How to perform accurate and reliable measurements of longitudinal and transverse relaxation times of MRI contrast media in aqueous solutions.

abstract：:Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of 99mTc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-99mTc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR...

journal_title：Contrast media & molecular imaging

authors： Vallejo-Armenta P,Santos-Cuevas C,Soto-Andonaegui J,Villanueva-Pérez RM,González-Díaz JI,García-Pérez FO,Arrellano-Zarate A,Luna-Gutiérrez M,Azorín-Vega E,Ocampo-García B,Ferro-Flores G

更新日期：2020-04-27 00:00:00

abstract：:The over-expression of sialic acid on the surface of cancer cells compared with normal ones makes this nine-carbon sugar an attractive biomarker for molecular diagnosis and therapy. Here, we describe a study on the molecular recognition of sialic acid end groups on the surface of human glioma cells by (160)Tb-DTPA-EN(...

journal_title：Contrast media & molecular imaging

authors： Djanashvili K,Koning GA,van der Meer AJ,Wolterbeek HT,Peters JA

更新日期：2007-01-01 00:00:00

abstract：Rationale:To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods:195 patients with 44 different diseases have been included. Relatio...

journal_title：Contrast media & molecular imaging

authors： Liu DN,Li ZW,Wang HY,Zhao M,Zhao W,Hao CY

更新日期：2018-07-02 00:00:00

abstract：:Chemical exchange saturation transfer (CEST) imaging is an emerging MRI technique relying on the use of endogenous or exogenous molecules containing exchangeable proton pools. The heterogeneity of the water resonance frequency offset plays a key role in the occurrence of artifacts in CEST-MR images. To limit this draw...

journal_title：Contrast media & molecular imaging

authors： Stancanello J,Terreno E,Castelli DD,Cabella C,Uggeri F,Aime S

更新日期：2008-07-01 00:00:00

abstract：:For in vivo applications of magnetically labeled stem cells, biological effects of the labeling procedure have to be precluded. This study evaluates the effect of different ferucarbotran cell labeling protocols on chondrogenic differentiation of human mesenchymal stem cells (hMSC) as well as their implications for MR ...

journal_title：Contrast media & molecular imaging

authors： Henning TD,Sutton EJ,Kim A,Golovko D,Horvai A,Ackerman L,Sennino B,McDonald D,Lotz J,Daldrup-Link HE

更新日期：2009-07-01 00:00:00

abstract：:Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new metho...

journal_title：Contrast media & molecular imaging

authors： Tran VL,Thakare V,Natuzzi M,Moreau M,Oudot A,Vrigneaud JM,Courteau A,Louis C,Roux S,Boschetti F,Denat F,Tillement O,Lux F

更新日期：2018-11-01 00:00:00

abstract：:MRI cell tracking is a promising technique to track various cell types (stem cells, tumor cells, etc.) in living animals. Usually, cells are incubated with iron oxides (T(2) contrast agent) in order to take up the particles before being injected in vivo. Iron oxide quantification is important in such studies for valid...

journal_title：Contrast media & molecular imaging

authors： Danhier P,De Preter G,Boutry S,Mahieu I,Leveque P,Magat J,Haufroid V,Sonveaux P,Bouzin C,Feron O,Muller RN,Jordan BF,Gallez B

更新日期：2012-05-01 00:00:00

abstract：:An observational study was set up to assess the feasibility of [18F]FPRGD2 PET/CT for imaging patients with multiple myeloma (MM) and to compare its detection rate with low dose CT alone and combined [18F]NaF/[18F]FDG PET/CT images. Four patients (2 newly diagnosed patients and 2 with relapsed MM) were included and un...

journal_title：Contrast media & molecular imaging

authors： Withofs N,Cousin F,De Prijck B,Bonnet C,Hustinx R,Gambhir SS,Beguin Y,Caers J

更新日期：2017-07-27 00:00:00

abstract：:Quantum dots (QDs) are fluorescent nanoparticles with broad excitation and narrow, wavelength-tunable emission spectra. They are used extensively for in vitro fluorescence imaging studies and more recently for in vivo small animal and pre-clinical studies. To date there has been little concern about the selection of Q...

journal_title：Contrast media & molecular imaging

authors： Rosenblum LT,Kosaka N,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2011-05-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:The purpose of this pilot study was to establish the ability of dynamic contrast enhanced computed tomography (DCE-CT) to detect changes in tumor blood flow (BF) and oxygenation induced by vasoactive substances in rats. MATERIALS AND METHODS:Under ultrasound guidance, a fiber-optic probe was g...

