Abstract：
:In this study, the effect of aucubin on H(2)O(2)-induced apoptosis was studied by using a rat pheochromocytoma (PC12) cell line. We have analyzed the apoptosis of H(2)O(2)-induced PC12 cells, H(2)O(2)-induced apoptosis appeared to correlate with lower Bcl-2 expression, higher Bax expression and sequential activation of caspase-3 leading to cleavage of poly-ADP-ribose polymerase (PARP). Aucubin not only inhibited lower Bcl-2 expression, high Bax expression, but also modulated caspase-3 activation, PARP cleavage, and eventually protected against H(2)O(2)-induced apoptosis. These results indicated that aucubin can obstruct H(2)O(2)-induced apoptosis by regulating of the expression of Bcl-2 and Bax, as well as suppression of caspases cascade activation.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Xue HY,Niu DY,Gao GZ,Lin QY,Jin LJ,Xu YPdoi
10.1007/s11033-010-0466-7subject
Has Abstractpub_date
2011-06-01 00:00:00pages
3561-7issue
5eissn
0301-4851issn
1573-4978journal_volume
38pub_type
杂志文章abstract：:Using a membrane filter retention technique we have studied the interaction between DNA and lysine rich histone H5 in vitro. It is found that, depending on the ionic conditions, H5 can bind DNA in a random or cooperative manner and exhibits a preference to DNA with high molecular weight and/or high A + T content, as a...
journal_title：Molecular biology reports
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