Increased myocardial wall thickening as index of viability assessment: a preliminary report on delayed contrast MRI.


PURPOSE:Regional wall thickening measurement by delayed contrast MRI may assess myocardial viability and functional recovery of ischemic cardiomyopathy. MATERIALS AND METHODS:Delayed contrast MRI data was used in 40 patients with significant coronary artery disease and severe left ventricular dysfunction. Regional wall thickening on follow-up MRI served as an index of functional recovery in patients receiving revascularization. For comparison, myocardial viability was assessed by MRI and 201Tl SPECT in 10 patients using a 17-segment method. RESULTS:On 480 segments, MRI hyperintensities showed positive correlation with 201Tl reduction (r = 0.71, p < 0.0001) in the inferior wall and apex. Delayed MRI detected myocardial viability better than 201Tl SPECT. Delayed contrast-enhanced MRI showed diagnostic accuracy 65%, sensitivity 95%, specificity 25%, positive predictive value 65% and negative predictive value 75%, whereas 201Tl SPECT showed diagnostic accuracy 54%, sensitivity 72%, specificity 25%, positive predictive value 52% and negative predictive value 54%. Areas under the ROC curves by MRI and 201Tl SPECT were 0.59 +/- 0.04, 0.52 +/- 0.05, respectively (p = 0.07). The viability concordance was 80% between 201Tl SPECT and MRI. CONCLUSION:Delayed contrast-enhanced MRI may detect the inferior wall thickening and apex as an index of viable myocardium better than 201Tl SPECT. Myocardial viability may predict functional recovery after revascularization in ischemic cardiomyopathy.


Sharma R,Katz JK




Has Abstract


2009-01-01 00:00:00












  • Mn-alginate gels as a novel system for controlled release of Mn2+ in manganese-enhanced MRI.

    abstract::The aim of the present study was to test alginate gels of different compositions as a system for controlled release of manganese ions (Mn(2+)) for application in manganese-enhanced MRI (MEMRI), in order to circumvent the challenge of achieving optimal MRI resolution without resorting to high, potentially cytotoxic dos...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Mørch YA,Sandvig I,Olsen O,Donati I,Thuen M,Skjåk-Braek G,Haraldseth O,Brekken C

    更新日期:2012-03-01 00:00:00

  • Hepatic 18F-FDG Uptake Measurements on PET/MR: Impact of Volume of Interest Location on Repeatability.

    abstract:Background:To investigate same day 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography)/MR (Magnetic Resonance) test-retest repeatability of Standardized Uptake Value measurements normalized for body weight (SUV) and lean body mass (SUL) in different locations in the liver. Methods:This prospective study wa...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Domachevsky L,Bernstine H,Nidam M,Stein D,Goldberg N,Stern D,Abadi-Korek I,Groshar D

    更新日期:2017-05-30 00:00:00

  • Influence of paramagnetic melanin on the MRI contrast in melanoma: a combined high-field (11.7 T) MRI and EPR study.

    abstract::Melanoma is the most dangerous form of skin cancer and its incidence is rising each year. Because the current methods of diagnosis based on the visual aspect of the tumor show limitations, several new techniques are emerging to help in this diagnosis, amongst which are magnetic resonance imaging (MRI) and electron par...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Godechal Q,Mignion L,Karroum O,Magat J,Danhier P,Morandini R,Ghanem GE,Leveque P,Gallez B

    更新日期:2014-03-01 00:00:00

  • Clinical applications of spectral molecular imaging: potential and challenges.

    abstract::Spectral molecular imaging is a new X-ray-based imaging technology providing highly specific 3D imaging at high spatial resolution that has the potential to measure disease activity and response to treatment noninvasively. The ability to identify and quantify components of tissue and biomarkers of disease activity der...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章,评审


    authors: Anderson NG,Butler AP

    更新日期:2014-01-01 00:00:00

  • Considerations for the clinical use of contrast agents for cellular MRI in regenerative medicine.

    abstract::Advances in regenerative medicine are rapidly transforming healthcare. A cornerstone of regenerative medicine is the introduction of cells that were grown or manipulated in vitro. Key questions that arise after these cells are re-introduced are: whether these cells are localized in the appropriate site; whether cells ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章,评审


    authors: Modo M,Kolosnjaj-Tabi J,Nicholls F,Ling W,Wilhelm C,Debarge O,Gazeau F,Clement O

