Abstract:
Rationale:To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods:195 patients with 44 different diseases have been included. Relationship between SUVmax, Clinical, pathological, and prognostic information has been analyzed. Results:Malignant tumors do not show higher SUVmax than benign ones (P=0.443). We divided all 44 different diseases into two groups; SUVmax of group 1 is significantly higher than group 2 (P ≤ 0.001). The ROC curve suggests 4.35 is the cutoff value to distinguish groups 1 and 2 (sensitivity = 0.789; specificity = 0.736). SUVmax correlates with Ki-67 index, mitotic count, vascular resection, histological grade, and recurrent STS without considering pathological diagnosis (P=0.001, P=0.012, P=0.002, P ≤ 0.001, and P=0.037, resp.). Conclusion:18F-FDG-PET/CT cannot simply distinguish malignant and benign tumors in retroperitoneal/intra-abdominal cavity; however, the SUVmax of malignant tumors, inflammatory pseudotumor, and PPGL group is higher than the SUVmax of benign tumors, lymph node metastasis, hematoma, and low malignant STS group. Guidance of "SUVmax location" may be helpful for biopsy and pathology dissection.
journal_name
Contrast Media Mol Imagingjournal_title
Contrast media & molecular imagingauthors
Liu DN,Li ZW,Wang HY,Zhao M,Zhao W,Hao CYdoi
10.1155/2018/2601281subject
Has Abstractpub_date
2018-07-02 00:00:00pages
2601281eissn
1555-4309issn
1555-4317journal_volume
2018pub_type
杂志文章abstract::Barium sulfate and lead oxide contrast media are frequently used for cadaver-based angiography studies. These contrast media have not previously been compared to determine which is optimal for the visualisation and measurement of blood vessels. In this study, the lower limb vessels of 16 embalmed Wistar rats, and four...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1695
更新日期:2016-07-01 00:00:00
abstract::Recent advances in artificial intelligence (AI) and deep learning (DL) have impacted many scientific fields including biomedical maging. Magnetic resonance imaging (MRI) is a well-established method in breast imaging with several indications including screening, staging, and therapy monitoring. The rapid development a...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1155/2020/6805710
更新日期:2020-08-28 00:00:00
abstract::We evaluated the difference in the status of dopamine transporters (DATs) depending on Parkinsonism, cerebellar, and autonomic features using F-18 FP-CIT positron emission tomography (PET) in multiple system atrophy with cerebellar ataxia (MSA-C). We also assessed whether the DAT PET could be useful in the management ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2017/8598705
更新日期:2017-11-29 00:00:00
abstract::Gold nanoparticles coated by gadolinium (III) chelates (Au@DTDTPA) where DTDTPA is a dithiolated bisamide derivative of diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), constituted contrast agents for both X-ray computed tomography and magnetic resonance imaging. In an MRI context, highly stable Gd(3+) compl...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1616
更新日期:2015-05-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/7368384.]. ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/2165693
更新日期:2018-08-23 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this pilot study was to establish the ability of dynamic contrast enhanced computed tomography (DCE-CT) to detect changes in tumor blood flow (BF) and oxygenation induced by vasoactive substances in rats. MATERIALS AND METHODS:Under ultrasound guidance, a fiber-optic probe was g...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.399
更新日期:2011-01-01 00:00:00
abstract::Perfluorocarbon (PFC) double emulsions loaded with a water-soluble, therapeutic agent can be triggered by ultrasound in a process known as acoustic droplet vaporization. Elucidating the stability and biodistribution of these sonosensitive vehicles and encapsulated agents is critical in developing targeted drug deliver...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1532
更新日期:2013-07-01 00:00:00
abstract:Objective:To qualitatively and quantitatively compare the contrast-enhanced magnetic resonance angiography (MRA) and magnetic resonance imaging (MRI) in one-stop shop of abdominal imaging with Gadobutrol and Gd-DTPA at equimolar doses of gadolinium. Materials and Methods:This was a prospective designed, multiple cente...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2019/9738464
更新日期:2019-12-02 00:00:00
abstract::A specific mouse whole body coil and a dedicated gradient system at 4.7 T were coupled with an ultra-fast 3D gradient echo MRI and keyhole reconstruction technique to obtain 3D whole-body dynamic T(1)-weighted or T(2)*-weighted imaging. The technique was used to visualize the real-time distribution of non-targeting T(...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.429
更新日期:2011-07-01 00:00:00
abstract::Carcinoma of the prostate is the most frequent diagnosed malignant tumor in men and is the second leading cause of cancer-related death in this group. The cure rate of prostate cancer is highly dependent on the stage of disease at the diagnosis and early detection is key to designing effective treatment strategies. Th...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1514
更新日期:2013-03-01 00:00:00
abstract::The aim of this work was to investigate the MRI findings on tumor xenografts induced in nude mice by the inoculation of human pancreatic cancer cells labeled with superparamagnetic iron oxide (SPIO), and to monitor the kinetics of SPIO distribution in tumor xenografts. The labeled cancer cells were subcutaneously inoc...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.465
更新日期:2012-01-01 00:00:00
abstract::Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of 99mTc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-99mTc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2020/2525037
更新日期:2020-04-27 00:00:00
