Surgical tissue handling methods to optimize ex vivo fluorescence with the activatable optical probe γ-glutamyl hydroxymethyl rhodamine green.

abstract：:Gold nanoparticles coated by gadolinium (III) chelates (Au@DTDTPA) where DTDTPA is a dithiolated bisamide derivative of diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), constituted contrast agents for both X-ray computed tomography and magnetic resonance imaging. In an MRI context, highly stable Gd(3+) compl...

journal_title：Contrast media & molecular imaging

authors： Mogilireddy V,Déchamps-Olivier I,Alric C,Laurent G,Laurent S,Vander Elst L,Muller R,Bazzi R,Roux S,Tillement O,Chuburu F

更新日期：2015-05-01 00:00:00

abstract：:Various studies have shown that various cell types can be labeled with iron oxide particles and visualized by magnetic resonance imaging (MRI). However, reported protocols for cell labeling show a large variation in terms of labeling dose and incubation time. It is therefore not clear how different labeling protocols ...

journal_title：Contrast media & molecular imaging

authors： van Tiel ST,Wielopolski PA,Houston GC,Krestin GP,Bernsen MR

更新日期：2010-09-01 00:00:00

abstract：:Knowledge of the longitudinal and transverse relaxation times (T(1) and T(2)) of water protons in an aqueous solution of an MRI contrast agent is essential for its characterization. These parameters can be measured at low field on low resolution spectrometers or at high field on high resolution spectrometers. The reli...

journal_title：Contrast media & molecular imaging

authors： Henoumont C,Laurent S,Vander Elst L

更新日期：2009-11-01 00:00:00

abstract：:Perfluorocarbon (PFC) double emulsions loaded with a water-soluble, therapeutic agent can be triggered by ultrasound in a process known as acoustic droplet vaporization. Elucidating the stability and biodistribution of these sonosensitive vehicles and encapsulated agents is critical in developing targeted drug deliver...

journal_title：Contrast media & molecular imaging

authors： Fabiilli ML,Piert MR,Koeppe RA,Sherman PS,Quesada CA,Kripfgans OD

更新日期：2013-07-01 00:00:00

abstract：:A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...

journal_title：Contrast media & molecular imaging

authors： Liu G,Gilad AA,Bulte JW,van Zijl PC,McMahon MT

更新日期：2010-05-01 00:00:00

abstract：:Glioblastoma (GBM) is the most common primary malignant type of brain neoplasm in adults and carries a dismal prognosis. The current standard of care for GBM is surgical excision followed by radiation therapy (RT) with concurrent and adjuvant temozolomide-based chemotherapy (TMZ) by six additional cycles. In addition,...

journal_title：Contrast media & molecular imaging

authors： Zikou A,Sioka C,Alexiou GA,Fotopoulos A,Voulgaris S,Argyropoulou MI

更新日期：2018-12-02 00:00:00

abstract：PURPOSE:Regional wall thickening measurement by delayed contrast MRI may assess myocardial viability and functional recovery of ischemic cardiomyopathy. MATERIALS AND METHODS:Delayed contrast MRI data was used in 40 patients with significant coronary artery disease and severe left ventricular dysfunction. Regional wal...

journal_title：Contrast media & molecular imaging

authors： Sharma R,Katz JK

更新日期：2009-01-01 00:00:00

abstract：:Various contrast agents (Magnevist, Gadovist and Multihance) loaded into polymeric nanocapsules were synthesized by the inverse miniemulsion technique. The relaxivity of the resultant contrast agents was assessed at 1.5 T magnetic field strength. The ionic relaxivity of the contrast agents could at least be maintained...

journal_title：Contrast media & molecular imaging

authors： Sharma S,Paiphansiri U,Hombach V,Mailänder V,Zimmermann O,Landfester K,Rasche V

更新日期：2010-03-01 00:00:00

abstract：:Self-aggregation of dyes even at low concentrations poses a considerable challenge in preparing sufficiently bright molecular probes for in vivo imaging, particularly in the conjugation of near infrared cyanine dyes to polypeptides with multiple labeling sites. Such self-aggregation leads to a significant energy trans...

journal_title：Contrast media & molecular imaging

authors： Zhegalova NG,He S,Zhou H,Kim DM,Berezin MY

更新日期：2014-09-01 00:00:00

abstract：:Developing agents with 'seek, treat and see' capability is critical for personalized molecular medicine. Those agents will specifically target the disease markers for diagnosis and apply the biologically effective dose for treatment. Retinoids regulate a multitude of biological processes. In addition, retinoic acid ca...