    更新日期:2013-11-01 00:00:00

  • USPIO-loaded red blood cells as a biomimetic MR contrast agent: a relaxometric study.

    abstract::Red blood cells (RBCs) loaded with iron oxide nanoparticles have been proposed as biomimetic constructs with long half-life (ca. 20 days) in the blood compartment and potentially interesting properties (such as relaxivity) as intravascular contrast agents for magnetic resonance imaging. However, the encapsulation of n...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Boni A,Ceratti D,Antonelli A,Sfara C,Magnani M,Manuali E,Salamida S,Gozzi A,Bifone A

    更新日期:2014-05-01 00:00:00

  • Corrigendum to "Erbium-Based Perfusion Contrast Agent for Small-Animal Microvessel Imaging".

    abstract::[This corrects the article DOI: 10.1155/2017/7368384.]. ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章,已发布勘误


    authors: Tse JJ,Dunmore-Buyze PJ,Drangova M,Holdsworth DW

    更新日期:2018-08-23 00:00:00

  • VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice.

    abstract::The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research applications. In that context, a photoacoustic molecular probe based on ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Rouleau L,Berti R,Ng VW,Matteau-Pelletier C,Lam T,Saboural P,Kakkar AK,Lesage F,Rhéaume E,Tardif JC

    更新日期:2013-01-01 00:00:00

  • Improved detection of pancreatic islets in vivo using double contrast.

    abstract::The transplantation of pancreatic islets containing β-cells, which produce insulin, is an alternative approach to the treatment of type 1 diabetes mellitus. The non-invasive visualization of transplanted islets can be performed using MRI; however, this requires labeling of the islets with a suitable contrast agent pri...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Herynek V,Berková Z,Dovolilová E,Jirák D,Kříž J,Girman P,Saudek F,Hájek M

    更新日期:2011-07-01 00:00:00

  • A First Report on [18F]FPRGD2 PET/CT Imaging in Multiple Myeloma.

    abstract::An observational study was set up to assess the feasibility of [18F]FPRGD2 PET/CT for imaging patients with multiple myeloma (MM) and to compare its detection rate with low dose CT alone and combined [18F]NaF/[18F]FDG PET/CT images. Four patients (2 newly diagnosed patients and 2 with relapsed MM) were included and un...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Withofs N,Cousin F,De Prijck B,Bonnet C,Hustinx R,Gambhir SS,Beguin Y,Caers J

    更新日期:2017-07-27 00:00:00

  • Gadobutrol Precedes Gd-DTPA in Abdominal Contrast-Enhanced MRA and MRI: A Prospective, Multicenter, Intraindividual Study.

    abstract:Objective:To qualitatively and quantitatively compare the contrast-enhanced magnetic resonance angiography (MRA) and magnetic resonance imaging (MRI) in one-stop shop of abdominal imaging with Gadobutrol and Gd-DTPA at equimolar doses of gadolinium. Materials and Methods:This was a prospective designed, multiple cente...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Liu X,Li Z,Zhang W,Yang C,Diao Y,Duan T,Fu Y,Ren J,Bin S

    更新日期:2019-12-02 00:00:00

  • How to perform accurate and reliable measurements of longitudinal and transverse relaxation times of MRI contrast media in aqueous solutions.

    abstract::Knowledge of the longitudinal and transverse relaxation times (T(1) and T(2)) of water protons in an aqueous solution of an MRI contrast agent is essential for its characterization. These parameters can be measured at low field on low resolution spectrometers or at high field on high resolution spectrometers. The reli...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Henoumont C,Laurent S,Vander Elst L

    更新日期:2009-11-01 00:00:00

  • Quantitative chemical exchange saturation transfer (qCEST) MRI--RF spillover effect-corrected omega plot for simultaneous determination of labile proton fraction ratio and exchange rate.

    abstract::Chemical exchange saturation transfer (CEST) MRI is sensitive to dilute proteins and peptides as well as microenvironmental properties. However, the complexity of the CEST MRI effect, which varies with the labile proton content, exchange rate and experimental conditions, underscores the need for developing quantitativ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Sun PZ,Wang Y,Dai Z,Xiao G,Wu R

    更新日期:2014-07-01 00:00:00

  • Phenylboronate 160Tb complexes for molecular recognition of glycoproteins expressed on tumor cells.

