Synthesis and characterization of a nanocrystalline diamond aerogel.

abstract：:In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopaminergic neurotransmi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bibb JA,Yan Z,Svenningsson P,Snyder GL,Pieribone VA,Horiuchi A,Nairn AC,Messer A,Greengard P

更新日期：2000-06-06 00:00:00

abstract：:B-G antigens are cell-surface molecules encoded by a highly polymorphic multigene family located in the chicken major histocompatibility complex (MHC). Rabbit antisera to B-G molecules immunoprecipitate 3-6 bands from iodinated erythrocytes by sodium dodecyl sulfate (SDS) gels under reducing conditions. These are all ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman J,Salomonsen J,Skjødt K,Thorpe D

更新日期：1990-11-01 00:00:00

abstract：:Legionella pneumophila is an intracellular parasite of freshwater protozoa and human macrophages. Recent studies determined that the macrophage infectivity potentiator (Mip) surface protein, a prokaryotic homolog of the FK506-binding proteins, is required for optimal infection of macrophages. To determine whether Mip ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cianciotto NP,Fields BS

更新日期：1992-06-01 00:00:00

abstract：:What are the origins of humans' capacity to represent social relations? We approached this question by studying human infants' understanding of social dominance as a stable relation. We presented infants with interactions between animated agents in conflict situations. Studies 1 and 2 targeted expectations of stabilit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mascaro O,Csibra G

更新日期：2012-05-01 00:00:00

abstract：:Thermal macrophysiology is an established research field that has led to well-described patterns in the global structuring of climate adaptation and risk. However, since it was developed primarily in animals, we lack information on how general these patterns are across organisms. This is alarming if we are to understa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lancaster LT,Humphreys AM

更新日期：2020-06-16 00:00:00

abstract：:We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L. The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a "shear thinning" response over a large range of pulling velocities, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brochard-Wyart F,Borghi N,Cuvelier D,Nassoy P

更新日期：2006-05-16 00:00:00

abstract：:Ca2+ influx through voltage-gated Ca2+ channels and the resulting elevation of intracellular Ca2+ concentration, [Ca2+]i, triggers transmitter release in nerve terminals. However, it is controversial whether in addition to the opening of Ca2+ channels, membrane potential directly affects transmitter release. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felmy F,Neher E,Schneggenburger R

更新日期：2003-12-09 00:00:00

abstract：:Insulin resistance, obesity, diabetes, dyslipidemia, and nonalcoholic fatty liver are components of the metabolic syndrome, a disease complex that is increasing at epidemic rates in westernized countries. Although proinflammatory cytokines have been suggested to contribute to the development of these disorders, the mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueki K,Kondo T,Tseng YH,Kahn CR

更新日期：2004-07-13 00:00:00

abstract：:Cultures were prepared of embryonic cells from Drosophila melanogaster. Neurons and myocytes differentiated in vitro from their respective stem cells. Electron microscopy showed that neuromuscular junctions formed where axons contacted myocytes. Electrical stimuli were applied to axons and these caused contractions of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seecof RL,Teplitz RL,Gerson I,Ikeda K,Donady J

更新日期：1972-03-01 00:00:00

abstract：:Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirotsou M,Zhang Z,Deb A,Zhang L,Gnecchi M,Noiseux N,Mu H,Pachori A,Dzau V

更新日期：2007-01-30 00:00:00

abstract：:Aerobic glycolysis in yeast and cancer cells produces pyruvate beyond oxidative needs, a paradox noted by Warburg almost a century ago. To address this question, we reanalyzed extensive measurements from (13)C magnetic resonance spectroscopy of yeast glycolysis and the coupled pathways of futile cycling and glycogen a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shulman RG,Rothman DL

