00:00:00