journal_title：Contrast media & molecular imaging

authors： Pollard RE,Larson RF

更新日期：2011-01-01 00:00:00

abstract：Background:To investigate same day 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography)/MR (Magnetic Resonance) test-retest repeatability of Standardized Uptake Value measurements normalized for body weight (SUV) and lean body mass (SUL) in different locations in the liver. Methods:This prospective study wa...

journal_title：Contrast media & molecular imaging

authors： Domachevsky L,Bernstine H,Nidam M,Stein D,Goldberg N,Stern D,Abadi-Korek I,Groshar D

更新日期：2017-05-30 00:00:00

abstract：:Gold nanoparticles coated by gadolinium (III) chelates (Au@DTDTPA) where DTDTPA is a dithiolated bisamide derivative of diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), constituted contrast agents for both X-ray computed tomography and magnetic resonance imaging. In an MRI context, highly stable Gd(3+) compl...

journal_title：Contrast media & molecular imaging

authors： Mogilireddy V,Déchamps-Olivier I,Alric C,Laurent G,Laurent S,Vander Elst L,Muller R,Bazzi R,Roux S,Tillement O,Chuburu F

更新日期：2015-05-01 00:00:00

abstract：:Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...

journal_title：Contrast media & molecular imaging

authors： Xu RX

更新日期：2011-09-01 00:00:00

abstract：:The aim of the present study was to test alginate gels of different compositions as a system for controlled release of manganese ions (Mn(2+)) for application in manganese-enhanced MRI (MEMRI), in order to circumvent the challenge of achieving optimal MRI resolution without resorting to high, potentially cytotoxic dos...

journal_title：Contrast media & molecular imaging

authors： Mørch YA,Sandvig I,Olsen O,Donati I,Thuen M,Skjåk-Braek G,Haraldseth O,Brekken C

更新日期：2012-03-01 00:00:00

abstract：:A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...

journal_title：Contrast media & molecular imaging

authors： Liu G,Gilad AA,Bulte JW,van Zijl PC,McMahon MT

更新日期：2010-05-01 00:00:00

abstract：:In this study we report the development of a bioconjugate between superparamagnetic iron oxide nanoparticles and Phl p5a (one of the major allergens from grass pollen). The bioconjugate also contains an optical probe (Alexa647) conjugated to the nanoparticle via biotin-streptavidin association. We show that this conju...

journal_title：Contrast media & molecular imaging

authors： Herranz F,Schmidt-Weber CB,Shamji MH,Narkus A,Ruiz-Cabello J,Vilar R

更新日期：2012-07-01 00:00:00

abstract：Objectives:Bone ischemia and necrosis are challenging to treat, requiring investigation of native and engineered bone revascularisation processes through advanced imaging techniques. This study demonstrates an experimental two-step method for precise bone and vessel analysis in native bones or vascularised bone grafts ...

journal_title：Contrast media & molecular imaging

authors： Sutter S,Todorov A,Ismail T,Haumer A,Fulco I,Schulz G,Scherberich A,Kaempfen A,Martin I,Schaefer DJ

更新日期：2017-04-23 00:00:00

abstract：:The use of superparamagnetic iron oxide (SPIO) for labeling cells holds great promise for clinically applicable cell tracking using magnetic resonance imaging. For clinical application, an effectively and specifically labeled cell preparation is highly desired (i.e. a large amount of intracellular iron and a negligibl...

journal_title：Contrast media & molecular imaging

authors： van Buul GM,Farrell E,Kops N,van Tiel ST,Bos PK,Weinans H,Krestin GP,van Osch GJ,Bernsen MR

更新日期：2009-09-01 00:00:00

abstract：:Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. These probes were based on the PLG*LWAR peptide sequence, known to be hydrolyzed between Gly and Leu by a broad panel of MMPs. A Gd-DOTA chelate was conjugated...

journal_title：Contrast media & molecular imaging

authors： Gringeri CV,Menchise V,Rizzitelli S,Cittadino E,Catanzaro V,Dati G,Chaabane L,Digilio G,Aime S

更新日期：2012-03-01 00:00:00

abstract：:Stem cells, cancer cells and immune cells were labeled by co-incubation with a new ultra-small iron oxide nanoparticle called Molday ION Rhodamine-B (MIRB). Iron staining, fluorescence imaging, transmission electron microscopy and flow cytometry were used to assess cell viability, function and labeling efficiency. Thi...

journal_title：Contrast media & molecular imaging

authors： McFadden C,Mallett CL,Foster PJ

更新日期：2011-11-01 00:00:00

abstract：Aim:To evaluate reproducibility and stability of radiomic features as effects of the use of different volume segmentation methods and reconstruction settings. The potential of radiomics in really capturing the presence of heterogeneous tumor uptake and irregular shape was also investigated. Materials and Methods:An an...

