The Staphylococcus aureus autoinducer-2 synthase LuxS is regulated by Ser/Thr phosphorylation.

Abstract:

:The Staphylococcus aureus autoinducer-2 (AI-2) producer protein LuxS is phosphorylated by the Ser/Thr kinase Stk1 at a unique position, Thr14. The enzymatic activity of the phosphorylated isoform of LuxS was abrogated compared to that of nonphosphorylated LuxS, thus providing the first evidence of an AI-2-producing enzyme regulated by phosphorylation and demonstrating that S. aureus possesses an original and specific system for controlling AI-2 synthesis.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Cluzel ME,Zanella-Cléon I,Cozzone AJ,Fütterer K,Duclos B,Molle V

doi

10.1128/JB.00853-10

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

6295-301

issue

23

eissn

0021-9193

issn

1098-5530

pii

JB.00853-10

journal_volume

192

pub_type

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