    abstract::The over-expression of sialic acid on the surface of cancer cells compared with normal ones makes this nine-carbon sugar an attractive biomarker for molecular diagnosis and therapy. Here, we describe a study on the molecular recognition of sialic acid end groups on the surface of human glioma cells by (160)Tb-DTPA-EN(...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Djanashvili K,Koning GA,van der Meer AJ,Wolterbeek HT,Peters JA

    更新日期:2007-01-01 00:00:00

  • Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry.

    abstract::Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared 68Ga-DOTA- and 18F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-S...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Virtanen H,Silvola JMU,Autio A,Li XG,Liljenbäck H,Hellberg S,Siitonen R,Ståhle M,Käkelä M,Airaksinen AJ,Helariutta K,Tolvanen T,Veres TZ,Saraste A,Knuuti J,Jalkanen S,Roivainen A

    更新日期:2017-12-31 00:00:00

  • Contrast-Enhanced Microtomographic Characterisation of Vessels in Native Bone and Engineered Vascularised Grafts Using Ink-Gelatin Perfusion and Phosphotungstic Acid.

    abstract:Objectives:Bone ischemia and necrosis are challenging to treat, requiring investigation of native and engineered bone revascularisation processes through advanced imaging techniques. This study demonstrates an experimental two-step method for precise bone and vessel analysis in native bones or vascularised bone grafts ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Sutter S,Todorov A,Ismail T,Haumer A,Fulco I,Schulz G,Scherberich A,Kaempfen A,Martin I,Schaefer DJ

    更新日期:2017-04-23 00:00:00

  • Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging.

    abstract:Objective:The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (13C) metabolic imaging with [1-13C]-labeled pyruvate for evaluating real-time in vivo metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. Materials and Methods:3D 13C magnetic resonance sp...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Autry AW,Hashizume R,James CD,Larson PEZ,Vigneron DB,Park I

    更新日期:2018-07-30 00:00:00

  • Spectroscopic, radiochemical, and theoretical studies of the Ga3+-N-2-hydroxyethyl piperazine-N'-2-ethanesulfonic acid (HEPES buffer) system: evidence for the formation of Ga3+ - HEPES complexes in (68) Ga labeling reactions.

    abstract::Recent reports have claimed a superior performance of HEPES buffer in comparison to alternative buffer systems for (67/68) Ga labeling in aqueous media. In this paper we report spectroscopic ((1) H and (71) Ga NMR), radiochemical, mass spectrometry and theoretical modeling studies on the Ga(3+)/HEPES system (HEPES = N...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Martins AF,Prata MI,Rodrigues SP,Geraldes CF,Riss PJ,Amor-Coarasa A,Burchardt C,Kroll C,Roesch F

    更新日期:2013-05-01 00:00:00

  • Contrast-Enhanced MicroCT for Virtual 3D Anatomical Pathology of Biological Tissues: A Literature Review.

    abstract::To date, the combination of histological sectioning, staining, and microscopic assessment of the 2D sections is still the golden standard for structural and compositional analysis of biological tissues. X-ray microfocus computed tomography (microCT) is an emerging 3D imaging technique with high potential for 3D struct...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章,评审


    authors: de Bournonville S,Vangrunderbeeck S,Kerckhofs G

    更新日期:2019-02-28 00:00:00

  • Characterization of MRI contrast agent-loaded polymeric nanocapsules as versatile vehicle for targeted imaging.

    abstract::Various contrast agents (Magnevist, Gadovist and Multihance) loaded into polymeric nanocapsules were synthesized by the inverse miniemulsion technique. The relaxivity of the resultant contrast agents was assessed at 1.5 T magnetic field strength. The ionic relaxivity of the contrast agents could at least be maintained...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Sharma S,Paiphansiri U,Hombach V,Mailänder V,Zimmermann O,Landfester K,Rasche V

    更新日期:2010-03-01 00:00:00

  • F-18 FP-CIT PET in Multiple System Atrophy of the Cerebellar Type: Additional Role in Treatment.

    abstract::We evaluated the difference in the status of dopamine transporters (DATs) depending on Parkinsonism, cerebellar, and autonomic features using F-18 FP-CIT positron emission tomography (PET) in multiple system atrophy with cerebellar ataxia (MSA-C). We also assessed whether the DAT PET could be useful in the management ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Jeong YJ,Cheon SM,Kang DY,Kim JW

    更新日期:2017-11-29 00:00:00

  • Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases.

