The regulation of TACE catalytic function by its prodomain.

abstract：:We report here a cDNA and its deduced amino acid sequence encoding a cathepsin D-like, aspartic protease from Chlamys farreri (denoted as CfCD) by expressed sequence tag and rapid amplification of cDNA ends techniques. The cDNA of CfCD consisted of 1,810 nucleotides with a canonical polyadenylation signal sequence AAT...

journal_title：Molecular biology reports

authors： Li C,Zhang H,Li L,Song L

更新日期：2010-03-01 00:00:00

abstract：:Stable inheritance and expression of transgene are important parameters for successful use of a transgenic crop. We previously transformed a Bt cry1Ba3 gene into cabbage inbred line CA21-3. To evaluate the stability of our Bt cabbage lineages, transgene inheritance and expression were examined in four successive gener...

journal_title：Molecular biology reports

authors： Yi DX,Fang ZY,Yang LM

更新日期：2020-04-01 00:00:00

abstract：:The new transcriptomes provided comprehensive sequence profiling data of transcriptomic variation during vernalization in Lily Asiatic Hybrids 'Tiny ghost'. A number of 52,277,184 sequencing raw reads totaling 5.11 Gbp of the chilling treatment (4 °C) sample and 39,466,176 sequencing raw reads totaling 3.85 Gbp of roo...

journal_title：Molecular biology reports

authors： Huang J,Liu X,Wang J,Lü Y

更新日期：2014-06-01 00:00:00

abstract：:Infection with mycobacterium tuberculosis (MTB) can cause different outcomes in hosts with variant genetic backgrounds. Previously, we identified an intracellular pathogen resistance 1 (Ipr1) gene with the role of resistance of MTB infection in mice model. However, until now, its binding proteins have been little know...

journal_title：Molecular biology reports

authors： Cai L,Pan H,Trzciński K,Thompson CM,Wu Q,Kramnik I

更新日期：2010-12-01 00:00:00

abstract：:Olanzapine, an atypical antipsychotic medication, has been associated with weight gain and metabolic toxicity, especially in long term usage. Carnosic acid (CA), a major constituent of rosemary extract, has been shown to improve metabolic abnormalities. In this experiment, the effect of CA on olanzapine-induced obesit...

journal_title：Molecular biology reports

authors： Razavi BM,Abazari AR,Rameshrad M,Hosseinzadeh H

更新日期：2020-10-01 00:00:00

abstract：:Through the process of alternative splicing, proteins with distinct biological functions and localisations are generated from a single gene. The mitochondrial folate metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) has been receiving attention in recent years as one of the most frequently upregulat...

journal_title：Molecular biology reports

authors： Nicolaidou V,Papaneophytou C,Koufaris C

更新日期：2020-09-01 00:00:00

abstract：:Eukaryotic 20S proteasomes are complex oligomeric proteins. The maturation process of the 14 different alpha- and beta-subunits has to occur in a highly coordinate manner. In addition beta-subunits are synthesized as proproteins and correct processing has to be guaranteed during complex maturation. The structure forma...

journal_title：Molecular biology reports

authors： Schmidt M,Schmidtke G,Kloetzel PM

更新日期：1997-03-01 00:00:00

abstract：:As a kind of binding protein, the type 1 Na(+)/H(+) exchanger (NHE1) is a receptor for the highly pathogenic Avian leukosis viruses-J subgroup (ALV-J) in chicken. In order to investigate the potential effect of chicken NHE1 gene on leukosis, we compared its expression between ALV-J-affected and -unaffected chicken, sc...

journal_title：Molecular biology reports

authors： Chen B,Pan W,Zhang L,Liu J,Ouyang H,Nie Q,Zhang X

更新日期：2014-10-01 00:00:00

abstract：:The RNA-binding protein Arabidopsis thaliana glycine-rich RNA-binding protein 7 (AtGRP7) regulates the steady-state abundance of numerous target transcripts in A. thaliana. Here we show that the GA1 and GA2 transcripts encoding the first enzymes of the gibberellin biosynthetic pathway are expressed at reduced levels i...

journal_title：Molecular biology reports

authors： Löhr B,Streitner C,Steffen A,Lange T,Staiger D

更新日期：2014-01-01 00:00:00

abstract：:Proto-oncogen Ahi-1 is closely related to a lot of human and mouse diseases. Ahi-1 mutation will lead to leukemia in mice and Joubert syndrome in human beings. We have cloned the full cDNA sequence of Ahi-1 homologous in zebrafish, and RT-PCR results of ZAhi-1 in different tissues reveal that ZAhi-1 expressed highest ...

