Abstract:
:An observational study was set up to assess the feasibility of [18F]FPRGD2 PET/CT for imaging patients with multiple myeloma (MM) and to compare its detection rate with low dose CT alone and combined [18F]NaF/[18F]FDG PET/CT images. Four patients (2 newly diagnosed patients and 2 with relapsed MM) were included and underwent whole-body PET/CT after injection of [18F]FPRGD2. The obtained images were compared with results of low dose CT and already available results of a combined [18F]NaF/[18F]FDG PET/CT. In total, 81 focal lesions (FLs) were detected with PET/CT and an underlying bone destruction or fracture was seen in 72 (89%) or 8 (10%) FLs, respectively. Fewer FLs (54%) were detected by [18F]FPRGD2 PET/CT compared to low dose CT (98%) or [18F]NaF/[18F]FDG PET/CT (70%) and all FLs detected with [18F]FPRGD2 PET were associated with an underlying bone lesion. In one newly diagnosed patient, more [18F]FPRGD2 positive lesions were seen than [18F]NaF/[18F]FDG positive lesions. This study suggests that [18F]FPRGD2 PET/CT might be less useful for the detection of myeloma lesions in patients with advanced disease as all FLs with [18F]FPRGD2 uptake were already detected with CT alone.
journal_name
Contrast Media Mol Imagingjournal_title
Contrast media & molecular imagingauthors
Withofs N,Cousin F,De Prijck B,Bonnet C,Hustinx R,Gambhir SS,Beguin Y,Caers Jdoi
10.1155/2017/6162845subject
Has Abstractpub_date
2017-07-27 00:00:00pages
6162845eissn
1555-4309issn
1555-4317journal_volume
2017pub_type
杂志文章abstract::Generally angiogenic factors induce the expression of E-selectin in vascular endothelial cells in the tumors. In this study, we employed an anti-E-selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visualize tumor regions. The anti-E-selectin antibody was conjugated on th...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.367
更新日期:2010-03-01 00:00:00
abstract::Stem cells, cancer cells and immune cells were labeled by co-incubation with a new ultra-small iron oxide nanoparticle called Molday ION Rhodamine-B (MIRB). Iron staining, fluorescence imaging, transmission electron microscopy and flow cytometry were used to assess cell viability, function and labeling efficiency. Thi...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.456
更新日期:2011-11-01 00:00:00
abstract::Targeted magnetic resonance contrast agents (e.g. iron oxide nanoparticles) have the potential to become highly selective imaging tools. In this context, quantification of the coupled amount of protein is essential for the design of antibody- or antibody fragment-conjugated nanoparticles. Nevertheless, the presence of...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.405
更新日期:2011-05-01 00:00:00
abstract::Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1002/cmmi.442
更新日期:2011-09-01 00:00:00
abstract::Gold nanoparticles coated by gadolinium (III) chelates (Au@DTDTPA) where DTDTPA is a dithiolated bisamide derivative of diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), constituted contrast agents for both X-ray computed tomography and magnetic resonance imaging. In an MRI context, highly stable Gd(3+) compl...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1616
更新日期:2015-05-01 00:00:00
abstract::Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. These probes were based on the PLG*LWAR peptide sequence, known to be hydrolyzed between Gly and Leu by a broad panel of MMPs. A Gd-DOTA chelate was conjugated...
journal_title:Contrast media & molecular imaging
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doi:10.1002/cmmi.478
更新日期:2012-03-01 00:00:00
abstract::D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) is a Food and Drug Administration (FDA) approved biomaterial that can form nanosized micelles in aqueous solution. TPGS micelles stand as an interesting system to perform drug delivery as they can carry lipophilic drugs and overcome P glycoprotein efflux as well...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
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更新日期:2019-04-23 00:00:00
abstract::In this study we report the development of a bioconjugate between superparamagnetic iron oxide nanoparticles and Phl p5a (one of the major allergens from grass pollen). The bioconjugate also contains an optical probe (Alexa647) conjugated to the nanoparticle via biotin-streptavidin association. We show that this conju...
journal_title:Contrast media & molecular imaging
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doi:10.1002/cmmi.1466
更新日期:2012-07-01 00:00:00
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journal_title:Contrast media & molecular imaging
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doi:10.1002/cmmi.419
更新日期:2011-07-01 00:00:00
abstract:Aim:To evaluate reproducibility and stability of radiomic features as effects of the use of different volume segmentation methods and reconstruction settings. The potential of radiomics in really capturing the presence of heterogeneous tumor uptake and irregular shape was also investigated. Materials and Methods:An an...