    abstract::Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. These probes were based on the PLG*LWAR peptide sequence, known to be hydrolyzed between Gly and Leu by a broad panel of MMPs. A Gd-DOTA chelate was conjugated...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Gringeri CV,Menchise V,Rizzitelli S,Cittadino E,Catanzaro V,Dati G,Chaabane L,Digilio G,Aime S

    更新日期:2012-03-01 00:00:00

  • Electron paramagnetic resonance as a sensitive tool to assess the iron oxide content in cells for MRI cell labeling studies.

    abstract::MRI cell tracking is a promising technique to track various cell types (stem cells, tumor cells, etc.) in living animals. Usually, cells are incubated with iron oxides (T(2) contrast agent) in order to take up the particles before being injected in vivo. Iron oxide quantification is important in such studies for valid...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Danhier P,De Preter G,Boutry S,Mahieu I,Leveque P,Magat J,Haufroid V,Sonveaux P,Bouzin C,Feron O,Muller RN,Jordan BF,Gallez B

    更新日期:2012-05-01 00:00:00

  • Use of 18F-FDG-PET/CT for Retroperitoneal/Intra-Abdominal Soft Tissue Sarcomas.

    abstract:Rationale:To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods:195 patients with 44 different diseases have been included. Relatio...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Liu DN,Li ZW,Wang HY,Zhao M,Zhao W,Hao CY

    更新日期:2018-07-02 00:00:00

  • Quantitative (1)H MRI, (19)F MRI, and (19)F MRS of cell-internalized perfluorocarbon paramagnetic nanoparticles.

    abstract::In vivo molecular imaging with targeted MRI contrast agents will require sensitive methods to quantify local concentrations of contrast agent, enabling not only imaging-based recognition of pathological biomarkers but also detection of changes in expression levels as a consequence of disease development, therapeutic i...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Kok MB,de Vries A,Abdurrachim D,Prompers JJ,Grüll H,Nicolay K,Strijkers GJ

    更新日期:2011-01-01 00:00:00

  • Ability of 18F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma.

    abstract::Purpose. To investigate the value of SUV metrics and radiomic features based on the ability of 18F-FDG PET/CT in differentiating between breast lymphoma and breast carcinoma. Methods. A total of 67 breast nodules from 44 patients who underwent 18F-FDG PET/CT pretreatment were retrospectively analyzed. Radiomic paramet...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Ou X,Wang J,Zhou R,Zhu S,Pang F,Zhou Y,Tian R,Ma X

    更新日期:2019-02-25 00:00:00

  • Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe.

    abstract::In this study we report the development of a bioconjugate between superparamagnetic iron oxide nanoparticles and Phl p5a (one of the major allergens from grass pollen). The bioconjugate also contains an optical probe (Alexa647) conjugated to the nanoparticle via biotin-streptavidin association. We show that this conju...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Herranz F,Schmidt-Weber CB,Shamji MH,Narkus A,Ruiz-Cabello J,Vilar R

    更新日期:2012-07-01 00:00:00

  • Multimodal approach to assess tumour vasculature and potential treatment effect with DCE-US and DCE-MRI quantification in CWR22 prostate tumour xenografts.

    abstract::The aim of this study was to compare intratumoural heterogeneity and longitudinal changes assessed by dynamic contrast-enhanced ultrasound (DCE-US) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in prostate tumour xenografts. In vivo DCE-US and DCE-MRI were obtained 24 h pre- (day 0) and post- (day...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Arteaga-Marrero N,Rygh CB,Mainou-Gomez JF,Nylund K,Roehrich D,Heggdal J,Matulaniec P,Gilja OH,Reed RK,Svensson L,Lutay N,Olsen DR

    更新日期:2015-11-01 00:00:00

  • Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images.

    abstract::Chemical exchange saturation transfer (CEST) imaging is an emerging MRI technique relying on the use of endogenous or exogenous molecules containing exchangeable proton pools. The heterogeneity of the water resonance frequency offset plays a key role in the occurrence of artifacts in CEST-MR images. To limit this draw...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Stancanello J,Terreno E,Castelli DD,Cabella C,Uggeri F,Aime S

    更新日期:2008-07-01 00:00:00

  • High-throughput screening of chemical exchange saturation transfer MR contrast agents.

    abstract::A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章


    authors: Liu G,Gilad AA,Bulte JW,van Zijl PC,McMahon MT

    更新日期:2010-05-01 00:00:00