Synthesis and in vitro evaluation of MR molecular imaging probes using J591 mAb-conjugated SPIONs for specific detection of prostate cancer.

Abstract:

:Carcinoma of the prostate is the most frequent diagnosed malignant tumor in men and is the second leading cause of cancer-related death in this group. The cure rate of prostate cancer is highly dependent on the stage of disease at the diagnosis and early detection is key to designing effective treatment strategies. The objective of the present study is to make a specific MR imaging probe for targeted imaging of cancer cells. We take advantage of the fact that many types of prostate cancer cells express high levels of prostate-specific membrane antigen (PSMA) on their cell surface. The imaging strategy is to use superparamagnetic iron oxide nanoparticles (SPIONs), attached to an antibody (J591) that binds to the extracellular domain of PSMA, to specifically enhance the contrast of PSMA-expressing prostate cancer cells. Conjugation of mAb J591 to commercial SPIONs was achieved using a heterobifunctional linker, sulfo-SMCC. Two types of prostate cancer cell lines were chosen for experiments: LNCaP (PSMA+) and DU145 (PSMA-). MRI and cell uptake experiments demonstrated the high potential of the synthesized nanoprobe as a specific MRI contrast agent for detection of PSMA-expressing prostate cancer cells.

authors

Abdolahi M,Shahbazi-Gahrouei D,Laurent S,Sermeus C,Firozian F,Allen BJ,Boutry S,Muller RN

doi

10.1002/cmmi.1514

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

175-84

issue

2

eissn

1555-4309

issn

1555-4317

journal_volume

8

pub_type

杂志文章
  • Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry.

    abstract::Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared 68Ga-DOTA- and 18F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods. Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-S...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2017/7645070

    authors: Virtanen H,Silvola JMU,Autio A,Li XG,Liljenbäck H,Hellberg S,Siitonen R,Ståhle M,Käkelä M,Airaksinen AJ,Helariutta K,Tolvanen T,Veres TZ,Saraste A,Knuuti J,Jalkanen S,Roivainen A

    更新日期:2017-12-31 00:00:00

  • Thermodynamic stability and kinetic inertness of a Gd-DTPA bisamide complex grafted onto gold nanoparticles.

    abstract::Gold nanoparticles coated by gadolinium (III) chelates (Au@DTDTPA) where DTDTPA is a dithiolated bisamide derivative of diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA), constituted contrast agents for both X-ray computed tomography and magnetic resonance imaging. In an MRI context, highly stable Gd(3+) compl...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.1616

    authors: Mogilireddy V,Déchamps-Olivier I,Alric C,Laurent G,Laurent S,Vander Elst L,Muller R,Bazzi R,Roux S,Tillement O,Chuburu F

    更新日期:2015-05-01 00:00:00

  • Characterization of MRI contrast agent-loaded polymeric nanocapsules as versatile vehicle for targeted imaging.

    abstract::Various contrast agents (Magnevist, Gadovist and Multihance) loaded into polymeric nanocapsules were synthesized by the inverse miniemulsion technique. The relaxivity of the resultant contrast agents was assessed at 1.5 T magnetic field strength. The ionic relaxivity of the contrast agents could at least be maintained...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.364

    authors: Sharma S,Paiphansiri U,Hombach V,Mailänder V,Zimmermann O,Landfester K,Rasche V

    更新日期:2010-03-01 00:00:00

  • Multimodal approach to assess tumour vasculature and potential treatment effect with DCE-US and DCE-MRI quantification in CWR22 prostate tumour xenografts.

    abstract::The aim of this study was to compare intratumoural heterogeneity and longitudinal changes assessed by dynamic contrast-enhanced ultrasound (DCE-US) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in prostate tumour xenografts. In vivo DCE-US and DCE-MRI were obtained 24 h pre- (day 0) and post- (day...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.1645

    authors: Arteaga-Marrero N,Rygh CB,Mainou-Gomez JF,Nylund K,Roehrich D,Heggdal J,Matulaniec P,Gilja OH,Reed RK,Svensson L,Lutay N,Olsen DR

    更新日期:2015-11-01 00:00:00

  • Contrast-Enhanced Microtomographic Characterisation of Vessels in Native Bone and Engineered Vascularised Grafts Using Ink-Gelatin Perfusion and Phosphotungstic Acid.

    abstract:Objectives:Bone ischemia and necrosis are challenging to treat, requiring investigation of native and engineered bone revascularisation processes through advanced imaging techniques. This study demonstrates an experimental two-step method for precise bone and vessel analysis in native bones or vascularised bone grafts ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2017/4035160

    authors: Sutter S,Todorov A,Ismail T,Haumer A,Fulco I,Schulz G,Scherberich A,Kaempfen A,Martin I,Schaefer DJ