journal_title:Contrast media & molecular imaging
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doi:10.1155/2018/5324517
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abstract:PURPOSE:Microbubble contrast agents are currently implemented in a variety of both clinical and preclinical ultrasound imaging studies. The therapeutic and diagnostic capabilities of these contrast agents are limited by their short in-vivo lifetimes, and research to lengthen their circulation times is on going. In this...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.414
更新日期:2011-05-01 00:00:00
abstract::Quantum dot micelles (pQDs) with a paramagnetic coating are promising nanoparticles for bimodal molecular imaging. Their bright fluorescence allows for optical detection, while their Gd payload enables visualization with contrast-enhanced MRI. A popular approach in molecular MRI is the targeting of abundantly expresse...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.411
更新日期:2011-03-01 00:00:00
abstract::Quantum dots (QDs) are fluorescent nanoparticles with broad excitation and narrow, wavelength-tunable emission spectra. They are used extensively for in vitro fluorescence imaging studies and more recently for in vivo small animal and pre-clinical studies. To date there has been little concern about the selection of Q...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.409
更新日期:2011-05-01 00:00:00
abstract::Carcinoma of the prostate is the most frequent diagnosed malignant tumor in men and is the second leading cause of cancer-related death in this group. The cure rate of prostate cancer is highly dependent on the stage of disease at the diagnosis and early detection is key to designing effective treatment strategies. Th...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1514
更新日期:2013-03-01 00:00:00
abstract:Background:To investigate same day 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography)/MR (Magnetic Resonance) test-retest repeatability of Standardized Uptake Value measurements normalized for body weight (SUV) and lean body mass (SUL) in different locations in the liver. Methods:This prospective study wa...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2017/8639731
更新日期:2017-05-30 00:00:00
abstract::Advances in regenerative medicine are rapidly transforming healthcare. A cornerstone of regenerative medicine is the introduction of cells that were grown or manipulated in vitro. Key questions that arise after these cells are re-introduced are: whether these cells are localized in the appropriate site; whether cells ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1002/cmmi.1547
更新日期:2013-11-01 00:00:00
abstract::We evaluated the difference in the status of dopamine transporters (DATs) depending on Parkinsonism, cerebellar, and autonomic features using F-18 FP-CIT positron emission tomography (PET) in multiple system atrophy with cerebellar ataxia (MSA-C). We also assessed whether the DAT PET could be useful in the management ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2017/8598705
更新日期:2017-11-29 00:00:00
abstract::Melanoma is the most dangerous form of skin cancer and its incidence is rising each year. Because the current methods of diagnosis based on the visual aspect of the tumor show limitations, several new techniques are emerging to help in this diagnosis, amongst which are magnetic resonance imaging (MRI) and electron par...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1554
更新日期:2014-03-01 00:00:00
abstract:Objective:The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (13C) metabolic imaging with [1-13C]-labeled pyruvate for evaluating real-time in vivo metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. Materials and Methods:3D 13C magnetic resonance sp...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2018/3215658
更新日期:2018-07-30 00:00:00
abstract::Red blood cells (RBCs) loaded with iron oxide nanoparticles have been proposed as biomimetic constructs with long half-life (ca. 20 days) in the blood compartment and potentially interesting properties (such as relaxivity) as intravascular contrast agents for magnetic resonance imaging. However, the encapsulation of n...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1562
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:Regional wall thickening measurement by delayed contrast MRI may assess myocardial viability and functional recovery of ischemic cardiomyopathy. MATERIALS AND METHODS:Delayed contrast MRI data was used in 40 patients with significant coronary artery disease and severe left ventricular dysfunction. Regional wal...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.260
更新日期:2009-01-01 00:00:00
abstract:Objective:To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods:The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently perform...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2017/1323802
更新日期:2017-04-10 00:00:00
abstract::The over-expression of sialic acid on the surface of cancer cells compared with normal ones makes this nine-carbon sugar an attractive biomarker for molecular diagnosis and therapy. Here, we describe a study on the molecular recognition of sialic acid end groups on the surface of human glioma cells by (160)Tb-DTPA-EN(...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.123
更新日期:2007-01-01 00:00:00
abstract::In vivo molecular imaging with targeted MRI contrast agents will require sensitive methods to quantify local concentrations of contrast agent, enabling not only imaging-based recognition of pathological biomarkers but also detection of changes in expression levels as a consequence of disease development, therapeutic i...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.398
更新日期:2011-01-01 00:00:00
abstract::Barium sulfate and lead oxide contrast media are frequently used for cadaver-based angiography studies. These contrast media have not previously been compared to determine which is optimal for the visualisation and measurement of blood vessels. In this study, the lower limb vessels of 16 embalmed Wistar rats, and four...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.1695
更新日期:2016-07-01 00:00:00
abstract::Glioblastoma (GBM) is the most common primary malignant type of brain neoplasm in adults and carries a dismal prognosis. The current standard of care for GBM is surgical excision followed by radiation therapy (RT) with concurrent and adjuvant temozolomide-based chemotherapy (TMZ) by six additional cycles. In addition,...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
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更新日期:2018-12-02 00:00:00
abstract::Various studies have shown that various cell types can be labeled with iron oxide particles and visualized by magnetic resonance imaging (MRI). However, reported protocols for cell labeling show a large variation in terms of labeling dose and incubation time. It is therefore not clear how different labeling protocols ...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.379
更新日期:2010-09-01 00:00:00
abstract::MRI cell tracking is a promising technique to track various cell types (stem cells, tumor cells, etc.) in living animals. Usually, cells are incubated with iron oxides (T(2) contrast agent) in order to take up the particles before being injected in vivo. Iron oxide quantification is important in such studies for valid...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1002/cmmi.497
更新日期:2012-05-01 00:00:00
abstract::Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new metho...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章
doi:10.1155/2018/7938267
更新日期:2018-11-01 00:00:00
abstract:Purpose:Several meta-analyses have reported data about the diagnostic performance of positron emission tomography or positron emission tomography/computed tomography (PET or PET/CT) with different radiotracers in patients with suspicious lung cancer (LC) or pleural tumours (PT). This review article aims at providing an...
journal_title:Contrast media & molecular imaging
pub_type: 杂志文章,评审
doi:10.1155/2020/5282698
更新日期:2020-04-25 00:00:00