Representation of stable social dominance relations by human infants.

abstract：:The matrix-2 (M2) protein from influenza A virus is a tetrameric, integral transmembrane (TM) protein that plays a vital role in viral replication by proton flux into the virus. The His37 tetrad is a pH sensor in the center of the M2 TM helix that activates the channel in response to the low endosomal pH. M2 consists ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torabifard H,Panahi A,Brooks CL 3rd

更新日期：2020-02-18 00:00:00

abstract：:To determine whether bacterial ribosomes recognize a distinguishing feature in the immediate vicinity of actual initiator codons or are directed to these sites through involvement of other portion(s) of the mRNA molecule, the interaction between ribosomes and defined (32)P-labeled initiator fragments from R17 RNA was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steitz JA

更新日期：1973-09-01 00:00:00

abstract：:Time courses of 13C labeling from alanine and ethanol in perfused mouse livers have been followed by NMR. The enrichment at specific carbons of glucose, glutamate, glutamine, aspartate, acetate, acetoacetate, beta-hydroxybutyrate, and lactate has been measured. The specific labeling of glutamate in the presence of lab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen SM,Shulman RG,McLaughlin AC

更新日期：1979-10-01 00:00:00

abstract：:DEAD-box RNA helicase proteins use the energy of ATP hydrolysis to drive the unwinding of duplex RNA. However, the mechanism that couples ATP utilization to duplex RNA unwinding is unknown. We measured ATP utilization and duplex RNA unwinding by DbpA, a non-processive bacterial DEAD-box RNA helicase specifically activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henn A,Cao W,Licciardello N,Heitkamp SE,Hackney DD,De La Cruz EM

更新日期：2010-03-02 00:00:00

abstract：:Interindividual differences in hepatic metabolism, which are mainly due to genetic polymorphism in its gene, have a large influence on individual drug efficacy and adverse reaction. Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells have the potential to predict interindividual...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takayama K,Morisaki Y,Kuno S,Nagamoto Y,Harada K,Furukawa N,Ohtaka M,Nishimura K,Imagawa K,Sakurai F,Tachibana M,Sumazaki R,Noguchi E,Nakanishi M,Hirata K,Kawabata K,Mizuguchi H

更新日期：2014-11-25 00:00:00

abstract：:Overexpression of the Gossypium hirsutum sucrose synthase (SuSy) gene under the control of 2 promoters was examined in hybrid poplar (Populus alba x grandidentata). Analysis of RNA transcript abundance, enzyme activity, cell wall composition, and soluble carbohydrates revealed significant changes in the transgenic lin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman HD,Yan J,Mansfield SD

更新日期：2009-08-04 00:00:00

abstract：:Adult naive T cells, which are at rest in normal conditions, proliferate strongly when transferred to lymphopenic hosts. In neonates, the first mature thymocytes to migrate to the periphery reach a compartment devoid of preexisting T cells. We have extensively analyzed the proliferation rate and phenotype of periphera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Campion A,Bourgeois C,Lambolez F,Martin B,Léaument S,Dautigny N,Tanchot C,Pénit C,Lucas B

更新日期：2002-04-02 00:00:00

abstract：:The template-directed synthesis of a bistable donor-acceptor [2]catenane wherein both translational isomers--one in which a tetrathiafulvalene unit in a mechanically interlocked crown ether occupies the cavity of a cyclobis(paraquat-p-phenylene) ring and the other in which a 1,5-dioxynaphthalene unit in the crown ethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Olson MA,Fang L,Benítez D,Tkatchouk E,Basu S,Basuray AN,Zhang D,Zhu D,Goddard WA,Stoddart JF

更新日期：2010-08-10 00:00:00

abstract：:The genes for platelet-derived growth factor (PDGF) A chain, B chain/c-sis, and the PDGF receptor are expressed in human malignant glioma cell lines. In the present investigation we have studied the expression of these genes in biopsy specimens from human glioblastomas. Hyperplasia of the vascular endothelium is a pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermansson M,Nistér M,Betsholtz C,Heldin CH,Westermark B,Funa K