abstract::Physicians and scientists use a broad spectrum of terms to classify contrast media (CM)-induced adverse reactions. In particular, the designation of hypersensitivity reactions is quite varied. Consequently, comparisons of different papers dealing with this subject are difficult or even impossible. Moreover, general de...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1475
更新日期:2012-11-01 00:00:00
abstract::Inorganic doping was used to create flexible, paramagnetic nanoparticle contrast agents for in vivo molecular magnetic resonance imaging (MRI) with low transverse relaxivity (r2). Most nanoparticle contrast agents formed from superparamagnetic metal oxides are developed with high r2. While sensitive, they can have lim...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1578
更新日期:2014-09-01 00:00:00
abstract::Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacter...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2018/2198703
更新日期:2018-07-11 00:00:00
abstract::A generic site-specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein-ligation capacity of the enzyme Sortase A to label camelid single-domain antibody-fragments, also known as nanobodies. The versatility...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1696
更新日期:2016-09-01 00:00:00
abstract::Glioblastoma (GBM) is the most common primary malignant type of brain neoplasm in adults and carries a dismal prognosis. The current standard of care for GBM is surgical excision followed by radiation therapy (RT) with concurrent and adjuvant temozolomide-based chemotherapy (TMZ) by six additional cycles. In addition,...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1155/2018/6828396
更新日期:2018-12-02 00:00:00
abstract::In this study we report the development of a bioconjugate between superparamagnetic iron oxide nanoparticles and Phl p5a (one of the major allergens from grass pollen). The bioconjugate also contains an optical probe (Alexa647) conjugated to the nanoparticle via biotin-streptavidin association. We show that this conju...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1466
更新日期:2012-07-01 00:00:00
abstract::Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared 68Ga-DOTA- and 18F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-S...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2017/7645070
更新日期:2017-12-31 00:00:00
abstract::Quantum dots (QDs) are fluorescent nanoparticles with broad excitation and narrow, wavelength-tunable emission spectra. They are used extensively for in vitro fluorescence imaging studies and more recently for in vivo small animal and pre-clinical studies. To date there has been little concern about the selection of Q...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.409
更新日期:2011-05-01 00:00:00
abstract::Purpose. To investigate the value of SUV metrics and radiomic features based on the ability of 18F-FDG PET/CT in differentiating between breast lymphoma and breast carcinoma. Methods. A total of 67 breast nodules from 44 patients who underwent 18F-FDG PET/CT pretreatment were retrospectively analyzed. Radiomic paramet...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2019/4507694
更新日期:2019-02-25 00:00:00
abstract::Knowledge of the longitudinal and transverse relaxation times (T(1) and T(2)) of water protons in an aqueous solution of an MRI contrast agent is essential for its characterization. These parameters can be measured at low field on low resolution spectrometers or at high field on high resolution spectrometers. The reli...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.294
更新日期:2009-11-01 00:00:00
abstract::A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.383
更新日期:2010-05-01 00:00:00
abstract::Quantum dot micelles (pQDs) with a paramagnetic coating are promising nanoparticles for bimodal molecular imaging. Their bright fluorescence allows for optical detection, while their Gd payload enables visualization with contrast-enhanced MRI. A popular approach in molecular MRI is the targeting of abundantly expresse...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.411
更新日期:2011-03-01 00:00:00
abstract::Various contrast agents (Magnevist, Gadovist and Multihance) loaded into polymeric nanocapsules were synthesized by the inverse miniemulsion technique. The relaxivity of the resultant contrast agents was assessed at 1.5 T magnetic field strength. The ionic relaxivity of the contrast agents could at least be maintained...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.364
更新日期:2010-03-01 00:00:00
abstract::An observational study was set up to assess the feasibility of [18F]FPRGD2 PET/CT for imaging patients with multiple myeloma (MM) and to compare its detection rate with low dose CT alone and combined [18F]NaF/[18F]FDG PET/CT images. Four patients (2 newly diagnosed patients and 2 with relapsed MM) were included and un...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2017/6162845
更新日期:2017-07-27 00:00:00
abstract::An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Altho...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.376
更新日期:2010-07-01 00:00:00
abstract::Self-aggregation of dyes even at low concentrations poses a considerable challenge in preparing sufficiently bright molecular probes for in vivo imaging, particularly in the conjugation of near infrared cyanine dyes to polypeptides with multiple labeling sites. Such self-aggregation leads to a significant energy trans...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1585
更新日期:2014-09-01 00:00:00
abstract::Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1002/cmmi.442
更新日期:2011-09-01 00:00:00
abstract::Stem cells, cancer cells and immune cells were labeled by co-incubation with a new ultra-small iron oxide nanoparticle called Molday ION Rhodamine-B (MIRB). Iron staining, fluorescence imaging, transmission electron microscopy and flow cytometry were used to assess cell viability, function and labeling efficiency. Thi...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.456
更新日期:2011-11-01 00:00:00