journal_title：Molecular biology reports

authors： Zhou W,Song P

更新日期：2006-06-01 00:00:00

abstract：:The Pro12Ala and C161T polymorphisms in peroxisome proliferator-activated receptor γ (PPARγ) have been shown to be associated with carotid artery atherosclerosis. It remains unclear whether these two polymorphisms are associated with risk factors for cardiovascular disease (CVD) in hemodialysis (HD) patients. Therefor...

journal_title：Molecular biology reports

authors： Liu F,Mei X,Zhang Y,Qi H,Wang J,Wang Y,Jiang W,Zhang X,Yan H,Zhuang S

更新日期：2014-11-01 00:00:00

abstract：:Circulating long noncoding RNAs as biomarkers of diseases have attracted increasing attention recently. However, circulating lncRNAs in hypertension is still unexplored niche. The levels of lncRNAs GAS5, NR024118, MRAK134679, AX765700 and MRNR026574 were measured in the serum and myocardium of hypertensive rats and no...

journal_title：Molecular biology reports

authors： Wu Y,Zhang Z,Ren S,Li K,Ning Q,Jiang X

更新日期：2019-12-01 00:00:00

abstract：:We have cloned two full-length cDNAs from two ferritin genes (Aifer1 and Aifer2) of the bay scallop, Argopecten irradians (Lamarck 1819). The cDNAs are 1,019 and 827 bp in length and encode proteins of 171 and 173 amino acids, respectively. The 5' UTR of each contains a conserved iron response element (IRE) motif. Seq...

journal_title：Molecular biology reports

authors： He X,Zhang Y,Wu X,Xiao S,Yu Z

更新日期：2011-03-01 00:00:00

abstract：:Combined treatment with niacin and chromium has been found to have a protective effect against oxidative damage to different tissues of hyperlipidemic rats. But its effects on vascular endothelial dysfunction are less clear. This study was performed to investigate the effect of combined treatment with niacin and chrom...

journal_title：Molecular biology reports

authors： Niu N,Yu YH,Wang Y,Wang LJ,Li Q,Guo LM

更新日期：2009-07-01 00:00:00

abstract：:Prkar1b gene encodes regulatory type I, beta subunit (RIβ) of cAMP dependent protein kinase A in mouse. Among the various isoforms of regulatory and catalytic subunits that comprise mammalian PKA, RIβ subunit is considered to be one of the important subunits for neuronal functions. This is involved in multiple forms o...

journal_title：Molecular biology reports

authors： Banday AR,Azim S,Tabish M

更新日期：2012-04-01 00:00:00

abstract：:A nucleic acid sequence MC, encoding Momordica Chanrantia anti-hyperglycaemic peptide MC6 (accession: AAX06814) synthesized according to Escherichia coli preferred codons, was cloned and expressed in E. coli. Recombinant protein pQE8-MC (about 3.5 kDa) was purified and analyzed by 20% SDS-PAGE and western blot. It rev...

journal_title：Molecular biology reports

authors： Liu SX,Fu ZP,Mu RM,Hu ZB,Wang FJ,Wang XR

更新日期：2010-04-01 00:00:00

abstract：:The oligochaete earthworm, Eudrilus eugeniae is capable of regenerating both anterior and posterior segments. The present study focuses on the transcriptome analysis of earthworm E. eugeniae to identify and functionally annotate the key genes supporting the anterior blastema formation and regulating the anterior regen...

journal_title：Molecular biology reports

authors： Paul S,Balakrishnan S,Arumugaperumal A,Lathakumari S,Syamala SS,Arumugaswami V,Sivasubramaniam S

更新日期：2020-12-11 00:00:00

abstract：:Hypertension is the most widespread disease in the world affecting humans and imparts a significant cardiovascular and renal risk to patients, and extensive research over the past few decades has enhanced our understanding of the underlying pathogenesis of hypertension. A growing number of studies have shown that miRN...

journal_title：Molecular biology reports

authors： Miao C,Chang J,Zhang G

更新日期：2018-12-01 00:00:00

abstract：:MAPK cascade is an important intracellular signaling module and function as a convergent point for crosstalk during abiotic stress signaling. In this study SbMAPKK gene has been isolated from Salicornia brachiata, a highly salt tolerant plant growing in costal marshes of Gujarat, India. The SbMAPKK gene is 1,023 bp lo...

journal_title：Molecular biology reports

authors： Agarwal PK,Gupta K,Jha B

更新日期：2010-02-01 00:00:00

abstract：:Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (...

journal_title：Molecular biology reports

authors： Corso CR,Stipp MC,Adami ER,da Silva LM,Mariott M,de Andrade SF,de Souza Ramos EA,Klassen G,Beltrame OC,Queiroz-Telles JE,de Oliveira CS,Stefanello MÉA,Acco A