    更新日期:2017-04-23 00:00:00

  • Use of 18F-FDG-PET/CT for Retroperitoneal/Intra-Abdominal Soft Tissue Sarcomas.

    abstract:Rationale:To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods:195 patients with 44 different diseases have been included. Relatio...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2018/2601281

    authors: Liu DN,Li ZW,Wang HY,Zhao M,Zhao W,Hao CY

    更新日期:2018-07-02 00:00:00

  • High-throughput screening of chemical exchange saturation transfer MR contrast agents.

    abstract::A new high-throughput MRI method for screening chemical exchange saturation transfer (CEST) agents is demonstrated, allowing simultaneous testing of multiple samples with minimal attention to sample configuration and shimming of the main magnetic field (B(0)). This approach, which is applicable to diamagnetic, paramag...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.383

    authors: Liu G,Gilad AA,Bulte JW,van Zijl PC,McMahon MT

    更新日期:2010-05-01 00:00:00

  • Magnetosomes Extracted from Magnetospirillum gryphiswaldense as Theranostic Agents in an Experimental Model of Glioblastoma.

    abstract::Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacter...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2018/2198703

    authors: Mannucci S,Tambalo S,Conti G,Ghin L,Milanese A,Carboncino A,Nicolato E,Marinozzi MR,Benati D,Bassi R,Marzola P,Sbarbati A

    更新日期:2018-07-11 00:00:00

  • In vitro setup to study permeability characteristics of contrast agents by MRI.

    abstract::An experimental setup consisting of a hollow fiber module (HFM) was developed for the in vitro study of contrast agent (CA) permeability. Controllable flow and known fiber characteristics allowed permeability studies under well-defined conditions with CAs of different molecular weight (MW). In the MRI experiments perf...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.262

    authors: Heilmann M,Vautier J,Robert P,Volk A

    更新日期:2009-03-01 00:00:00

  • Can we accurately quantify nanoparticle associated proteins when constructing high-affinity MRI molecular imaging probes?

    abstract::Targeted magnetic resonance contrast agents (e.g. iron oxide nanoparticles) have the potential to become highly selective imaging tools. In this context, quantification of the coupled amount of protein is essential for the design of antibody- or antibody fragment-conjugated nanoparticles. Nevertheless, the presence of...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.405

    authors: Rimkus G,Bremer-Streck S,Grüttner C,Kaiser WA,Hilger I

    更新日期:2011-05-01 00:00:00

  • Disruptive chemical doping in a ferritin-based iron oxide nanoparticle to decrease r2 and enhance detection with T1-weighted MRI.

    abstract::Inorganic doping was used to create flexible, paramagnetic nanoparticle contrast agents for in vivo molecular magnetic resonance imaging (MRI) with low transverse relaxivity (r2). Most nanoparticle contrast agents formed from superparamagnetic metal oxides are developed with high r2. While sensitive, they can have lim...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.1578

    authors: Clavijo Jordan MV,Beeman SC,Baldelomar EJ,Bennett KM

    更新日期:2014-09-01 00:00:00

  • Multifunctional microbubbles and nanobubbles for photoacoustic imaging.

    abstract::Photoacoustic imaging is an emerging imaging modality for noninvasive detection of tissue structural and functional anomalies. Multifunctional microbubbles (MBs) and nanobubbles (NBs) are contrast agents integrating multiple disease-targeting, imaging and therapeutic functions. Multifunctional MBs and NBs represent an...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1002/cmmi.442

    authors: Xu RX

    更新日期:2011-09-01 00:00:00

  • Dynamic contrast-enhanced computed tomography for the quantification of tumor response to vasoactive agents in a rat tumor model: preliminary results.

    abstract:RATIONALE AND OBJECTIVES:The purpose of this pilot study was to establish the ability of dynamic contrast enhanced computed tomography (DCE-CT) to detect changes in tumor blood flow (BF) and oxygenation induced by vasoactive substances in rats. MATERIALS AND METHODS:Under ultrasound guidance, a fiber-optic probe was g...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.399

    authors: Pollard RE,Larson RF

    更新日期:2011-01-01 00:00:00

  • Ability of 18F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma.

    abstract::Purpose. To investigate the value of SUV metrics and radiomic features based on the ability of 18F-FDG PET/CT in differentiating between breast lymphoma and breast carcinoma. Methods. A total of 67 breast nodules from 44 patients who underwent 18F-FDG PET/CT pretreatment were retrospectively analyzed. Radiomic paramet...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2019/4507694

    authors: Ou X,Wang J,Zhou R,Zhu S,Pang F,Zhou Y,Tian R,Ma X

    更新日期:2019-02-25 00:00:00

  • How to perform accurate and reliable measurements of longitudinal and transverse relaxation times of MRI contrast media in aqueous solutions.