更新日期：1988-10-01 00:00:00

abstract：:Selective culling in populations of most organisms is rank-order: individuals of low rank on a scale of potential fitnesses tend to be eliminated during early development, whereas surviving adults (whose number reflects the carrying capacity of the environment) are generally drawn from the distribution's upper end. Ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallace B

更新日期：1989-03-01 00:00:00

abstract：:A transient transfection assay using Drosophila S2 tissue culture cells and WT and mutant Drosophila vnd/NK-2 homeobox cDNAs was used to localize repression and activation domains of vnd/NK-2 homeodomain protein. A repression domain was identified near the N terminus of vnd/NK-2 homeodomain protein (amino acid residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stepchenko A,Nirenberg M

更新日期：2004-09-07 00:00:00

abstract：:Complete inactivation of the human retinoblastoma gene (RB) is believed to be an essential step in tumorigenesis of several different cancers. To provide a framework for understanding inactivation mechanisms, the structure of RB was delineated. The RB transcript is encoded in 27 exons dispersed over about 200 kilobase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong FD,Huang HJ,To H,Young LJ,Oro A,Bookstein R,Lee EY,Lee WH

更新日期：1989-07-01 00:00:00

abstract：:The activity-regulated cytoskeleton-associated protein (Arc) gene is a neural immediate early gene that is involved in synaptic downscaling and is robustly induced by prolonged wakefulness in rodent brains. Converging evidence has led to the hypothesis that wakefulness potentiates, and sleep reduces, synaptic strength...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki A,Yanagisawa M,Greene RW

更新日期：2020-05-12 00:00:00

abstract：:O(6)-methylguanine (O(6)meG) and related modifications of guanine in double-stranded DNA are functionally severe lesions that can be produced by many alkylating agents, including N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a potent carcinogen. O(6)meG is repaired through its demethylation by the O(6)-alkylguanine-DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang CS,Shemorry A,Varshavsky A

更新日期：2009-02-17 00:00:00

abstract：:Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miao RQ,Gao Y,Harrison KD,Prendergast J,Acevedo LM,Yu J,Hu F,Strittmatter SM,Sessa WC

更新日期：2006-07-18 00:00:00

abstract：:The anticonvulsants phenytoin and carbamazepine interact allosterically with the batrachotoxin binding site of sodium channels. In the present study, we demonstrate an autoradiographic technique to localize the batrachotoxin binding site on sodium channels in rat brain using [3H]batrachotoxinin-A 20-alpha-benzoate (BT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Worley PF,Baraban JM

更新日期：1987-05-01 00:00:00

abstract：:Steroidogenic factor-1 (SF-1) and liver receptor homologue-1 (LRH-1) belong to the fushi tarazu factor 1 subfamily of nuclear receptors. SF-1 is an essential factor for sex determination during development and regulates adrenal and gonadal steroidogenesis in the adult, whereas LRH-1 is a critical factor for developmen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang W,Zhang C,Marimuthu A,Krupka HI,Tabrizizad M,Shelloe R,Mehra U,Eng K,Nguyen H,Settachatgul C,Powell B,Milburn MV,West BL

更新日期：2005-05-24 00:00:00

abstract：:Maintaining a fleet of buses to transport students to school is a major expense for school districts. To reduce costs by reusing buses between schools, many districts spread start times across the morning. However, assigning each school a time involves estimating the impact on transportation costs and reconciling addi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bertsimas D,Delarue A,Martin S

更新日期：2019-03-26 00:00:00

abstract：:A cyclic hexapeptide, cyclo(Pro-Gly-Pro-Gly-Pro-Gly), has been synthesized; its solution conformations were examined by 220-MHz nuclear magnetic resonance spectroscopy. The solution structures have been deduced, and shown to vary as a function of solvent polarity. In addition, it has been found that this cyclic peptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deber CM,Torchia DA,Wong SC,Blout ER

更新日期：1972-07-01 00:00:00

abstract：:Interleukin 1 (IL-1) is a two-member family of proteins (IL-1 alpha and IL-1 beta) that mediates a diverse series of immune and inflammatory responses. These two proteins have only 26% amino acid homology yet bind to the same receptor. It is of importance to define the active sites of these molecules in order to under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosley B,Dower SK,Gillis S,Cosman D

