EspF of enteropathogenic Escherichia coli binds sorting nexin 9.

Abstract:

:EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and non-mitochondrial protein colocalization in infected epithelial cells.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Marchès O,Batchelor M,Shaw RK,Patel A,Cummings N,Nagai T,Sasakawa C,Carlsson SR,Lundmark R,Cougoule C,Caron E,Knutton S,Connerton I,Frankel G

doi

10.1128/JB.188.8.3110-3115.2006

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

3110-5

issue

8

eissn

0021-9193

issn

1098-5530

pii

188/8/3110

journal_volume

188

pub_type

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