Abstract:
:An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging.
journal_name
Contrast Media Mol Imagingjournal_title
Contrast media & molecular imagingauthors
van Schooneveld MM,Cormode DP,Koole R,van Wijngaarden JT,Calcagno C,Skajaa T,Hilhorst J,'t Hart DC,Fayad ZA,Mulder WJ,Meijerink Adoi
10.1002/cmmi.376subject
Has Abstractpub_date
2010-07-01 00:00:00pages
231-6issue
4eissn
1555-4309issn
1555-4317journal_volume
5pub_type
杂志文章abstract::Quantum dot micelles (pQDs) with a paramagnetic coating are promising nanoparticles for bimodal molecular imaging. Their bright fluorescence allows for optical detection, while their Gd payload enables visualization with contrast-enhanced MRI. A popular approach in molecular MRI is the targeting of abundantly expresse...
journal_title:Contrast media & molecular imaging
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abstract::Perfluorocarbon (PFC) double emulsions loaded with a water-soluble, therapeutic agent can be triggered by ultrasound in a process known as acoustic droplet vaporization. Elucidating the stability and biodistribution of these sonosensitive vehicles and encapsulated agents is critical in developing targeted drug deliver...
journal_title:Contrast media & molecular imaging
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abstract::For in vivo applications of magnetically labeled stem cells, biological effects of the labeling procedure have to be precluded. This study evaluates the effect of different ferucarbotran cell labeling protocols on chondrogenic differentiation of human mesenchymal stem cells (hMSC) as well as their implications for MR ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.276
更新日期:2009-07-01 00:00:00
abstract::Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new metho...
journal_title:Contrast media & molecular imaging
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abstract::In the pursuit of understanding the pathological alterations that underlie ischaemic injuries, such as vascular remodelling and reorganisation, there is a need for recognising the capabilities and limitations of in vivo imaging techniques. Thus, this review presents contemporary published research of imaging modalitie...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1155/2019/3128529
更新日期:2019-02-03 00:00:00
abstract::The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research applications. In that context, a photoacoustic molecular probe based on ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
abstract::MRI cell tracking is a promising technique to track various cell types (stem cells, tumor cells, etc.) in living animals. Usually, cells are incubated with iron oxides (T(2) contrast agent) in order to take up the particles before being injected in vivo. Iron oxide quantification is important in such studies for valid...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.497
更新日期:2012-05-01 00:00:00
abstract:Objective:To qualitatively and quantitatively compare the contrast-enhanced magnetic resonance angiography (MRA) and magnetic resonance imaging (MRI) in one-stop shop of abdominal imaging with Gadobutrol and Gd-DTPA at equimolar doses of gadolinium. Materials and Methods:This was a prospective designed, multiple cente...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract::Spectral molecular imaging is a new X-ray-based imaging technology providing highly specific 3D imaging at high spatial resolution that has the potential to measure disease activity and response to treatment noninvasively. The ability to identify and quantify components of tissue and biomarkers of disease activity der...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1002/cmmi.1550
更新日期:2014-01-01 00:00:00
abstract::Melanoma is the most dangerous form of skin cancer and its incidence is rising each year. Because the current methods of diagnosis based on the visual aspect of the tumor show limitations, several new techniques are emerging to help in this diagnosis, amongst which are magnetic resonance imaging (MRI) and electron par...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1554
更新日期:2014-03-01 00:00:00
abstract::Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. These probes were based on the PLG*LWAR peptide sequence, known to be hydrolyzed between Gly and Leu by a broad panel of MMPs. A Gd-DOTA chelate was conjugated...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.478
更新日期:2012-03-01 00:00:00
abstract::Physicians and scientists use a broad spectrum of terms to classify contrast media (CM)-induced adverse reactions. In particular, the designation of hypersensitivity reactions is quite varied. Consequently, comparisons of different papers dealing with this subject are difficult or even impossible. Moreover, general de...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1475
更新日期:2012-11-01 00:00:00
abstract:Objectives:Bone ischemia and necrosis are challenging to treat, requiring investigation of native and engineered bone revascularisation processes through advanced imaging techniques. This study demonstrates an experimental two-step method for precise bone and vessel analysis in native bones or vascularised bone grafts ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2017/4035160
更新日期:2017-04-23 00:00:00
abstract::Self-aggregation of dyes even at low concentrations poses a considerable challenge in preparing sufficiently bright molecular probes for in vivo imaging, particularly in the conjugation of near infrared cyanine dyes to polypeptides with multiple labeling sites. Such self-aggregation leads to a significant energy trans...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1585