更新日期：1987-07-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a potent inducer of differentiation of osteoblasts both in vivo and in vitro. We examined the action of BMP-2 on expression of a helix-loop-helix-type transcription factor, Id (inhibitor of differentiation), in osteoblast-like cells, as well as in osteoblast-enriched cells and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogata T,Wozney JM,Benezra R,Noda M

更新日期：1993-10-01 00:00:00

abstract：:Originally identified as an essential component of the herpes simplex virus immediate early (IE) gene enhancer complex, the transcriptional coactivator host cell factor-1 (HCF-1) has been implicated in a broad range of cellular regulatory circuits. The protein mediates activation through multiple interactions with tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narayanan A,Ruyechan WT,Kristie TM

更新日期：2007-06-26 00:00:00

abstract：:Pokeweed antiviral protein (PAP), a 29-kDa protein isolated from Phytolacca americana, inhibits translation by catalytically removing a specific adenine residue from the large rRNA of the 60S subunit of eukaryotic ribosomes. In addition to its ribosome-inactivating ability, PAP has potent antiviral activity against ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tumer NE,Hwang DJ,Bonness M

更新日期：1997-04-15 00:00:00

abstract：:The maspin protein has tumor suppressor activity in breast and prostate cancers. It inhibits cell motility and invasion in vitro and tumor growth and metastasis in nude mice. Maspin is structurally a member of the serpin (serine protease inhibitors) superfamily but deviates somewhat from classical serpins. We find tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng S,Truong B,Fredrickson D,Wu R,Pardee AB,Sager R

更新日期：1998-01-20 00:00:00

abstract：:The photoaffinity herbicide azidoatrazine (2-azido-4-ethylamino-6-isopropylamino-s-triazine) selectively labels the L subunit of the reaction center of the photosynthetic bacterium Rhodopseudomonas sphaeroides. Herbicide-resistant mutants retain the L subunit and have altered binding properties for methylthio- and chl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown AE,Gilbert CW,Guy R,Arntzen CJ

更新日期：1984-10-01 00:00:00

abstract：:Gating currents of the cloned delayed-rectifier K+ channel DRK1 expressed in Xenopus oocytes were measured with the open-oocyte Vaseline-gap voltage-clamp technique. DRK1 gating charge had the following salient properties: (i) gating-charge amplitude correlated positively with size of the expressed ionic K+ currents; ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taglialatela M,Stefani E

更新日期：1993-05-15 00:00:00

abstract：:Mutations in the thyroid hormone receptor α 1 gene (THRA) have recently been identified as a cause of intellectual deficit in humans. Patients present with structural abnormalities including microencephaly, reduced cerebellar volume and decreased axonal density. Here, we show that directed differentiation of THRA muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krieger TG,Moran CM,Frangini A,Visser WE,Schoenmakers E,Muntoni F,Clark CA,Gadian D,Chong WK,Kuczynski A,Dattani M,Lyons G,Efthymiadou A,Varga-Khadem F,Simons BD,Chatterjee K,Livesey FJ

更新日期：2019-11-05 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is an autosomal recessive phenotype consistent with impaired transport of cationic amino acids at the basolateral membrane of intestinal and renal epithelia. On the assumption that the basolateral membrane of epithelial cells and plasma membrane of parenchymal cells are functional a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DW,Scriver CR,Tenenhouse HS,Simell O

更新日期：1987-11-01 00:00:00

abstract：:Although nanoparticle-protein conjugates have been synthesized for numerous applications, bioconjugation remains a challenge, often resulting in denaturation or loss of protein function. This is partly because the protein-nanoparticle interface is poorly understood, which impedes the use of nanoparticles in nanomedici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aubin-Tam ME,Hwang W,Hamad-Schifferli K

更新日期：2009-03-17 00:00:00

abstract：:Drug resistance testing has been shown to be beneficial for clinical management of HIV type 1 infected patients. Whereas phenotypic assays directly measure drug resistance, the commonly used genotypic assays provide only indirect evidence of drug resistance, the major challenge being the interpretation of the sequence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beerenwinkel N,Schmidt B,Walter H,Kaiser R,Lengauer T,Hoffmann D,Korn K,Selbig J

更新日期：2002-06-11 00:00:00