更新日期：2015-09-01 00:00:00

abstract：:Studies were undertaken to determine the applicability and effectiveness of immunoadsorption chromatography on anti-low density lipoprotein (LDL) columns as a plasma-cholesterol-lowering procedure. Mass production and isolation of monospecific antibodies against swine LDL (rho = 1.006-1.063 g/ml) was carried out by im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoffel W,Demant T

更新日期：1981-01-01 00:00:00

abstract：:The lineage-determining transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is required for myeloid differentiation. Decreased function or expression of C/EBPalpha is often found in human acute myeloid leukemia. However, the precise impact of C/EBPalpha deficiency on the maturation arrest in leukemo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner K,Zhang P,Rosenbauer F,Drescher B,Kobayashi S,Radomska HS,Kutok JL,Gilliland DG,Krauter J,Tenen DG

更新日期：2006-04-18 00:00:00

abstract：:Nucleotide excision repair proteins have been implicated in genetic recombination by experiments in Saccharomyces cerevisiae and Drosophila melanogaster, but their role, if any, in mammalian cells is undefined. To investigate the role of the nucleotide excision repair gene ERCC1, the hamster homologue to the S. cerevi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sargent RG,Rolig RL,Kilburn AE,Adair GM,Wilson JH,Nairn RS

更新日期：1997-11-25 00:00:00

abstract：:Protein tyrosine phosphorylation and dephosphorylation are key regulatory events in T-cell receptor (TCR) signaling. We investigated the role of the tyrosine phosphatase SHPTP1 in TCR signaling by analysis of TCR signal transduction in motheaten (me/me) mice, which lack SHPTP1 expression. As revealed by flow cytometri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorenz U,Ravichandran KS,Burakoff SJ,Neel BG

更新日期：1996-09-03 00:00:00

abstract：:Performance on the visual paired-comparison task depends on the integrity of the hippocampal formation in humans, monkeys, and, for an analogous task, in rats. The present study sought additional evidence in healthy volunteers concerning the nature of this task. We found that performance on the visual paired-compariso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manns JR,Stark CE,Squire LR

更新日期：2000-10-24 00:00:00

abstract：:The ability to intercept uncooperative targets is key to many diverse flight behaviors, from courtship to predation. Previous research has looked for simple geometric rules describing the attack trajectories of animals, but the underlying feedback laws have remained obscure. Here, we use GPS loggers and onboard video ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brighton CH,Thomas ALR,Taylor GK

更新日期：2017-12-19 00:00:00

abstract：:Twenty-four hours after rats receive choline chloride (20 mmol/kg, by stomach tube) the activity of tyrosine hydroxylase [tyrosine 3-monooxygenase; L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] increases by 31% within adrenomedullary chromaffin cells. This treatment also causes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulus IH,Hirsch MJ,Wurtman RJ

更新日期：1977-02-01 00:00:00

abstract：:The immune defense against viral infections involves cytotoxic T lymphocytes that recognize viral products in the context of class I major histocompatibility complex (MHC) antigens. To evade such immune surveillance viruses may have evolved various strategies to manipulate the expression of class I antigens. Adenoviru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pääbo S,Nilsson T,Peterson PA

更新日期：1986-12-01 00:00:00

abstract：:In pulmonary arterial hypertension (PAH), antiapoptotic, proliferative, and inflammatory diatheses converge to create an obstructive vasculopathy. A selective down-regulation of the Kv channel Kv1.5 has been described in human and animal PAH. The resultant increase in intracellular free Ca(2+) ([Ca(2+)](i)) and K(+) (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnet S,Rochefort G,Sutendra G,Archer SL,Haromy A,Webster L,Hashimoto K,Bonnet SN,Michelakis ED

更新日期：2007-07-03 00:00:00

abstract：:We extend and apply theories of filled foam elasticity and failure to recently available data on foods. The predictions of elastic modulus and failure mode dependence on internal pressure and on wall integrity are borne out by photographic evidence of distortion and failure under compressive loading and under the loca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner M,Thiel BL,Donald AM