更新日期：2019-10-01 00:00:00

abstract：:Familial Mediterranean fever is an autosomal recessive disorder characterized by recurrent attacks of abdominal pain, synovitis and pleuritis. MEFV gene mutations are responsible for the disease. The objective of this study was to identify the frequency and distribution of 12 MEFV mutations in 153 Syrian patients and ...

journal_title：Molecular biology reports

authors： Jarjour RA

更新日期：2010-01-01 00:00:00

abstract：:The CRISPR/Cas9 system now allows for unprecedented possibilities of genome editing. However, there are some limitations, including achieving efficient one-step multiple genome targeting to save costs, time, and ensure high quality. In the present study, we investigated the efficiency of one-step multiple gene modific...

journal_title：Molecular biology reports

authors： Hirata M,Wittayarat M,Namula Z,Le QA,Lin Q,Nguyen NT,Takebayashi K,Sato Y,Tanihara F,Otoi T

更新日期：2020-07-01 00:00:00

abstract：:Transcriptional factors are the major regulators of plant signaling pathways in response to environmental stresses i.e., drought, salinity and cold. Hereby, the GhMYB108-like was characterized to determine whether it regulate these stresses. The GhMYB108-like cDNA consisted of 1107 base pairs (bp) with 807 open readin...

journal_title：Molecular biology reports

authors： Ullah A,Ul Qamar MT,Nisar M,Hazrat A,Rahim G,Khan AH,Hayat K,Ahmed S,Ali W,Khan A,Yang X

更新日期：2020-03-01 00:00:00

abstract：:The cell cycle is a complex and strictly controlled process, consisting of different phases. Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the dereg...

journal_title：Molecular biology reports

authors： Caglar HO,Biray Avci C

更新日期：2020-04-01 00:00:00

abstract：:We report the characterization of VvIAA9, an auxin/indole-3-acetic acid (Aux/IAA) protein, in grapevine (Vitis vinifera L.). VvIAA9 was expressed abundantly in leaves and berries. VvIAA9 transcription was drastically upregulated from anthesis to onset of ripening (termed véraison), in which berry diameter rapidly incr...

journal_title：Molecular biology reports

authors： Fujita K,Horiuchi H,Takato H,Kohno M,Suzuki S

更新日期：2012-07-01 00:00:00

abstract：:As-ClC (chloride channels protein from Artemia sinica), a member from the chloride channels protein family, is a α-helical membrane protein predicted to traverse the cell membrane 11 times. It is important for several physiological functions such as cell volume regulation, cell proliferation, growth and differentiatio...

journal_title：Molecular biology reports

authors： Zhang Q,Hou M,Li Q,Han L,Yuan Z,Tan J,Du B,Zou X,Hou L

更新日期：2013-05-01 00:00:00

abstract：:Using kinetics of approach to steady state labeling, we have found that liver poly(A)+ mRNAs fall into three populations, differing in stability and probably in processing, as reflected in their dissimilar delays in reaching polyribosomes and turnover times. There are mRNA-1 (delay 10 min, half-life 1 hr); mRNA-2(dela...

journal_title：Molecular biology reports

authors： Lubimova EV,Chernovskaja TV,Lerman MI

更新日期：1975-12-01 00:00:00

abstract：:Azotobacter chroococcum and A. salinestris do not possess significant and distinct morphological and physiological differences and are often mistaken with each other in microbiological research. In this study, 12 isolates of Azotobacter isolated by standard protocol from soils were identified morphologically and physi...

journal_title：Molecular biology reports

authors： Khosravi H,Dolatabad HK

更新日期：2020-01-01 00:00:00

abstract：:Human Papillomavirus infection is considered as the main etiological factor of cervical cancer (ICC), although, the role of host genetic factors in ICC susceptibility has been increasing. Immunological response is crucial for the prevention of viral associated diseases. Interleukin 1 receptor antagonist (IL-1RN) is co...

journal_title：Molecular biology reports

authors： Sousa H,Santos AM,Catarino R,Pinto D,Moutinho J,Canedo P,Machado JC,Medeiros R

更新日期：2012-12-01 00:00:00

abstract：:The widely studied candidate genes of the renin-angiotensin-aldosterone system, angiotensinogen (AGT), and angiotensin II receptor type 1 (AGTR1), are implicated in the development of diabetic nephropathy (DN). A number of studies have evaluated the association between the functional polymorphisms, AGT M235T and AGTR1...

journal_title：Molecular biology reports

authors： Ding W,Wang F,Fang Q,Zhang M,Chen J,Gu Y

更新日期：2012-02-01 00:00:00