journal_title：Contrast media & molecular imaging

authors： Wang W,Qiu X,Zhang F,Sun J,Cameron AG,Wendt JA,Mawad ME,Ke S

更新日期：2011-07-01 00:00:00

abstract：:Ferrite nanoparticles (F-NPs) can transform both cancer diagnostics and therapeutics. Superparamagnetic F-NPs exhibit high magnetic moment and susceptibility such that in presence of a static magnetic field transverse relaxation rate of water protons for MRI contrast is augmented to locate F-NPs (i.e., diagnostics) an...

journal_title：Contrast media & molecular imaging

authors： Hyder F,Manjura Hoque S

更新日期：2017-12-11 00:00:00

abstract：:Advances in regenerative medicine are rapidly transforming healthcare. A cornerstone of regenerative medicine is the introduction of cells that were grown or manipulated in vitro. Key questions that arise after these cells are re-introduced are: whether these cells are localized in the appropriate site; whether cells ...

journal_title：Contrast media & molecular imaging

authors： Modo M,Kolosnjaj-Tabi J,Nicholls F,Ling W,Wilhelm C,Debarge O,Gazeau F,Clement O

更新日期：2013-11-01 00:00:00

abstract：:Monodisperse mesoporous silica (mSiO(2) ) coated superparamagnetic iron oxide (Fe(3) O(4) @mSiO(2) ) nanoparticles (NPs) have been developed as a potential magnetic resonance imaging (MRI) T(2) contrast agent. To evaluate the effect of surface coating on MRI contrast efficiency, we examined the proton relaxivities of ...

journal_title：Contrast media & molecular imaging

authors： Ye F,Laurent S,Fornara A,Astolfi L,Qin J,Roch A,Martini A,Toprak MS,Muller RN,Muhammed M

更新日期：2012-09-01 00:00:00

abstract：Objective:To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods:The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently perform...

journal_title：Contrast media & molecular imaging

authors： Otnes S,Fogh-Andersen N,Rømsing J,Thomsen HS

更新日期：2017-04-10 00:00:00

abstract：Background:To evaluate the clinical and prognostic value of PET/CT with combination of 68Ga-DOTATATE and 18F-FDG in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Method:83 patients of GEP-NENs who underwent 68Ga-DOTATATE and 18F-FDG PET/CT were enrolled between June 2013 and December 2016. Well-different...

journal_title：Contrast media & molecular imaging

authors： Zhang P,Yu J,Li J,Shen L,Li N,Zhu H,Zhai S,Zhang Y,Yang Z,Lu M

更新日期：2018-02-26 00:00:00

abstract：:A novel tumor stroma targeting and membrane-penetrating cyclic peptide, named iCREKA, was designed and labeled by fluorescein isothiocyanate (FITC) and positron emitter 18F to build the tumor-targeting tracers. The FITC-iCREKA was proved to have significantly higher cellular uptake in the glioma U87 cells in the prese...

journal_title：Contrast media & molecular imaging

authors： Wang LJ,Li HS,Wang QS,Wu HB,Han YJ,Zhou WL,Wang M,Huang S

更新日期：2018-03-04 00:00:00

abstract：:Physicians and scientists use a broad spectrum of terms to classify contrast media (CM)-induced adverse reactions. In particular, the designation of hypersensitivity reactions is quite varied. Consequently, comparisons of different papers dealing with this subject are difficult or even impossible. Moreover, general de...

journal_title：Contrast media & molecular imaging

authors： Böhm I,Heverhagen JT,Klose KJ

更新日期：2012-11-01 00:00:00

abstract：:Generally angiogenic factors induce the expression of E-selectin in vascular endothelial cells in the tumors. In this study, we employed an anti-E-selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visualize tumor regions. The anti-E-selectin antibody was conjugated on th...

journal_title：Contrast media & molecular imaging

authors： Hirai M,Hiramatsu Y,Iwashita S,Otani T,Chen L,Li YG,Okada M,Oie K,Igarashi K,Wakita H,Seno M

更新日期：2010-03-01 00:00:00

abstract：:Recent advances in artificial intelligence (AI) and deep learning (DL) have impacted many scientific fields including biomedical maging. Magnetic resonance imaging (MRI) is a well-established method in breast imaging with several indications including screening, staging, and therapy monitoring. The rapid development a...

journal_title：Contrast media & molecular imaging

authors： Meyer-Bäse A,Morra L,Meyer-Bäse U,Pinker K

更新日期：2020-08-28 00:00:00

abstract：:Red blood cells (RBCs) loaded with iron oxide nanoparticles have been proposed as biomimetic constructs with long half-life (ca. 20 days) in the blood compartment and potentially interesting properties (such as relaxivity) as intravascular contrast agents for magnetic resonance imaging. However, the encapsulation of n...