更新日期：2000-02-15 00:00:00

abstract：:We have characterized seven murine retinoic acid receptor gamma cDNA isoforms (mRAR-gamma 1 to -gamma 7) generated by alternative splicing of at least seven exons. These isoforms differ from one another in their 5' untranslated region and in two cases (mRAR-gamma 1 and -gamma 2) differ in their N-terminal A region, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kastner P,Krust A,Mendelsohn C,Garnier JM,Zelent A,Leroy P,Staub A,Chambon P

更新日期：1990-04-01 00:00:00

abstract：:To explore protein space from a global perspective, we consider 9,710 SCOP (Structural Classification of Proteins) domains with up to 70% sequence identity and present all similarities among them as networks: In the "domain network," nodes represent domains, and edges connect domains that share "motifs," i.e., signifi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nepomnyachiy S,Ben-Tal N,Kolodny R

更新日期：2014-08-12 00:00:00

abstract：:We report the presence of protein kinase C (PKC) in ejaculated human sperm as revealed by enzymatic activity assay and indirect immunohistochemistry. PKC is localized in the equatorial segment and in the principal piece of the tail. Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotem R,Paz GF,Homonnai ZT,Kalina M,Naor Z

更新日期：1990-09-01 00:00:00

abstract：:We and others have reported that the vast majority of virus-producing CD4(+) T cells during the acute infection of rhesus macaques with simian immunodeficiency virus (SIV) or CXCR4 (X4)-using simian/human immunodeficiency viruses (SHIVs) exhibited a nonactivated phenotype. These findings have been extended to show tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishimura Y,Sadjadpour R,Mattapallil JJ,Igarashi T,Lee W,Buckler-White A,Roederer M,Chun TW,Martin MA

更新日期：2009-05-12 00:00:00

abstract：:Gastrin-releasing peptide (GRP) is a 27-amino acid neuroendocrine hormone that may play a role in the pathophysiology of small cell lung carcinoma. GRP and bombesin, a structurally related peptide, stimulate the growth of some cultured cell types. C-terminal GRP peptide analogs were developed that inhibited 6 nM bombe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leban JJ,Kull FC Jr,Landavazo A,Stockstill B,McDermed JD

更新日期：1993-03-01 00:00:00

abstract：:Two issues long debated among Pacific and American prehistorians are (i) whether there was a pre-Columbian introduction of chicken (Gallus gallus) to the Americas and (ii) whether Polynesian contact with South America might be identified archaeologically, through the recovery of remains of unquestionable Polynesian or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Storey AA,Ramírez JM,Quiroz D,Burley DV,Addison DJ,Walter R,Anderson AJ,Hunt TL,Athens JS,Huynen L,Matisoo-Smith EA

更新日期：2007-06-19 00:00:00

abstract：:Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-linked ubiquitylation is known to regulate proteasome-independent events such as signal transduction, but its function in the context of heterogeneous ubiquitin chains remains unclear. Here, we report that K63 ubiquitylatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohtake F,Tsuchiya H,Saeki Y,Tanaka K

更新日期：2018-02-13 00:00:00

abstract：:Activation energies for the individual steps of secretory and viral fusion are reported to be large [Oberhauser, A. F., Monck, J. R. & Fernandez, J. M. (1992) Biophys. J. 61, 800-809; Clague, M. J., Schoch, C., Zech, L. & Blumenthal, R. (1990) Biochemistry 29, 1303-1308]. Understanding the cause for these large activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee J,Lentz BR

更新日期：1998-08-04 00:00:00

abstract：:Structural differences between dynein and kinesin suggest a unique molecular mechanism of dynein motility. Measuring the mechanical properties of a single molecule of dynein is crucial for revealing the mechanisms underlying its movement. We measured the step size and force produced by single molecules of active cytop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toba S,Watanabe TM,Yamaguchi-Okimoto L,Toyoshima YY,Higuchi H

更新日期：2006-04-11 00:00:00