journal_title：Contrast media & molecular imaging

authors： Gallivanone F,Interlenghi M,D'Ambrosio D,Trifirò G,Castiglioni I

更新日期：2018-09-10 00:00:00

abstract：:Purpose. To investigate the value of SUV metrics and radiomic features based on the ability of 18F-FDG PET/CT in differentiating between breast lymphoma and breast carcinoma. Methods. A total of 67 breast nodules from 44 patients who underwent 18F-FDG PET/CT pretreatment were retrospectively analyzed. Radiomic paramet...

journal_title：Contrast media & molecular imaging

authors： Ou X,Wang J,Zhou R,Zhu S,Pang F,Zhou Y,Tian R,Ma X

更新日期：2019-02-25 00:00:00

abstract：:We evaluated the difference in the status of dopamine transporters (DATs) depending on Parkinsonism, cerebellar, and autonomic features using F-18 FP-CIT positron emission tomography (PET) in multiple system atrophy with cerebellar ataxia (MSA-C). We also assessed whether the DAT PET could be useful in the management ...

journal_title：Contrast media & molecular imaging

authors： Jeong YJ,Cheon SM,Kang DY,Kim JW

更新日期：2017-11-29 00:00:00

abstract：:In the pursuit of understanding the pathological alterations that underlie ischaemic injuries, such as vascular remodelling and reorganisation, there is a need for recognising the capabilities and limitations of in vivo imaging techniques. Thus, this review presents contemporary published research of imaging modalitie...

journal_title：Contrast media & molecular imaging

authors： Gandhi R,Tsoumpas C

更新日期：2019-02-03 00:00:00

abstract：:Self-aggregation of dyes even at low concentrations poses a considerable challenge in preparing sufficiently bright molecular probes for in vivo imaging, particularly in the conjugation of near infrared cyanine dyes to polypeptides with multiple labeling sites. Such self-aggregation leads to a significant energy trans...

journal_title：Contrast media & molecular imaging

authors： Zhegalova NG,He S,Zhou H,Kim DM,Berezin MY

更新日期：2014-09-01 00:00:00

abstract：:Antibody-labeled gold nanoparticles represent a promising novel tool regarding cancer imaging and therapy. Nevertheless, the characterization of biodistribution of such immunonanocarriers has been poorly documented. In this study, the biodistribution of (89)Zr-labeled cetuximab before and after the coupling reaction t...

journal_title：Contrast media & molecular imaging

authors： Karmani L,Labar D,Valembois V,Bouchat V,Nagaswaran PG,Bol A,Gillart J,Levêque P,Bouzin C,Bonifazi D,Michiels C,Feron O,Grégoire V,Lucas S,Vander Borght T,Gallez B

更新日期：2013-09-01 00:00:00

abstract：:The combination of the size-dependent properties of nanomaterials with radioisotopes is emerging as a novel tool for molecular imaging. There are numerous examples already showing how the controlled synthesis of nanoparticles and the incorporation of a radioisotope in the nanostructure offer new features beyond the si...

journal_title：Contrast media & molecular imaging

authors： Pellico J,Llop J,Fernández-Barahona I,Bhavesh R,Ruiz-Cabello J,Herranz F

更新日期：2017-11-21 00:00:00

abstract：:D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome P glycoprotein efflux as well...

journal_title：Contrast media & molecular imaging

authors： Tesan FC,Nicoud MB,Nuñez M,Medina VA,Chiappetta DA,Salgueiro MJ

更新日期：2019-04-23 00:00:00

abstract：:Generally angiogenic factors induce the expression of E-selectin in vascular endothelial cells in the tumors. In this study, we employed an anti-E-selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visualize tumor regions. The anti-E-selectin antibody was conjugated on th...

journal_title：Contrast media & molecular imaging

authors： Hirai M,Hiramatsu Y,Iwashita S,Otani T,Chen L,Li YG,Okada M,Oie K,Igarashi K,Wakita H,Seno M

更新日期：2010-03-01 00:00:00

abstract：:Recent advances in artificial intelligence (AI) and deep learning (DL) have impacted many scientific fields including biomedical maging. Magnetic resonance imaging (MRI) is a well-established method in breast imaging with several indications including screening, staging, and therapy monitoring. The rapid development a...

journal_title：Contrast media & molecular imaging

authors： Meyer-Bäse A,Morra L,Meyer-Bäse U,Pinker K

更新日期：2020-08-28 00:00:00