journal_title：Contrast media & molecular imaging

authors： Boni A,Ceratti D,Antonelli A,Sfara C,Magnani M,Manuali E,Salamida S,Gozzi A,Bifone A

更新日期：2014-05-01 00:00:00

abstract：:The aim of the present study was to test alginate gels of different compositions as a system for controlled release of manganese ions (Mn(2+)) for application in manganese-enhanced MRI (MEMRI), in order to circumvent the challenge of achieving optimal MRI resolution without resorting to high, potentially cytotoxic dos...

journal_title：Contrast media & molecular imaging

authors： Mørch YA,Sandvig I,Olsen O,Donati I,Thuen M,Skjåk-Braek G,Haraldseth O,Brekken C

更新日期：2012-03-01 00:00:00

abstract：:An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Altho...

journal_title：Contrast media & molecular imaging

authors： van Schooneveld MM,Cormode DP,Koole R,van Wijngaarden JT,Calcagno C,Skajaa T,Hilhorst J,'t Hart DC,Fayad ZA,Mulder WJ,Meijerink A

更新日期：2010-07-01 00:00:00

abstract：:Melanoma is the most dangerous form of skin cancer and its incidence is rising each year. Because the current methods of diagnosis based on the visual aspect of the tumor show limitations, several new techniques are emerging to help in this diagnosis, amongst which are magnetic resonance imaging (MRI) and electron par...

journal_title：Contrast media & molecular imaging

authors： Godechal Q,Mignion L,Karroum O,Magat J,Danhier P,Morandini R,Ghanem GE,Leveque P,Gallez B

更新日期：2014-03-01 00:00:00

abstract：Aim:To evaluate reproducibility and stability of radiomic features as effects of the use of different volume segmentation methods and reconstruction settings. The potential of radiomics in really capturing the presence of heterogeneous tumor uptake and irregular shape was also investigated. Materials and Methods:An an...

journal_title：Contrast media & molecular imaging

authors： Gallivanone F,Interlenghi M,D'Ambrosio D,Trifirò G,Castiglioni I

更新日期：2018-09-10 00:00:00

abstract：:The use of superparamagnetic iron oxide (SPIO) for labeling cells holds great promise for clinically applicable cell tracking using magnetic resonance imaging. For clinical application, an effectively and specifically labeled cell preparation is highly desired (i.e. a large amount of intracellular iron and a negligibl...

journal_title：Contrast media & molecular imaging

authors： van Buul GM,Farrell E,Kops N,van Tiel ST,Bos PK,Weinans H,Krestin GP,van Osch GJ,Bernsen MR

更新日期：2009-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/7368384.]. ...

journal_title：Contrast media & molecular imaging

authors： Tse JJ,Dunmore-Buyze PJ,Drangova M,Holdsworth DW

更新日期：2018-08-23 00:00:00

abstract：:Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new metho...

journal_title：Contrast media & molecular imaging

authors： Tran VL,Thakare V,Natuzzi M,Moreau M,Oudot A,Vrigneaud JM,Courteau A,Louis C,Roux S,Boschetti F,Denat F,Tillement O,Lux F

更新日期：2018-11-01 00:00:00

abstract：:In vivo molecular imaging with targeted MRI contrast agents will require sensitive methods to quantify local concentrations of contrast agent, enabling not only imaging-based recognition of pathological biomarkers but also detection of changes in expression levels as a consequence of disease development, therapeutic i...

journal_title：Contrast media & molecular imaging

authors： Kok MB,de Vries A,Abdurrachim D,Prompers JJ,Grüll H,Nicolay K,Strijkers GJ

更新日期：2011-01-01 00:00:00

abstract：:Chemical exchange saturation transfer (CEST) imaging is an emerging MRI technique relying on the use of endogenous or exogenous molecules containing exchangeable proton pools. The heterogeneity of the water resonance frequency offset plays a key role in the occurrence of artifacts in CEST-MR images. To limit this draw...

journal_title：Contrast media & molecular imaging

authors： Stancanello J,Terreno E,Castelli DD,Cabella C,Uggeri F,Aime S

更新日期：2008-07-01 00:00:00

abstract：:A generic site-specific conjugation method that generates a homogeneous product is of utmost importance in tracer development for molecular imaging and therapy. We explored the protein-ligation capacity of the enzyme Sortase A to label camelid single-domain antibody-fragments, also known as nanobodies. The versatility...

journal_title：Contrast media & molecular imaging

authors： Massa S,Vikani N,Betti C,Ballet S,Vanderhaegen S,Steyaert J,Descamps B,Vanhove C,Bunschoten A,van Leeuwen FW,Hernot S,Caveliers V,Lahoutte T,Muyldermans S,Xavier C,Devoogdt N

更新日期：2016-09-01 00:00:00