更新日期:2014-09-01 00:00:00
abstract::Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacter...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2018/2198703
更新日期:2018-07-11 00:00:00
abstract::Optical fluorescence imaging has been developed as an aid to intraoperative diagnosis to improve surgical and endoscopic procedures. Compared with other intraoperative imaging methods, it is lower in cost, has a high safety margin, is portable and easy to use. γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) is a ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1705
更新日期:2016-11-01 00:00:00
abstract::Developing agents with 'seek, treat and see' capability is critical for personalized molecular medicine. Those agents will specifically target the disease markers for diagnosis and apply the biologically effective dose for treatment. Retinoids regulate a multitude of biological processes. In addition, retinoic acid ca...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.419
更新日期:2011-07-01 00:00:00
abstract::The purpose was to investigate whether MnCl(2) can serve as an MRI contrast agent to detect chronic cryoinjury infarction in pigs in vivo and whether MnCl(2) causes significant hemodynamic disturbances. Hearts were subjected to a topical 2 min cryothermia to establish myocardial infarction (MI). Thereafter GdDTPA-enha...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.438
更新日期:2011-11-01 00:00:00
abstract::Ferrite nanoparticles (F-NPs) can transform both cancer diagnostics and therapeutics. Superparamagnetic F-NPs exhibit high magnetic moment and susceptibility such that in presence of a static magnetic field transverse relaxation rate of water protons for MRI contrast is augmented to locate F-NPs (i.e., diagnostics) an...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1155/2017/6387217
更新日期:2017-12-11 00:00:00
abstract::Barium sulfate and lead oxide contrast media are frequently used for cadaver-based angiography studies. These contrast media have not previously been compared to determine which is optimal for the visualisation and measurement of blood vessels. In this study, the lower limb vessels of 16 embalmed Wistar rats, and four...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1695
更新日期:2016-07-01 00:00:00
abstract:Rationale:To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods:195 patients with 44 different diseases have been included. Relatio...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2018/2601281
更新日期:2018-07-02 00:00:00
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journal_title:Contrast media & molecular imaging
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更新日期:2017-05-30 00:00:00
abstract::Chemical exchange saturation transfer (CEST) MRI is sensitive to dilute proteins and peptides as well as microenvironmental properties. However, the complexity of the CEST MRI effect, which varies with the labile proton content, exchange rate and experimental conditions, underscores the need for developing quantitativ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1569
更新日期:2014-07-01 00:00:00
abstract::A specific mouse whole body coil and a dedicated gradient system at 4.7 T were coupled with an ultra-fast 3D gradient echo MRI and keyhole reconstruction technique to obtain 3D whole-body dynamic T(1)-weighted or T(2)*-weighted imaging. The technique was used to visualize the real-time distribution of non-targeting T(...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.429
更新日期:2011-07-01 00:00:00
abstract::The aim of the present study was to test alginate gels of different compositions as a system for controlled release of manganese ions (Mn(2+)) for application in manganese-enhanced MRI (MEMRI), in order to circumvent the challenge of achieving optimal MRI resolution without resorting to high, potentially cytotoxic dos...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
abstract:Objective:The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (13C) metabolic imaging with [1-13C]-labeled pyruvate for evaluating real-time in vivo metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. Materials and Methods:3D 13C magnetic resonance sp...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2018/3215658
更新日期:2018-07-30 00:00:00
abstract::Stem cells, cancer cells and immune cells were labeled by co-incubation with a new ultra-small iron oxide nanoparticle called Molday ION Rhodamine-B (MIRB). Iron staining, fluorescence imaging, transmission electron microscopy and flow cytometry were used to assess cell viability, function and labeling efficiency. Thi...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.456
更新日期:2011-11-01 00:00:00
abstract::Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1002/cmmi.442
更新日期:2011-09-01 00:00:00
abstract::Red blood cells (RBCs) loaded with iron oxide nanoparticles have been proposed as biomimetic constructs with long half-life (ca. 20 days) in the blood compartment and potentially interesting properties (such as relaxivity) as intravascular contrast agents for magnetic resonance imaging. However, the encapsulation of n...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1562
更新日期:2014-05-01 00:00:00
abstract::Generally angiogenic factors induce the expression of E-selectin in vascular endothelial cells in the tumors. In this study, we employed an anti-E-selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visualize tumor regions. The anti-E-selectin antibody was conjugated on th...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.367
更新日期:2010-03-01 00:00:00