    abstract::Knowledge of the longitudinal and transverse relaxation times (T(1) and T(2)) of water protons in an aqueous solution of an MRI contrast agent is essential for its characterization. These parameters can be measured at low field on low resolution spectrometers or at high field on high resolution spectrometers. The reli...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.294

    authors: Henoumont C,Laurent S,Vander Elst L

    更新日期:2009-11-01 00:00:00

  • Analytical Interference by Contrast Agents in Biochemical Assays.

    abstract:Objective:To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods:The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently perform...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2017/1323802

    authors: Otnes S,Fogh-Andersen N,Rømsing J,Thomsen HS

    更新日期:2017-04-10 00:00:00

  • Early Prediction of Treatment Response of Neuroendocrine Hepatic Metastases after Peptide Receptor Radionuclide Therapy with 90Y-DOTATOC Using Diffusion Weighted and Dynamic Contrast-Enhanced MRI.

    abstract::The purpose of this study was to determine if parameters derived from diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) can help to assess early response to peptide receptor radionuclide therapy (PRRT) with 90Y-DOTATOC in neuroendocrine hepatic metastases (NET-HM). Twenty p...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2019/1517208

    authors: Weikert T,Maas OC,Haas T,Klarhöfer M,Bremerich J,Forrer F,Sauter AW,Sommer G

    更新日期:2019-11-11 00:00:00

  • Phenylboronate 160Tb complexes for molecular recognition of glycoproteins expressed on tumor cells.

    abstract::The over-expression of sialic acid on the surface of cancer cells compared with normal ones makes this nine-carbon sugar an attractive biomarker for molecular diagnosis and therapy. Here, we describe a study on the molecular recognition of sialic acid end groups on the surface of human glioma cells by (160)Tb-DTPA-EN(...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.123

    authors: Djanashvili K,Koning GA,van der Meer AJ,Wolterbeek HT,Peters JA

    更新日期:2007-01-01 00:00:00

  • Variations in labeling protocol influence incorporation, distribution and retention of iron oxide nanoparticles into human umbilical vein endothelial cells.

    abstract::Various studies have shown that various cell types can be labeled with iron oxide particles and visualized by magnetic resonance imaging (MRI). However, reported protocols for cell labeling show a large variation in terms of labeling dose and incubation time. It is therefore not clear how different labeling protocols ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.379

    authors: van Tiel ST,Wielopolski PA,Houston GC,Krestin GP,Bernsen MR

    更新日期:2010-09-01 00:00:00

  • Connexin 43-targeted T1 contrast agent for MRI diagnosis of glioma.

    abstract::Glioblastoma multiforme is the most aggressive form of brain tumor. Early and accurate diagnosis of glioma and its borders is an important step for its successful treatment. One of the promising targets for selective visualization of glioma and its margins is connexin 43 (Cx43), which is highly expressed in reactive a...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.1653

    authors: Abakumova T,Abakumov M,Shein S,Chelushkin P,Bychkov D,Mukhin V,Yusubalieva G,Grinenko N,Kabanov A,Nukolova N,Chekhonin V

    更新日期:2016-01-01 00:00:00

  • Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging.

    abstract:Objective:The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (13C) metabolic imaging with [1-13C]-labeled pyruvate for evaluating real-time in vivo metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. Materials and Methods:3D 13C magnetic resonance sp...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2018/3215658

    authors: Autry AW,Hashizume R,James CD,Larson PEZ,Vigneron DB,Park I

    更新日期:2018-07-30 00:00:00

  • Head and Neck Cancer Tumor Segmentation Using Support Vector Machine in Dynamic Contrast-Enhanced MRI.

    abstract:Objective:We aimed to propose an automatic method based on Support Vector Machine (SVM) and Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to segment the tumor lesions of head and neck cancer (HNC). Materials and Methods:120 DCE-MRI samples were collected. Five curve features and two principal componen...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2017/8612519

    authors: Deng W,Luo L,Lin X,Fang T,Liu D,Dan G,Chen H

    更新日期:2017-09-07 00:00:00

  • Synthesis and Evaluation of 18F-Labeled Peptide for Gonadotropin-Releasing Hormone Receptor Imaging.

    abstract::The gonadotropin-releasing hormone (GnRH) receptor is overexpressed in the majority of tumors of the human reproductive system. The purpose of this study was to develop an 18F-labeled peptide for tumor GnRH receptor imaging. In this study, the GnRH (pGlu1-His2-Trp3-Ser4-Tyr5-Gly6-Leu7-Arg8-Pro9-Gly10-NH2) peptide anal...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1155/2019/5635269

    authors: Huang S,Li H,Han Y,Fu L,Ren Y,Zhang Y,Li Y,Sun P,Wang M,Wu H,Wang Q,Hu K

    更新日期:2019-03-07 00:00:00

  • VCAM-1-targeting gold nanoshell probe for photoacoustic imaging of atherosclerotic plaque in mice.

    abstract::The development of molecular probes and novel imaging modalities, allowing better resolution and specificity, is associated with an increased potential for molecular imaging of atherosclerotic plaques especially in basic and pre-clinical research applications. In that context, a photoacoustic molecular probe based on ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.1491

    authors: Rouleau L,Berti R,Ng VW,Matteau-Pelletier C,Lam T,Saboural P,Kakkar AK,Lesage F,Rhéaume E,Tardif JC

    更新日期:2013-01-01 00:00:00

  • Improved detection of pancreatic islets in vivo using double contrast.

    abstract::The transplantation of pancreatic islets containing β-cells, which produce insulin, is an alternative approach to the treatment of type 1 diabetes mellitus. The non-invasive visualization of transplanted islets can be performed using MRI; however, this requires labeling of the islets with a suitable contrast agent pri...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.432

    authors: Herynek V,Berková Z,Dovolilová E,Jirák D,Kříž J,Girman P,Saudek F,Hájek M

    更新日期:2011-07-01 00:00:00

  • USPIO-loaded red blood cells as a biomimetic MR contrast agent: a relaxometric study.

    abstract::Red blood cells (RBCs) loaded with iron oxide nanoparticles have been proposed as biomimetic constructs with long half-life (ca. 20 days) in the blood compartment and potentially interesting properties (such as relaxivity) as intravascular contrast agents for magnetic resonance imaging. However, the encapsulation of n...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.1562

    authors: Boni A,Ceratti D,Antonelli A,Sfara C,Magnani M,Manuali E,Salamida S,Gozzi A,Bifone A

    更新日期:2014-05-01 00:00:00

  • Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T(2) contrast agent with tunable proton relaxivities.

    abstract::Monodisperse mesoporous silica (mSiO(2) ) coated superparamagnetic iron oxide (Fe(3) O(4) @mSiO(2) ) nanoparticles (NPs) have been developed as a potential magnetic resonance imaging (MRI) T(2) contrast agent. To evaluate the effect of surface coating on MRI contrast efficiency, we examined the proton relaxivities of ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.1473

    authors: Ye F,Laurent S,Fornara A,Astolfi L,Qin J,Roch A,Martini A,Toprak MS,Muller RN,Muhammed M

    更新日期:2012-09-01 00:00:00

  • Considerations for the clinical use of contrast agents for cellular MRI in regenerative medicine.

    abstract::Advances in regenerative medicine are rapidly transforming healthcare. A cornerstone of regenerative medicine is the introduction of cells that were grown or manipulated in vitro. Key questions that arise after these cells are re-introduced are: whether these cells are localized in the appropriate site; whether cells ...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章,评审

    doi:10.1002/cmmi.1547

    authors: Modo M,Kolosnjaj-Tabi J,Nicholls F,Ling W,Wilhelm C,Debarge O,Gazeau F,Clement O

    更新日期:2013-11-01 00:00:00

  • Real-time 3D MRI of contrast agents in whole living mice.

    abstract::A specific mouse whole body coil and a dedicated gradient system at 4.7 T were coupled with an ultra-fast 3D gradient echo MRI and keyhole reconstruction technique to obtain 3D whole-body dynamic T(1)-weighted or T(2)*-weighted imaging. The technique was used to visualize the real-time distribution of non-targeting T(...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.429

    authors: Bled E,Hassen WB,Pourtau L,Mellet P,Lanz T,Schüler D,Voisin P,Franconi JM,Thiaudière E,Miraux S

    更新日期:2011-07-01 00:00:00

  • Optimizing quantitative in vivo fluorescence imaging with near-infrared quantum dots.

    abstract::Quantum dots (QDs) are fluorescent nanoparticles with broad excitation and narrow, wavelength-tunable emission spectra. They are used extensively for in vitro fluorescence imaging studies and more recently for in vivo small animal and pre-clinical studies. To date there has been little concern about the selection of Q...

    journal_title:Contrast media & molecular imaging

    pub_type: 杂志文章

    doi:10.1002/cmmi.409

    authors: Rosenblum LT,Kosaka N,Mitsunaga M,Choyke PL,Kobayashi H

    更新日期:2011-05-01 00:00:00